Cell culture media impact on drug product solution stability

Fluorescence dye-based detection of mAb aggregates in CHO culture supernatants

(2015) Albert Jesuran Paul et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control

(2015) Daniel G. Bracewell et al.   BIOTECHNOLOGY AND BIOENGINEERING

More similar than different: Host cell protein production using three null CHO cell lines

(2015) Inn H. Yuk et al.   BIOTECHNOLOGY AND BIOENGINEERING

Intrinsic fluorescence-basedat situsoft sensor for monitoring monoclonal antibody aggregation

(2015) Kaveh Ohadi et al.   BIOTECHNOLOGY PROGRESS

Trace levels of the CHO host cell protease cathepsin D caused particle formation in a monoclonal antibody product

(2015) Jared S. Bee et al.   BIOTECHNOLOGY PROGRESS

Aggregation risk prediction for antibodies and its application to biotherapeutic development

(2015) Olga Obrezanova et al.   mAbs

Characterization of Oxidative Carbonylation on Recombinant Monoclonal Antibodies

(2014) Yi Yang et al.   ANALYTICAL CHEMISTRY

Host cell protein testing by ELISAs and the use of orthogonal methods

(2014) Judith Zhu-Shimoni et al.   BIOTECHNOLOGY AND BIOENGINEERING

Control of galactosylated glycoforms distribution in cell culture system

(2014) Neil A. McCracken et al.   BIOTECHNOLOGY PROGRESS

Red colored IgG4 caused by vitamin B12 from cell culture media combined with disulfide reduction at harvest

(2014) Gayle E Derfus et al.   mAbs

Identification and characterization of host cell protein product-associated impurities in monoclonal antibody bioprocessing

(2013) Nicholas E. Levy et al.   BIOTECHNOLOGY AND BIOENGINEERING

Effect of cell culture medium components on color of formulated monoclonal antibody drug substance

(2013) Natarajan Vijayasankaran et al.   BIOTECHNOLOGY PROGRESS

Viscosity of high concentration protein formulations of monoclonal antibodies of the IgG1 and IgG4 subclass – Prediction of viscosity through protein–protein interaction measurements

(2013) Martin S. Neergaard et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Monoclonal antibody disulfide reduction during manufacturing

(2013) Katariina M. Hutterer et al.   mAbs

Protein carbonylation as a major hallmark of oxidative damage: Update of analytical strategies

(2013) Maria Fedorova et al.   MASS SPECTROMETRY REVIEWS

Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media

(2012) Jun Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Eliminating tyrosine sequence variants in CHO cell lines producing recombinant monoclonal antibodies

(2012) Lauren Feeney et al.   BIOTECHNOLOGY AND BIOENGINEERING

Quality attributes of recombinant therapeutic proteins: An assessment of impact on safety and efficacy as part of a quality by design development approach

(2012) Alex Eon-Duval et al.   BIOTECHNOLOGY PROGRESS

Characterization of the basic charge variants of a human IgG1

(2012) Timothy Kaschak et al.   mAbs

Culture temperature modulates aggregation of recombinant antibody in cho cells

(2011) Natalia Gomez et al.   BIOTECHNOLOGY AND BIOENGINEERING

Aggregates in monoclonal antibody manufacturing processes

(2011) María Vázquez-Rey et al.   BIOTECHNOLOGY AND BIOENGINEERING

Predicting solution aggregation rates for therapeutic proteins: Approaches and challenges

(2011) Christopher J. Roberts et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Developability Index: A Rapid In Silico Tool for the Screening of Antibody Aggregation Propensity

(2011) Timothy M. Lauer et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Formulation Design and High-Throughput Excipient Selection Based on Structural Integrity and Conformational Stability of Dilute and Highly Concentrated IgG1 Monoclonal Antibody Solutions

(2011) Akhilesh Bhambhani et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Protein carbonylation and metal-catalyzed protein oxidation in a cellular perspective

(2011) Ian M. Møller et al.   Journal of Proteomics

Identification of cell culture conditions to control protein aggregation of IgG fusion proteins expressed in Chinese hamster ovary cells

(2011) Ying Jing et al.   PROCESS BIOCHEMISTRY

Control of misincorporation of serine for asparagine during antibody production using CHO cells

(2010) Anurag Khetan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Protein aggregation—Pathways and influencing factors

(2010) Wei Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

mAbs

(2010) Pablo A. Scolnik   mAbs

Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development

(2010) John den Engelsman et al.   PHARMACEUTICAL RESEARCH

Increased aggregation propensity of IgG2 subclass over IgG1: Role of conformational changes and covalent character in isolated aggregates

(2010) Heather Franey et al.   PROTEIN SCIENCE

Aggregation of a monoclonal antibody induced by adsorption to stainless steel

(2009) Jared S. Bee et al.   BIOTECHNOLOGY AND BIOENGINEERING

C-terminal lysine variants in fully human monoclonal antibodies: Investigation of test methods and possible causes

(2008) Lawrence W. Dick et al.   BIOTECHNOLOGY AND BIOENGINEERING

Mechanisms of Protein Damage Induced by Cysteine Thiyl Radical Formation

(2008) Christian Schöneich   CHEMICAL RESEARCH IN TOXICOLOGY

Principles, approaches, and challenges for predicting protein aggregation rates and shelf life

(2008) William F. Weiss et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Protein aggregation: Pathways, induction factors and analysis

(2008) Hanns-Christian Mahler et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The role of copper in cysteine oxidation: study of intra- and inter-molecular reactions in mass spectrometry

(2008) Michel Prudent et al.   Metallomics

Glycosylation of Recombinant Antibody Therapeutics

(2005) Royston Jefferis   BIOTECHNOLOGY PROGRESS