The Tripeptide RER Mimics Secreted Amyloid Precursor Protein-Alpha in Upregulating LTP

Glutamate receptor trafficking and protein synthesis mediate the facilitation of ltp by secreted amyloid precursor protein-alpha

(2019) Bruce G. Mockett et al.   JOURNAL OF NEUROSCIENCE

A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease

(2019) Jodi A. Morrissey et al.   NEUROPHARMACOLOGY

Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition

(2018) Max C Richter et al.   EMBO JOURNAL

Alzheimer's disease research: the future of BACE inhibitors

(2018) Talha Burki   LANCET

Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease

(2018) Valerie T. Y. Tan et al.   Molecular Brain

Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα

(2017) Bruce G. Mockett et al.   Frontiers in Molecular Neuroscience

Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer’s Disease: Comparison and Contrast with Microtubule-Associated Protein Tau

(2016) Kenneth Hensley et al.   JOURNAL OF ALZHEIMERS DISEASE

Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease

(2016) Ahsan Habib et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model

(2015) Romain Fol et al.   ACTA NEUROPATHOLOGICA

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

(2014) Meike Hick et al.   ACTA NEUROPATHOLOGICA

The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease

(2014) David A. Drachman   Alzheimers & Dementia

Regulation of Presynaptic Ca2+, Synaptic Plasticity and Contextual Fear Conditioning by a N-terminal  -Amyloid Fragment

(2014) J. L. M. Lawrence et al.   JOURNAL OF NEUROSCIENCE

Synaptic changes in Alzheimer’s disease and its models

(2012) J. Pozueta et al.   NEUROSCIENCE

The memory enhancing effect of the APP-derived tripeptide Ac-rER is mediated through CRMP2

(2011) Radmila Mileusnic et al.   JOURNAL OF NEUROCHEMISTRY

Proteolytic processing of Alzheimer’s β-amyloid precursor protein

(2011) Han Zhang et al.   JOURNAL OF NEUROCHEMISTRY

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Beta-amyloid protein (25-35) disrupts hippocampal network activity: Role of FYN-kinase

(2009) Fernando Peña et al.   HIPPOCAMPUS

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Secreted amyloid precursor protein-α upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism

(2009) Ana M. Claasen et al.   NEUROSCIENCE LETTERS

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE