Resolution of allergic asthma

Relationship Between Benralizumab Exposure and Efficacy for Patients with Severe Eosinophilic Asthma

(2019) Yen Lin Chia et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

What Are Those Neutrophils Doing in Severe Asthma Anyway?

(2019) William W. Busse   Journal of Allergy and Clinical Immunology-In Practice

Impact of Omalizumab on Food Allergy in Patients Treated for Asthma: A Real-Life Study

(2019) Alessandro Fiocchi et al.   Journal of Allergy and Clinical Immunology-In Practice

A Statewide Study of the Epidemiology of Emergency Medical Servicesʼ Management of Pediatric Asthma

(2019) Jennifer N. Fishe et al.   PEDIATRIC EMERGENCY CARE

α-Galactosylceramide treatment before allergen sensitization promotes iNKT cell-mediated induction of Treg cells, preventing Th2 cell responses in murine asthma

(2019) Qianhui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered mast cell activity in response to rhinovirus infection provides novel insight into asthma

(2019) Haiwen Liu et al.   JOURNAL OF ASTHMA

Mepolizumab in adolescents with severe eosinophilic asthma not eligible for omalizumab: one center’s early clinical experience

(2019) Elise Weir et al.   JOURNAL OF ASTHMA

Prophylactic allergen immunotherapy with Der p 2 prevents murine asthma by regulating lung GM-CSF

(2019) Eline Haspeslagh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Short- and long-term real-world effectiveness of omalizumab in severe allergic asthma: systematic review of 42 studies published 2008-2018

(2019) Karen M. MacDonald et al.   Expert Review of Clinical Immunology

Circulating mast cell progenitors correlate with reduced lung function in allergic asthma

(2019) M Salomonsson et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Goblet cell hyperplasia as a feature of neutrophilic asthma

(2019) Khuder Alagha et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Rapid Onset of Effect of Benralizumab on Morning Peak Expiratory Flow in Severe, Uncontrolled Asthma

(2019) Geoffrey Chupp et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Myeloid‐derived suppressor cells: roles and relations with Th2, Th17 and Treg cells in asthma

(2019) Qingdong Guan et al.   ALLERGY

Neutrophilic inflammation in asthma and defective epithelial translational control

(2019) Abilash Ravi et al.   EUROPEAN RESPIRATORY JOURNAL

The Cytokines of Asthma

(2019) Bart N. Lambrecht et al.   IMMUNITY

Benralizumab: A New Approach for the Treatment of Severe Eosinophilic Asthma

(2019) I Dávila González et al.   JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY

Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3–stimulated murine basophils

(2019) Soichiro Yoshikawa et al.   Science Signaling

The significance of CD163-expressing macrophages in asthma

(2019) Yoshihisa Tokunaga et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Epidemiology of Asthma in Children and Adults

(2019) Shyamali C. Dharmage et al.   Frontiers in Pediatrics

Meeting the Challenge of Identifying New Treatments for Type 2-low Neutrophilic Asthma

(2019) Or Kalchiem-Dekel et al.   CHEST

Elevated serum IgE, OCS-dependence and IL-17/22 expression in highly neutrophilic asthma

(2019) Michela Bullone et al.   EUROPEAN RESPIRATORY JOURNAL

A T cell–myeloid IL-10 axis regulates pathogenic IFN-γ–dependent immunity in a mouse model of type 2–low asthma

(2019) William J. Branchett et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of IL-17 in asthma pathogenesis and its implications for the clinic

(2019) Rakhee K Ramakrishnan et al.   Expert Review of Respiratory Medicine

Increased Ratio of Matrix Metalloproteinase-9 (MMP-9)/Tissue Inhibitor Metalloproteinase-1 from Alveolar Macrophages in Chronic Asthma with a Fast Decline in FEV1 at 5-Year Follow-up

(2019) Fu-Tsai Chung et al.   Journal of Clinical Medicine

Locally instructed CXCR4hi neutrophils trigger environment-driven allergic asthma through the release of neutrophil extracellular traps

(2019) Coraline Radermecker et al.   NATURE IMMUNOLOGY

Liberty Asthma QUEST: Phase 3 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate Dupilumab Efficacy/Safety in Patients with Uncontrolled, Moderate-to-Severe Asthma

(2018) William W. Busse et al.   ADVANCES IN THERAPY

Role of neutrophils in allergic asthma

(2018) Coraline Radermecker et al.   CURRENT OPINION IN IMMUNOLOGY

Of pleiotropy and trajectories: Does the TGF-β pathway link childhood asthma and chronic obstructive pulmonary disease?

(2018) Avery DeVries et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy and safety of dupilumab in perennial allergic rhinitis and comorbid asthma

(2018) Steven F. Weinstein et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

(2018) Klaus F. Rabe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

(2018) Mario Castro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Contribution of repeated infections in asthma persistence from preschool to school age: Design and characteristics of the PreDicta cohort

(2018) Paraskevi Xepapadaki et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Reslizumab for Treating Asthma with Elevated Blood Eosinophils Inadequately Controlled by Inhaled Corticosteroids: An Evidence Review Group Perspective of a NICE Single Technology Appraisal

(2018) Keith Cooper et al.   PHARMACOECONOMICS

Tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils): a systematic review and meta-analysis

(2018) Helen L Petsky et al.   THORAX

Macrophage polarization and allergic asthma

(2018) Arjun Saradna et al.   Translational Research

Omalizumab Effectiveness by Biomarker Status in Patients with Asthma: Evidence From PROSPERO, A Prospective Real-World Study

(2018) Thomas B. Casale et al.   Journal of Allergy and Clinical Immunology-In Practice

Rhinovirus Species-Specific Antibodies Differentially Reflect Clinical Outcomes in Health and Asthma

(2018) Spyridon Megremis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Dupilumab improves symptoms, quality of life, and productivity in uncontrolled persistent asthma

(2018) Jonathan Corren et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization

(2018) Milena Paw et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blimp-1, a negative regulator of Th9 development, orchestrates the resolution of airway inflammation in allergic asthma

(2018) Susetta Finotto   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α

(2018) Li Xu et al.   Journal of Inflammation-London

Bcl11b Regulates IL-17 Through the TGF-β/Smad Pathway in HDM-Induced Asthma

(2018) Si Chen et al.   Allergy Asthma & Immunology Research

Th17/Treg homeostasis, but not Th1/Th2 homeostasis, is implicated in exacerbation of human bronchial asthma

(2018) Xiao-ling Zou et al.   Therapeutics and Clinical Risk Management

Children with Neutrophil-Predominant Severe Asthma Have Proinflammatory Neutrophils With Enhanced Survival and Impaired Clearance

(2018) Jocelyn R. Grunwell et al.   Journal of Allergy and Clinical Immunology-In Practice

Omalizumab discontinuation in children with severe allergic asthma: an observational real life study

(2018) A Deschildre et al.   ALLERGY

Oxidative stress and macrophages: driving forces behind exacerbations of asthma and COPD?

(2018) Linsey Elisabeth Susan de Groot et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mast Cell-Mediated Orchestration of the Immune Responses in Human Allergic Asthma: Current Insights

(2018) Daniel Elieh Ali Komi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

New insights into the function, development, and plasticity of type 2 innate lymphoid cells

(2018) Lisette Krabbendam et al.   IMMUNOLOGICAL REVIEWS

Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries

(2018) Brooks W. Morgan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Preventative tracheal administration of interleukin-27 attenuates allergic asthma by improving the lung Th1 microenvironment

(2018) Xiaojing Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of Th17-cell related cytokines in geriatric asthma

(2018) Zhang Quan-san et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

(2018) William W Busse et al.   Lancet Respiratory Medicine

Rhinovirus species/genotypes and interferon-λ: subtypes, receptor and polymorphisms – missing pieces of the puzzle of childhood asthma?

