Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus

Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease

(2018) David Baglietto-Vargas et al.   AGING CELL

Prion-like seeding and nucleation of intracellular amyloid-β

(2018) Tomas T. Olsson et al.   NEUROBIOLOGY OF DISEASE

TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse

(2018) G. Aleph Prieto et al.   NEUROCHEMICAL RESEARCH

Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice

(2017) Jordano Brito-Moreira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short Aβ peptides attenuate Aβ42 toxicity in vivo

(2017) Brenda D. Moore et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony

(2017) Stefania Forner et al.   TRENDS IN NEUROSCIENCES

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

(2017) Daniela Puzzo et al.   eLife

A Novel Transgenic Rat Model with a Full Alzheimer's-Like Amyloid Pathology Displays Pre-Plaque Intracellular Amyloid-β-Associated Cognitive Impairment

(2017) Wanda Carolina Leon et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice

(2017) Tuhina Prasad et al.   Scientific Reports

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Intracellular A? and its Pathological Role in Alzheimer's Disease: Lessons from Cellular to Animal Models

(2016) Lina Ji et al.   Current Alzheimer Research

Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses

(2016) G. Aleph Prieto et al.   JOURNAL OF NEUROSCIENCE

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease

(2015) Alaina Baker-Nigh et al.   BRAIN

Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice

(2015) David Baglietto-Vargas et al.   JOURNAL OF NEUROCHEMISTRY

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus

(2015) G. Aleph Prieto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A critical analysis of the ‘amyloid cascade hypothesis’

(2014) Richard A. Armstrong   FOLIA NEUROPATHOLOGICA

Intracellular Accumulation of Amyloid-  (A ) Protein Plays a Major Role in A -Induced Alterations of Glutamatergic Synaptic Transmission and Plasticity

(2014) C. Ripoli et al.   JOURNAL OF NEUROSCIENCE

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Engineering a memory with LTD and LTP

(2014) Sadegh Nabavi et al.   NATURE

Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study

(2014) M Florencia Iulita et al.   Acta Neuropathologica Communications

Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease

(2013) Shuko Takeda et al.   FASEB JOURNAL

Intracranial Injection of Gammagard, a Human IVIg, Modulates the Inflammatory Response of the Brain and Lowers A  in APP/PS1 Mice Along a Different Time Course than Anti-A  Antibodies

(2013) T. L. Sudduth et al.   JOURNAL OF NEUROSCIENCE

Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition

(2013) David Baglietto-Vargas et al.   NEUROBIOLOGY OF DISEASE

Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment

(2013) Scott E. Counts et al.   NEUROPHARMACOLOGY

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Animal Models of Alzheimer Disease

(2013) F. M. LaFerla et al.   Cold Spring Harbor Perspectives in Medicine

Dendritic spines: from structure to in vivo function

(2012) Nathalie L Rochefort et al.   EMBO REPORTS

Intraneuronally injected amyloid beta inhibits long-term potentiation in rat hippocampal slices

(2012) Izumi Nomura et al.   JOURNAL OF NEUROPHYSIOLOGY

Sortilin is required for toxic action of Aβ oligomers (AβOs): Extracellular AβOs trigger apoptosis, and intraneuronal AβOs impair degradation pathways

(2012) Ayumi Takamura et al.   LIFE SCIENCES

Amyloid-β Protein Modulates Insulin Signaling in Presynaptic Terminals

(2012) David Heras-Sandoval et al.   NEUROCHEMICAL RESEARCH

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease

(2010) Susanne G. Mueller et al.   HUMAN BRAIN MAPPING

Activation of D1/D5 Dopamine Receptors Protects Neurons from Synapse Dysfunction Induced by Amyloid-β Oligomers

(2010) Sofia Jürgensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Actin in dendritic spines: connecting dynamics to function

(2010) Pirta Hotulainen et al.   JOURNAL OF CELL BIOLOGY

IFN-  Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid   Precursor Protein Transgenic Mice

(2010) P. Chakrabarty et al.   JOURNAL OF IMMUNOLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential dynamics and activity-dependent regulation of  - and  -neurexins at developing GABAergic synapses

(2010) Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMDA receptor-dependent signaling pathways that underlie amyloid β-protein disruption of LTP in the hippocampus

(2009) Ghiam Yamin   JOURNAL OF NEUROSCIENCE RESEARCH

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

No advantage of A 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies

(2008) C. A. Szekely et al.   NEUROLOGY

Vaccination with soluble Aβ oligomers generates toxicity-neutralizing antibodies

(2003) Mary P. Lambert et al.   JOURNAL OF NEUROCHEMISTRY