Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy
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Title
Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy
Authors
Keywords
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Journal
Cell Death & Disease
Volume 10, Issue 11, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-10-17
DOI
10.1038/s41419-019-2033-z
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Note: Only part of the references are listed.- Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway
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- (2018) Tatsunori Nishimura et al. ONCOGENE
- MYCN induces neuroblastoma in primary neural crest cells
- (2017) R R Olsen et al. ONCOGENE
- A New View into the Regulation of Purine Metabolism: The Purinosome
- (2017) Anthony M. Pedley et al. TRENDS IN BIOCHEMICAL SCIENCES
- The MYCN Protein in Health and Disease
- (2017) María Victoria Ruiz-Pérez et al. Genes
- Parsing Myc Paralogs in Oncogenesis
- (2016) Haritha Mathsyaraja et al. CANCER CELL
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway
- (2016) Gregory S. Ducker et al. Cell Metabolism
- Recent Trends in Nucleotide Synthesis
- (2016) Béatrice Roy et al. CHEMICAL REVIEWS
- Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis
- (2016) Daniel R. Carter et al. Molecular Oncology
- Spatial colocalization and functional link of purinosomes with mitochondria
- (2016) J. B. French et al. SCIENCE
- Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells
- (2016) Mengling Liu et al. Cell Reports
- Fundamentals of cancer metabolism
- (2016) R. J. DeBerardinis et al. Science Advances
- TWIST1 is a direct transcriptional target of MYCN and MYC in neuroblastoma
- (2015) Abdelkader Selmi et al. CANCER LETTERS
- MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells
- (2015) Brian J. Altman et al. Cell Metabolism
- Neuroblastoma
- (2015) Meredith S. Irwin et al. PEDIATRIC CLINICS OF NORTH AMERICA
- ATF4 and N-Myc coordinate glutamine metabolism inMYCN-amplified neuroblastoma cells through ASCT2 activation
- (2014) Ping Ren et al. JOURNAL OF PATHOLOGY
- The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic Potential
- (2014) Himisha Beltran MOLECULAR CANCER RESEARCH
- Mechanisms of neuroblastoma regression
- (2014) Garrett M. Brodeur et al. Nature Reviews Clinical Oncology
- Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer
- (2014) Roland Nilsson et al. Nature Communications
- Optimization of harvesting, extraction, and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells
- (2013) Huichang Bi et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans
- (2013) Hong Zhao et al. CHEMICAL COMMUNICATIONS
- Metabolic targets for cancer therapy
- (2013) Lorenzo Galluzzi et al. NATURE REVIEWS DRUG DISCOVERY
- MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells
- (2013) H. Zirath et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anisomycin induces glioma cell death via down-regulation of PP2A catalytic subunit in vitro
- (2012) Jun-yang Li et al. ACTA PHARMACOLOGICA SINICA
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
- (2012) Guangchuang Yu et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- Cancer Cell Metabolism: One Hallmark, Many Faces
- (2012) Jason R. Cantor et al. Cancer Discovery
- Biological and clinical heterogeneity of MYCN-amplified medulloblastoma
- (2011) Andrey Korshunov et al. ACTA NEUROPATHOLOGICA
- Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism
- (2010) Anne S. Tibbetts et al. Annual Review of Nutrition
- Combinatorial Regulation of Neuroblastoma Tumor Progression by N-Myc and Hypoxia Inducible Factor HIF-1
- (2010) G. Qing et al. CANCER RESEARCH
- Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
- (2010) T.-C. Chou CANCER RESEARCH
- Recent Advances in Neuroblastoma
- (2010) John M. Maris NEW ENGLAND JOURNAL OF MEDICINE
- The N-Myc-DLL3 Cascade Is Suppressed by the Ubiquitin Ligase Huwe1 to Inhibit Proliferation and Promote Neurogenesis in the Developing Brain
- (2009) Xudong Zhao et al. DEVELOPMENTAL CELL
- One-Carbon Metabolism–Genome Interactions in Folate-Associated Pathologies
- (2009) Patrick J. Stover JOURNAL OF NUTRITION
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report
- (2008) Susan L. Cohn et al. JOURNAL OF CLINICAL ONCOLOGY
- Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells
- (2008) S. An et al. SCIENCE
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