Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14

Hepatic conditional knockout of ATF6 exacerbates liver metabolic damage by repressing autophage through MTOR pathway

(2018) Xiaofang Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Unfolded Protein Response Sensors in Hepatic Lipid Metabolism and Nonalcoholic Fatty Liver Disease

(2018) Anne Henkel   SEMINARS IN LIVER DISEASE

Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN

(2018) Bin Liu et al.   Nature Communications

Endoplasmic Reticulum Stress Inducer Tunicamycin Alters Hepatic Energy Homeostasis in Mice

(2017) Bin Feng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

USP14 inhibitor attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice

(2017) Jia-Wei Min et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of hepatic glucose metabolism in health and disease

(2017) Max C. Petersen et al.   Nature Reviews Endocrinology

Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

(2017) Jia Cao et al.   Nature Communications

Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction

(2016) Junli Liu et al.   CELL

Increased lipogenesis in spite of upregulated hepatic 5'AMP-activated protein kinase in human non-alcoholic fatty liver

(2016) Christian von Loeffelholz et al.   HEPATOLOGY RESEARCH

Targeting hepatic glucose metabolism in the treatment of type 2 diabetes

(2016) Amy K. Rines et al.   NATURE REVIEWS DRUG DISCOVERY

NAFLD and diabetes mellitus

(2016) Herbert Tilg et al.   Nature Reviews Gastroenterology & Hepatology

The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics

(2016) Mingjing He et al.   Cell and Bioscience

Metabolic roles of PGC-1α and its implications for type 2 diabetes

(2015) A. Besseiche et al.   DIABETES & METABOLISM

MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4

(2015) Kai Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1 

(2014) A. Hyrskyluoto et al.   HUMAN MOLECULAR GENETICS

Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s–PPARα axis signalling

(2014) Mengle Shao et al.   Nature Communications

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Central Activating Transcription Factor 4 (ATF4) Regulates Hepatic Insulin Resistance in Mice via S6K1 Signaling and the Vagus Nerve

(2013) Q. Zhang et al.   DIABETES

A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number

(2013) Brandon J. Walters et al.   JOURNAL OF PHYSIOLOGY-LONDON

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

Selective Insulin and Leptin Resistance in Metabolic Disorders

(2012) A. Christine Könner et al.   Cell Metabolism

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

Transcriptional Co-activator p300 Maintains Basal Hepatic Gluconeogenesis

(2012) Ling He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism

(2012) Yingfeng Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

NF-κB–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action

(2012) Liang Sheng et al.   NATURE MEDICINE

New insights into ER stress-induced insulin resistance

(2012) Mélissa Flamment et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice

(2011) Cheng Ji et al.   HEPATOLOGY

Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice

(2011) Michael J. Jurczak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction

(2011) Yingjiang Zhou et al.   NATURE MEDICINE

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PKA phosphorylation couples hepatic inositol-requiring enzyme 1  to glucagon signaling in glucose metabolism

(2011) T. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum stress, obesity and diabetes

(2011) Miriam Cnop et al.   TRENDS IN MOLECULAR MEDICINE

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice

(2010) Julien Bricambert et al.   JOURNAL OF CLINICAL INVESTIGATION

The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation

(2010) Sang Won Park et al.   NATURE MEDICINE

USP14 inhibits ER-associated degradation via interaction with IRE1α

(2009) Atsushi Nagai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nutrient-dependent regulation of PGC-1α's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5

(2009) John E. Dominy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein

(2009) Ling He et al.   CELL

The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis

(2009) Yiguo Wang et al.   NATURE

Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss

(2008) M. F. Gregor et al.   DIABETES

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY