HIV-1 Vpr mediates the depletion of the cellular repressor CTIP2 to counteract viral gene silencing

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes

(2018) Luisa Robbez-Masson et al.   GENOME RESEARCH

Vpr Targets TET2 for Degradation by CRL4 VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication

(2018) Lei Lv et al.   MOLECULAR CELL

HIV-2/SIV viral protein X counteracts HUSH repressor complex

(2018) Ghina Chougui et al.   Nature Microbiology

Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex

(2018) Leonid Yurkovetskiy et al.   Nature Microbiology

Alteration of Bcl11b upon stimulation of both MAP Kinase- and Gsk3-dependent signaling pathways in double negative thymocytes

(2018) Wisam Hussein Selman et al.   Biochemistry and Cell Biology

HIV-1 Vpr Reprograms CLR4DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection

(2018) Junpeng Yan et al.   mBio

Stop HUSHing on SIV/HIV

(2018) Carine Van Lint   Nature Microbiology

Targeting the DNA-PK complex: Its rationale use in cancer and HIV-1 infection

(2018) C. Schwartz et al.   BIOCHEMICAL PHARMACOLOGY

Protein Kinase C-Mediated Phosphorylation of BCL11B at Serine 2 Negatively Regulates Its Interaction with NuRD Complexes during CD4+T-Cell Activation

(2016) Marion Dubuissez et al.   MOLECULAR AND CELLULAR BIOLOGY

HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages

(2016) Hichem Lahouassa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIC1 controls cellular- and HIV-1- gene transcription via interactions with CTIP2 and HMGA1

(2016) Valentin Le Douce et al.   Scientific Reports

Targeting the Brain Reservoirs: Toward an HIV Cure

(2016) Céline Marban et al.   Frontiers in Immunology

HIV-1 Vpr reactivates latent HIV-1 provirus by inducing depletion of class I HDACs on chromatin

(2016) Bizhan Romani et al.   Scientific Reports

HIV-1 Vpr Protein Induces Proteasomal Degradation of Chromatin-associated Class I HDACs to Overcome Latent Infection of Macrophages

(2015) Bizhan Romani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

(2015) I. A. Tchasovnikarova et al.   SCIENCE

The HIV-1 accessory protein Vpr induces the degradation of the anti-HIV-1 agent APOBEC3G through a VprBP-mediated proteasomal pathway

(2015) Dawei Zhou et al.   VIRUS RESEARCH

Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing

(2014) Nadine Laguette et al.   CELL

Vpr Overcomes Macrophage-Specific Restriction of HIV-1 Env Expression and Virion Production

(2014) Michael Mashiba et al.   Cell Host & Microbe

HMGA1 recruits CTIP2-repressed P-TEFb to the HIV-1 and cellular target promoters

(2014) Sebastian Eilebrecht et al.   NUCLEIC ACIDS RESEARCH

HIV-1 Vpr—a still “enigmatic multitasker”

(2014) Carolin A. Guenzel et al.   Frontiers in Microbiology

The Many Lives of CTIP2: From AIDS to Cancer and Cardiac Hypertrophy

(2013) Valentin Le Douce et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HIV-1 Vpr Induces the Degradation of ZIP and sZIP, Adaptors of the NuRD Chromatin Remodeling Complex, by Hijacking DCAF1/VprBP

(2013) Claire Maudet et al.   PLoS One

CTIP2 is a negative regulator of P-TEFb

(2013) T. Cherrier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection

(2013) Laurieann Casey Klockow et al.   VIROLOGY

Neutralizing antibodies inhibit HIV-1 transfer from primary dendritic cells to autologous CD4 T lymphocytes

(2012) B. Su et al.   BLOOD

Coordinated Regulation of Transcription Factor Bcl11b Activity in Thymocytes by the Mitogen-activated Protein Kinase (MAPK) Pathways and Protein Sumoylation

(2012) Ling-juan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

The HIV1 Protein Vpr Acts to Enhance Constitutive DCAF1-Dependent UNG2 Turnover

(2012) Xiaoyun Wen et al.   PLoS One

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+ T-cells

(2012) Benjamin Descours et al.   Retrovirology

Molecular Mechanisms of HIV Immune Evasion of the Innate Immune Response in Myeloid Cells

(2012) Mike Mashiba et al.   Viruses-Basel

Lentivirus Vpr and Vpx accessory proteins usurp the cullin4–DDB1 (DCAF1) E3 ubiquitin ligase

(2012) Bizhan Romani et al.   Current Opinion in Virology

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing

(2011) V. Le Douce et al.   NUCLEIC ACIDS RESEARCH

Stimulation of HIV-1 Replication in Immature Dendritic Cells in Contact with Primary CD4 T or B Lymphocytes

(2010) V. Holl et al.   JOURNAL OF VIROLOGY

HIV-1 Replication through hHR23A-Mediated Interaction of Vpr with 26S Proteasome

(2010) Ge Li et al.   PLoS One

Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a  TrCP-Dependent Mechanism

(2009) J. L. Douglas et al.   JOURNAL OF VIROLOGY

p21WAF1 gene promoter is epigenetically silenced by CTIP2 and SUV39H1

(2009) T Cherrier et al.   ONCOGENE

Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release via β-TrCP and Endo-Lysosomal Trafficking

(2009) Richard S. Mitchell et al.   PLoS Pathogens

Assembly with the Cul4A-DDB1DCAF1Ubiquitin Ligase Protects HIV-1 Vpr from Proteasomal Degradation

(2008) Erwann Le Rouzic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Vpr-Vpr Interaction in Cells monitored by two Photon Fluorescence Correlation Spectroscopy and Fluorescence Lifetime Imaging

(2008) Joelle V Fritz et al.   Retrovirology

BCL11B is a general transcriptional repressor of the HIV-1 long terminal repeat in T lymphocytes through recruitment of the NuRD complex

(2008) Valeriu B. Cismasiu et al.   VIROLOGY

HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation

(2007) Atsushi Okumura et al.   VIROLOGY