T cell receptor repertoire usage in cancer as a surrogate marker for immune responses

Clonotypic Diversification of Intratumoral T Cells Following Sipuleucel-T Treatment in Prostate Cancer Subjects

(2016) Nadeem Sheikh et al.   CANCER RESEARCH

Inherent and Tumor-Driven Immune Tolerance in the Prostate Microenvironment Impairs Natural Killer Cell Antitumor Activity

(2016) Christine Pasero et al.   CANCER RESEARCH

Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution

(2016) Line Pedersen et al.   Cell Metabolism

The Length Distribution of Class I–Restricted T Cell Epitopes Is Determined by Both Peptide Supply and MHC Allele–Specific Binding Preference

(2016) Thomas Trolle et al.   JOURNAL OF IMMUNOLOGY

Next-generation TCR sequencing - a tool to understand T-cell infiltration in human cancers

(2016) Isabel Poschke et al.   JOURNAL OF PATHOLOGY

T cell receptor β-chain repertoire analysis reveals intratumour heterogeneity of tumour-infiltrating lymphocytes in oesophageal squamous cell carcinoma

(2016) Zengchao Chen et al.   JOURNAL OF PATHOLOGY

Reversible Oligonucleotide Chain Blocking Enables Bead Capture and Amplification of T-Cell Receptor α and β Chain mRNAs

(2016) W. Miachel Hanson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Immunoscore and Immunoprofiling in cancer: an update from the melanoma and immunotherapy bridge 2015

(2016) J. Galon et al.   Journal of Translational Medicine

T cell receptor diversity in the human thymus

(2016) Reetta Vanhanen et al.   MOLECULAR IMMUNOLOGY

Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes

(2016) Amalie Kai Bentzen et al.   NATURE BIOTECHNOLOGY

Landscape of tumor-infiltrating T cell repertoire of human cancers

(2016) Bo Li et al.   NATURE GENETICS

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

(2016) Alena Gros et al.   NATURE MEDICINE

Diversity and divergence of the glioma-infiltrating T-cell receptor repertoire

(2016) Jennifer S. Sims et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of shared TCR sequences from T cells in human breast cancer using emulsion RT-PCR

(2016) Daniel J. Munson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct measurement of T cell receptor affinity and sequence from naïve antiviral T cells

(2016) Shu-Qi Zhang et al.   Science Translational Medicine

DNA demethylating agent decitabine broadens the peripheral T cell receptor repertoire

(2016) Jing Nie et al.   Oncotarget

Progressive changes in composition of lymphocytes in lung tissues from patients with non-small-cell lung cancer

(2016) María del Mar Valenzuela-Membrives et al.   Oncotarget

Single-cell TCRseq: paired recovery of entire T-cell alpha and beta chain transcripts in T-cell receptors from single-cell RNAseq

(2016) David Redmond et al.   Genome Medicine

Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor

(2016) A. Pasetto et al.   Cancer Immunology Research

Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials

(2016) Holbrook E. Kohrt et al.   Journal for ImmunoTherapy of Cancer

Advances in Cancer Immunotherapy in Solid Tumors

(2016) Smitha Menon et al.   Cancers

tcR: an R package for T cell receptor repertoire advanced data analysis

(2015) Vadim I. Nazarov et al.   BMC BIOINFORMATICS

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity

(2015) Michael S. Rooney et al.   CELL

Immunotherapy: The Path to Win the War on Cancer?

(2015)   CELL

TCR  repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition

(2015) H. M. Li et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Excess Cancers Among HIV-Infected People in the United States

(2015) Hilary A. Robbins et al.   JNCI-Journal of the National Cancer Institute

Pre-TCR ligand binding impacts thymocyte development before αβTCR expression

(2015) Robert J. Mallis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pre–T-cell receptor binds MHC: Implications for thymocyte signaling and selection

(2015) Xinbo Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

High-throughput pairing of T cell receptor α and β sequences

(2015) Bryan Howie et al.   Science Translational Medicine

Characteristics of Tumor Infiltrating Lymphocyte and Circulating Lymphocyte Repertoires in Pancreatic Cancer by the Sequencing of T Cell Receptors

(2015) Xueli Bai et al.   Scientific Reports

Excess Cancers Among HIV-Infected People in the United States

(2015) Hilary A. Robbins et al.   JNCI-Journal of the National Cancer Institute

Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens

(2015) Michael Hebeisen et al.   Frontiers in Immunology

Characterization of T cell repertoire of blood, tumor, and ascites in ovarian cancer patients using next generation sequencing

(2015) Miran Jang et al.   OncoImmunology

Peripheral T cell receptor diversity is associated with clinical outcomes following ipilimumab treatment in metastatic melanoma

