Selective activation of TWIK-related acid-sensitive K+ 3 subunit–containing channels is analgesic in rodent models

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

(2019) Marcus Schewe et al.   SCIENCE

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK

(2018) Perrine Royal et al.   NEURON

Advances in Achieving Opioid Analgesia Without Side Effects

(2018) Halina Machelska et al.   Frontiers in Pharmacology

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a

(2017) Jennifer R. Deuis et al.   Scientific Reports

Modeling protein quaternary structure of homo- and hetero-oligomers beyond binary interactions by homology

(2017) Martino Bertoni et al.   Scientific Reports

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief

(2016) Edward C Emery et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Potassium channels in neuropathic pain

(2016) Jérôme Busserolles et al.   PAIN

TASK-1 and TASK-3 may form heterodimers in human atrial cardiomyocytes

(2015) Susanne Rinné et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

(2015) Y. Y. Dong et al.   SCIENCE

Studying ongoing and spontaneous pain in rodents - challenges and opportunities

(2014) Anke Tappe-Theodor et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Variations in Potassium Channel Genes Are Associated With Breast Pain in Women Prior to Breast Cancer Surgery

(2014) Dale J. Langford et al.   JOURNAL OF NEUROGENETICS

Regulating excitability of peripheral afferents: emerging ion channel targets

(2014) Stephen G Waxman et al.   NATURE NEUROSCIENCE

Reward and motivation in pain and pain relief

(2014) Edita Navratilova et al.   NATURE NEUROSCIENCE

Peripheral thermosensation in mammals

(2014) Joris Vriens et al.   NATURE REVIEWS NEUROSCIENCE

Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels

(2014) Marco Lolicato et al.   NEURON

Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain

(2014) Alistair Mathie et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ion Channel Profile of TRPM8 Cold Receptors Reveals a Role of TASK-3 Potassium Channels in Thermosensation

(2014) Cruz Morenilla-Palao et al.   Cell Reports

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

An Extracellular Ion Pathway Plays a Central Role in the Cooperative Gating of a K2PK+Channel by Extracellular pH

(2013) Wendy González et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 channels in mouse carotid body type-1 cells

(2013) Philip J. Turner et al.   JOURNAL OF PHYSIOLOGY-LONDON

Expression of background potassium channels in rat DRG is cell-specific and down-regulated in a neuropathic pain model

(2013) Sarah L. Pollema-Mays et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Crystal Structure of the Human Two-Pore Domain Potassium Channel K2P1

(2012) A. N. Miller et al.   SCIENCE

The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons

(2011) Lishi Li et al.   CELL

Discovery of a Pharmacologically Active Antagonist of the Two-Pore-Domain Potassium Channel K2P9.1 (TASK-3)

(2011) Craig A. Coburn et al.   ChemMedChem

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Amygdala circuitry mediating reversible and bidirectional control of anxiety

(2011) Kay M. Tye et al.   NATURE

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Fpocket: An open source platform for ligand pocket detection

(2009) Vincent Le Guilloux et al.   BMC BIOINFORMATICS

Heteromeric TASK-1/TASK-3 is the major oxygen-sensitive background K+channel in rat carotid body glomus cells

(2009) Donghee Kim et al.   JOURNAL OF PHYSIOLOGY-LONDON

RosettaLigand Docking with Full Ligand and Receptor Flexibility

(2008) Ian W. Davis et al.   JOURNAL OF MOLECULAR BIOLOGY