Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody

Harnessing QbD, Programming Languages, and Automation for Reproducible Biology

(2016) Michael I. Sadowski et al.   TRENDS IN BIOTECHNOLOGY

Fingerprint detection and process prediction by multivariate analysis of fed-batch monoclonal antibody cell culture data

(2015) Michael Sokolov et al.   BIOTECHNOLOGY PROGRESS

Screening and assessment of performance and molecule quality attributes of industrial cell lines across different fed-batch systems

(2015) Yolande Rouiller et al.   BIOTECHNOLOGY PROGRESS

Tailoring recombinant protein quality by rational media design

(2015) David Brühlmann et al.   BIOTECHNOLOGY PROGRESS

Identification of manipulated variables for a glycosylation control strategy

(2014) Melissa M. St. Amand et al.   BIOTECHNOLOGY AND BIOENGINEERING

Modulation of mAb quality attributes using microliter scale fed-batch cultures

(2014) Yolande Rouiller et al.   BIOTECHNOLOGY PROGRESS

Cross-scale predictive modeling of CHO cell culture growth and metabolites using Raman spectroscopy and multivariate analysis

(2014) Brandon Berry et al.   BIOTECHNOLOGY PROGRESS

Data mining for rapid prediction of facility fit and debottlenecking of biomanufacturing facilities

(2014) Yang Yang et al.   JOURNAL OF BIOTECHNOLOGY

Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation

(2014) Marija Ivarsson et al.   JOURNAL OF BIOTECHNOLOGY

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

CHO cell line specific prediction and control of recombinant monoclonal antibodyN-glycosylation

(2013) Rhian K. Grainger et al.   BIOTECHNOLOGY AND BIOENGINEERING

Multivariate data analysis as a PAT tool for early bioprocess development data

(2013) Sarah M. Mercier et al.   JOURNAL OF BIOTECHNOLOGY

A high-throughput media design approach for high performance mammalian fed-batch cultures

(2013) Yolande Rouiller et al.   mAbs

Recent advances in technology supporting biopharmaceutical production from mammalian cells

(2012) M. Butler et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An Overview of Optimization Formulations for Multiresponse Surface Problems

(2012) Mostafa K. Ardakani et al.   QUALITY AND RELIABILITY ENGINEERING INTERNATIONAL

An approach to optimize correlated multiple responses using principal component analysis and desirability function

(2011) Ali Salmasnia et al.   INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY

High-throughput process development for biopharmaceutical drug substances

(2011) Rahul Bhambure et al.   TRENDS IN BIOTECHNOLOGY

Multivariate data analysis on historical IPV production data for better process understanding and future improvements

(2010) Yvonne E. Thomassen et al.   BIOTECHNOLOGY AND BIOENGINEERING

Improved process analytical technology for protein a chromatography using predictive principal component analysis tools

(2010) Ying Hou et al.   BIOTECHNOLOGY AND BIOENGINEERING

Applied advanced process analytics in biopharmaceutical manufacturing: Challenges and prospects in real-time monitoring and control

(2010) Cenk Ündey et al.   JOURNAL OF PROCESS CONTROL

Quality by design case study: An integrated multivariate approach to drug product and process development

(2009) Jun Huang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cross-validation of component models: A critical look at current methods

(2008) R. Bro et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

In situ 2D fluorometry and chemometric monitoring of mammalian cell cultures

(2008) Ana P. Teixeira et al.   BIOTECHNOLOGY AND BIOENGINEERING

Pattern matching in batch bioprocesses—Comparisons across multiple products and operating conditions

(2008) J.C. Gunther et al.   COMPUTERS & CHEMICAL ENGINEERING