(2015) Michael A. Postow et al.   Journal for ImmunoTherapy of Cancer

Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction

(2015) Paul L. Klarenbeek et al.   PLoS One

Multiplex Identification of Antigen-Specific T Cell Receptors Using a Combination of Immune Assays and Immune Receptor Sequencing

(2015) Mark Klinger et al.   PLoS One

Increased incidence of head and neck cancer in liver transplant recipients: a meta-analysis

(2014) Qian Liu et al.   BMC CANCER

Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions

(2014) Y.-C. Lu et al.   CLINICAL CANCER RESEARCH

CTLA4 Blockade Broadens the Peripheral T-Cell Receptor Repertoire

(2014) L. Robert et al.   CLINICAL CANCER RESEARCH

The immune contexture of primary and metastatic human tumours

(2014) Nicolas A Giraldo et al.   CURRENT OPINION IN IMMUNOLOGY

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Diversity and clonal selection in the human T-cell repertoire

(2014) Q. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response

(2014) P. Kvistborg et al.   Science Translational Medicine

Improved Survival with T Cell Clonotype Stability After Anti-CTLA-4 Treatment in Cancer Patients

(2014) E. Cha et al.   Science Translational Medicine

Tertiary lymphoid structures in cancer and beyond

(2014) Marie-Caroline Dieu-Nosjean et al.   TRENDS IN IMMUNOLOGY

Tumor-infiltrating lymphocytes in colorectal tumors display a diversity of T cell receptor sequences that differ from the T cells in adjacent mucosal tissue

(2013) Anna M. Sherwood et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunosequencing: applications of immune repertoire deep sequencing

(2013) Harlan Robins   CURRENT OPINION IN IMMUNOLOGY

Pairing of T-cell receptor chains via emulsion PCR

(2013) Maria A. Turchaninova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TCR repertoires of intratumoral T-cell subsets

(2013) Carsten Linnemann et al.   IMMUNOLOGICAL REVIEWS

Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas

(2013) Marco Gerlinger et al.   JOURNAL OF PATHOLOGY

High-throughput sequencing of T-cell receptors reveals a homogeneous repertoire of tumour-infiltrating lymphocytes in ovarian cancer

(2013) Ryan O Emerson et al.   JOURNAL OF PATHOLOGY

Combining Next-Generation Sequencing and Immune Assays: A Novel Method for Identification of Antigen-Specific T Cells

(2013) Mark Klinger et al.   PLoS One

Murine thymic selection quantified using a unique method to capture deleted T cells

(2013) G. L. Stritesky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling

(2013) Shuo Li et al.   Nature Communications

BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes

(2013) Zachary A Cooper et al.   OncoImmunology

Dissection of T-cell Antigen Specificity in Human Melanoma

(2012) R. S. Andersen et al.   CANCER RESEARCH

Adoptive Transfer of Autologous T Cells Improves T-cell Repertoire Diversity and Long-term B-cell Function in Pediatric Patients with Neuroblastoma

(2012) S. A. Grupp et al.   CLINICAL CANCER RESEARCH

Different affinity windows for virus and cancer-specific T-cell receptors: Implications for therapeutic strategies

(2012) Milos Aleksic et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lymphopenia combined with low TCR diversity (divpenia) predicts poor overall survival in metastatic breast cancer patients

(2012) Manuarii Manuel et al.   OncoImmunology

TIL therapy broadens the tumor-reactive CD8+T cell compartment in melanoma patients

(2012) Pia Kvistborg et al.   OncoImmunology

Natural Killer Cells are Scarce in Colorectal Carcinoma Tissue Despite High Levels of Chemokines and Cytokines

(2011) N. Halama et al.   CLINICAL CANCER RESEARCH

Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes

(2011) R. L. Warren et al.   GENOME RESEARCH

Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells

(2011) Mercedes B. Fuertes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

(2011) Mark S. Diamond et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antigen Receptor Allelic Exclusion: An Update and Reappraisal

(2010) B. L. Brady et al.   JOURNAL OF IMMUNOLOGY

Donor transmission of malignant melanoma in a lung transplant recipient 32 years after curative resection

(2010) Navkaranbir S. Bajaj et al.   TRANSPLANT INTERNATIONAL

Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment

(2009) H. Harlin et al.   CANCER RESEARCH

Donor transmission of malignant melanoma to a liver graft recipient: case report and literature review

(2009) Jason K. Kim et al.   CLINICAL TRANSPLANTATION

Molecular biology of the cell, 5th edition by B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, and P. Walter

(2008) John Boyle   BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION

NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy

(2008) Nadia Guerra et al.   IMMUNITY

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

(2008) Claude Sportès et al.   JOURNAL OF EXPERIMENTAL MEDICINE