(2017) Annika Bergauer et al.   EUROPEAN RESPIRATORY JOURNAL

Role of TGF-β in anti-rhinovirus immune responses in asthmatic patients

(2017) Carina Bielor et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence

(2017) Frederick J. Rubner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allergen immunotherapy for allergic asthma: a systematic overview of systematic reviews

(2017) Felix Asamoah et al.   Clinical and Translational Allergy

A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13)

(2017) Trevor T. Hansel et al.   EBioMedicine

Critical roles of adenosine A2A receptor in regulating the balance of Treg/Th17 cells in allergic asthma

(2016) Linlin Wang et al.   Clinical Respiratory Journal

The IL-17-Th1/Th17 pathway: an attractive target for lung cancer therapy?

(2016) Markus Joerger et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Lung-resident eosinophils represent a distinct regulatory eosinophil subset

(2016) Claire Mesnil et al.   JOURNAL OF CLINICAL INVESTIGATION

Th9 cells in immunity and immunopathological diseases

(2016) Markus F. Neurath et al.   Seminars in Immunopathology

Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity

(2015) Joanne E. Sordillo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Peripheral blood Th9 cells and eosinophil apoptosis in asthma patients

(2015) Deimantė Hoppenot et al.   Medicina-Lithuania

Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme

(2015) Norbert Krug et al.   NEW ENGLAND JOURNAL OF MEDICINE

The changing face of asthma and its relation with microbes

(2015) Chris S. Earl et al.   TRENDS IN MICROBIOLOGY

p-STAT6, PU.1, and NF-κB are involved in allergen-induced late-phase airway inflammation in asthma patients

(2015) Deimante Hoppenot et al.   BMC Pulmonary Medicine

Peripheral blood Th9 cells and eosinophil apoptosis in asthma patients

(2015) Deimantė Hoppenot et al.   Medicina-Lithuania

IL-10 and Regulatory T Cells Cooperate in Allergen-Specific Immunotherapy To Ameliorate Allergic Asthma

(2014) Livia Böhm et al.   JOURNAL OF IMMUNOLOGY

Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression

(2014) Wei Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Tyk-2 in Th9 and Th17 cells in allergic asthma

(2014) Caroline Übel et al.   Scientific Reports

Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection

(2013) Paula Licona-Limón et al.   IMMUNITY

Th9 cells: differentiation and disease

(2013) Mark H. Kaplan   IMMUNOLOGICAL REVIEWS

The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF-like (BATF), regulates lymphocyte- and mast cell–driven immune responses in the setting of allergic asthma

(2013) Caroline Übel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Th9 cell development requires a BATF-regulated transcriptional network

(2013) Rukhsana Jabeen et al.   JOURNAL OF CLINICAL INVESTIGATION

A randomized, controlled trial to evaluate the effect of an anti-interleukin-9 monoclonal antibody in adults with uncontrolled asthma

(2013) Chad K Oh et al.   RESPIRATORY RESEARCH

Rhinovirus-induced interferon production is not deficient in well controlled asthma

(2013) Annemarie Sykes et al.   THORAX

The symphony of the ninth: the development and function of Th9 cells

(2012) Rukhsana Jabeen et al.   CURRENT OPINION IN IMMUNOLOGY

The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses

(2012) Jinfang Zhu et al.   IMMUNITY

Innate and adaptive immune responses in asthma

(2012) Stephen T Holgate   NATURE MEDICINE

A role for T-bet-mediated tumour immune surveillance in anti-IL-17A treatment of lung cancer

(2011) S. Reppert et al.   Nature Communications

CD4+ Regulatory T Cells Control TH17 Responses in a Stat3-Dependent Manner

(2009) A. Chaudhry et al.   SCIENCE