A split-GFP tool reveals differences in the sub-mitochondrial distribution of wt and mutant alpha-synuclein

Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment

(2018) Jimena H. Martínez et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Tau localises within mitochondrial sub-compartments and its caspase cleavage affects ER-mitochondria interactions and cellular Ca 2+ handling

(2018) Domenico Cieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

Asiatic Acid Prevents Oxidative Stress and Apoptosis by Inhibiting the Translocation of α-Synuclein Into Mitochondria

(2018) Hongqun Ding et al.   Frontiers in Neuroscience

Pα-syn* mitotoxicity is linked to MAPK activation and involves tau phosphorylation and aggregation at the mitochondria

(2018) Diego Grassi et al.   NEUROBIOLOGY OF DISEASE

Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology

(2017) Inês S. Amorim et al.   JOURNAL OF CELL SCIENCE

Mechanism of α-synuclein translocation through a VDAC nanopore revealed by energy landscape modeling of escape time distributions

(2017) David P. Hoogerheide et al.   Nanoscale

Cytosolic proteostasis through importing of misfolded proteins into mitochondria

(2017) Linhao Ruan et al.   NATURE

αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease

(2017) Victorio Martin Pozo Devoto et al.   Scientific Reports

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase

(2016) M. H. R. Ludtmann et al.   JOURNAL OF NEUROSCIENCE

Structural basis of synaptic vesicle assembly promoted by α-synuclein

(2016) Giuliana Fusco et al.   Nature Communications

α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease

(2015) Tatiana K. Rostovtseva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication

(2015) Cristina Guardia-Laguarta et al.   MOVEMENT DISORDERS

Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons

(2015) A K Reeve et al.   Cell Death & Disease

Analysis of the Catecholaminergic Phenotype in Human SH-SY5Y and BE(2)-M17 Neuroblastoma Cell Lines upon Differentiation

(2015) Roberta Filograna et al.   PLoS One

A new split-GFP-based probe reveals DJ-1 translocation into the mitochondrial matrix to sustain ATP synthesis upon nutrient deprivation

(2014) Tito Calì et al.   HUMAN MOLECULAR GENETICS

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging

(2014) Victoria Hung et al.   MOLECULAR CELL

Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein

(2014) Sudhakar Raja Subramaniam et al.   NEUROBIOLOGY OF DISEASE

The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle

(2013) Kai-Li Ma et al.   NEUROPHARMACOLOGY

α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions

(2012) Tito Calì et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis

(2010) Olivier Gavet et al.   DEVELOPMENTAL CELL

The Transgenic Overexpression of α-Synuclein and Not Its Related Pathology Associates with Complex I Inhibition

(2010) Virginie Loeb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

(2010) Shankar J. Chinta et al.   NEUROSCIENCE LETTERS

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases

(2009) Latha Devi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The genetics of Parkinson's syndromes: a critical review

(2009) John Hardy et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Nuclear and neuritic distribution of serine-129 phosphorylated α-synuclein in transgenic mice

(2009) H. Schell et al.   NEUROSCIENCE

α-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity

(2009) Guangwei Liu et al.   NEUROSCIENCE LETTERS

LACTB is a filament-forming protein localized in mitochondria

(2009) Zydrune Polianskyte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Semi-quantitative analysis of α-synuclein in subcellular pools of rat brain neurons: An immunogold electron microscopic study using a C-terminal specific monoclonal antibody

(2008) Ling Zhang et al.   BRAIN RESEARCH

Mitochondrial association of alpha-synuclein causes oxidative stress

(2008) M. S. Parihar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial translocation of α-synuclein is promoted by intracellular acidification

(2008) Nelson B. Cole et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells

(2008) Shaik Shavali et al.   NEUROSCIENCE LETTERS