Augmentation of Glucotoxicity, Oxidative Stress, Apoptosis and Mitochondrial Dysfunction in HepG2 Cells by Palmitic Acid

Effects of Antioxidants in Reducing Accumulation of Fat in Hepatocyte

(2018) Jung-Pyo Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

(2018) Elizabeth C Hinchy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and lipotoxicity is associated with elevated adaptive antioxidant response

(2017) Jingqi Fu et al.   FOOD AND CHEMICAL TOXICOLOGY

Elucidation of Molecular Mechanisms of Streptozotocin-Induced Oxidative Stress, Apoptosis, and Mitochondrial Dysfunction in Rin-5F Pancreatic β-Cells

(2017) Arwa M. T. Al Nahdi et al.   Oxidative Medicine and Cellular Longevity

Increased Metabolic Stress in Zucker Diabetic Fatty Rat Kidney and Pancreas

(2017) Haider Raza et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Fructose and glucose combined with free fatty acids induce metabolic disorders in HepG2 cell: A new model to study the impacts of high-fructose/sucrose and high-fat diets in vitro

(2016) Liang Zhao et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Potentiation of LPS-Induced Apoptotic Cell Death in Human Hepatoma HepG2 Cells by Aspirin via ROS and Mitochondrial Dysfunction: Protection by N-Acetyl Cysteine

(2016) Haider Raza et al.   PLoS One

Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells

(2015) Karen A. Weikel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Uncoupling AMPK from autophagy: a foe that hinders the beneficial effects of metformin treatment on metabolic syndrome-associated atherosclerosis? Focus on “Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells”

(2015) Wen-Xing Ding   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Palmitate-induced impairment of glucose-stimulated insulin secretion precedes mitochondrial dysfunction in mouse pancreatic islets

(2015) J. Barlow et al.   BIOCHEMICAL JOURNAL

Palmitic acid induces autophagy in hepatocytes via JNK2 activation

(2014) Qian-qian Tu et al.   ACTA PHARMACOLOGICA SINICA

AMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response

(2014) Hongliang Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

In vitrotreatment of HepG2 cells with saturated fatty acids reproduces mitochondrial dysfunction found in nonalcoholic steatohepatitis

(2014) Inmaculada García-Ruiz et al.   Disease Models & Mechanisms

Inhibition of Autophagic Turnover in β-Cells by Fatty Acids and Glucose Leads to Apoptotic Cell Death

(2014) Shakeel U. R. Mir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Levels of Fatty Acids Contributed to Induction of Hepatic CYP3A4 Activity Induced by Diabetes — In Vitro Evidence From HepG2 Cell and Fa2N-4 Cell Lines

(2014) Nan Hu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

NAC Attenuates LPS-Induced Toxicity in Aspirin-Sensitized Mouse Macrophages via Suppression of Oxidative Stress and Mitochondrial Dysfunction

(2014) Haider Raza et al.   PLoS One

Alterations in Glutathione Redox Metabolism, Oxidative Stress, and Mitochondrial Function in the Left Ventricle of Elderly Zucker Diabetic Fatty Rat Heart

(2012) Haider Raza et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Streptozotocin-Induced Cytotoxicity, Oxidative Stress and Mitochondrial Dysfunction in Human Hepatoma HepG2 Cells

(2012) Haider Raza et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A high-fat diet decreases AMPK activity in multiple tissues in the absence of hyperglycemia or systemic inflammation in rats

(2012) Christopher R. Lindholm et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Glucose and Fatty Acid Metabolism in a 3 Tissue In-Vitro Model Challenged with Normo- and Hyperglycaemia

(2012) Elisabetta Iori et al.   PLoS One

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Lipid oversupply, selective insulin resistance, and lipotoxicity: Molecular mechanisms

(2009) Jose Antonio Chavez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

As a Matter of Fat

(2009) Rita T. Brookheart et al.   Cell Metabolism

High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and β-cell apoptosis

(2009) Zhaoyun Zhang et al.   FASEB JOURNAL

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

(2009) Seiji Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells

(2009) Sandro M. Hirabara et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

(2009) Matteo Ricchi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes

(2008) Miriam Cnop   BIOCHEMICAL SOCIETY TRANSACTIONS

Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction

(2008) Vincent Poitout et al.   ENDOCRINE REVIEWS