The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation

Role of Myeloid-Epithelial-Reproductive Tyrosine Kinase and Macrophage Polarization in the Progression of Atherosclerotic Lesions Associated With Nonalcoholic Fatty Liver Disease

(2019) Mirella Pastore et al.   Frontiers in Pharmacology

Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency

(2017) Marcia A. Munoz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Different Regulation of Interleukin-1 Production and Activity in Monocytes and Macrophages: Innate Memory as an Endogenous Mechanism of IL-1 Inhibition

(2017) Mariusz P. Madej et al.   Frontiers in Pharmacology

Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation

(2016) Rafaela F. da Silva et al.   ATHEROSCLEROSIS

Statin modulation of monocyte phenotype and function: implications for HIV-1-associated neurocognitive disorders

(2016) Anjana Yadav et al.   JOURNAL OF NEUROVIROLOGY

Periodic fevers and autoinflammatory syndromes in childhood

(2016) Genevieve T Ostring et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Control of the innate immune response by the mevalonate pathway

(2016) Murali K Akula et al.   NATURE IMMUNOLOGY

Protein prenylation: unique fats make their mark on biology

(2016) Mei Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immune Cell Phenotype and Function in Sepsis

(2016) Thomas Rimmelé et al.   SHOCK

The rapid lipopolysaccharide-induced release of matrix metalloproteinases 9 is suppressed by simvastatin

(2015) Dan-Dong Li et al.   CELL BIOLOGY INTERNATIONAL

Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link

(2015) Paola Tricarico et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interleukin-1 potently contributes to 25-hydroxycholesterol-induced synergistic cytokine production in smooth muscle cell-monocyte interactions

(2014) Hang Fu et al.   ATHEROSCLEROSIS

Pleiotropic Effects of Statins in Atherosclerotic Disease: Focus on the Antioxidant Activity of Atorvastatin

(2014) Elisabetta Profumo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Dehydroxymethylepoxyquinomicin, a novel nuclear factor–κB inhibitor, reduces chemokines and adhesion molecule expression induced by IL-1β in human corneal fibroblasts

(2014) Sosuke Inokawa et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Unprenylated RhoA Contributes to IL-1β Hypersecretion in Mevalonate Kinase Deficiency Model through Stimulation of Rac1 Activity

(2014) Robert van der Burgh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory stress reduces the effectiveness of statins in the kidney by disrupting HMGCoA reductase feedback regulation

(2014) Y. Chen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Immunological aspects of atherosclerosis: Figure 1

(2013) Kevin J. Woollard   CLINICAL SCIENCE

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Distribution of macrophage polarization markers in human atherosclerosis

(2012) J. Lauran Stöger et al.   ATHEROSCLEROSIS

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers

(2011) E. Sierra-Filardi et al.   BLOOD

CX3CR1 defines functionally distinct intestinal mononuclear phagocyte subsets which maintain their respective functions during homeostatic and inflammatory conditions

(2011) Benjamin Weber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures

(2010) Harald Loppnow et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production

(2009) Li Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inflammation in Atherosclerosis

(2009) Peter Libby et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

HMG-CoA reductase inhibition induces IL-1  release through Rac1/PI3K/PKB-dependent caspase-1 activation

(2008) L. M. Kuijk et al.   BLOOD

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Invited review: Vascular cells contribute to atherosclerosis by cytokine- and innate-immunity-related inflammatory mechanisms

(2008) Harald Loppnow et al.   Innate Immunity

Statin synergizes with LPS to induce IL-1β release by THP-1 cells through activation of caspase-1

(2008) Loes M. Kuijk et al.   MOLECULAR IMMUNOLOGY