GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival

SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair

(2019) Ming Tang et al.   Science Advances

The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair

(2019) Naike Salvador Moreno et al.   NUCLEIC ACIDS RESEARCH

Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair

(2018) Zhiming Li et al.   CELL RESEARCH

Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein

(2018) Maria Victoria Botuyan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein

(2018) Maria Victoria Botuyan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites

(2018) Sugiko Watanabe et al.   Scientific Reports

H3K9me3 and H4K20me3 represent the epigenetic landscape for 53BP1 binding to DNA lesions

(2018) Alena Svobodová Kovaříková et al.   Aging-US

TIRR regulates 53BP1 by masking its histone methyl-lysine binding function

(2017) Pascal Drané et al.   NATURE

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

(2017) Kenneth D Bromberg et al.   Nature Chemical Biology

G9a coordinates with the RPA complex to promote DNA damage repair and cell survival

(2017) Qiaoyan Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage

(2017) Vasudeva Ginjala et al.   Scientific Reports

G9a inhibition potentiates the anti-tumour activity of DNA double-strand break inducing agents by impairing DNA repair independent of p53 status

(2016) Pallavi Agarwal et al.   CANCER LETTERS

SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

(2016) Berta N Vazquez et al.   EMBO JOURNAL

Epigenome Maintenance in Response to DNA Damage

(2016) Juliette Dabin et al.   MOLECULAR CELL

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation

(2016) Karine Jacquet et al.   MOLECULAR CELL

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage

(2015) W. Wu et al.   CANCER RESEARCH

Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage

(2015) Takayo Fukuda et al.   CANCER SCIENCE

Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability

(2015) Nan Liu et al.   GENES & DEVELOPMENT

Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response

(2015) Ralph E Kleiner et al.   Nature Chemical Biology

ATM-mediated KDM2A phosphorylation is required for the DNA damage repair

(2015) L-L Cao et al.   ONCOGENE

ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT 2 Domain with γH2AX

(2015) Robert A. Baldock et al.   Cell Reports

DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin

(2014) M. K. Ayrapetov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance

(2014) Simran Khurana et al.   Cell Reports

Concerted Activities of Distinct H4K20 Methyltransferases at DNA Double-Strand Breaks Regulate 53BP1 Nucleation and NHEJ-Directed Repair

(2014) Creighton T. Tuzon et al.   Cell Reports

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair

(2013) K.-Y. Hsiao et al.   Journal of Molecular Cell Biology

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

(2012) Francesca Mattiroli et al.   CELL

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

(2012) Frédérick A Mallette et al.   EMBO JOURNAL

SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response

(2012) Andreas Mund et al.   NUCLEIC ACIDS RESEARCH

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

(2011) Huadong Pei et al.   NATURE

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

(2011) Jiri Lukas et al.   NATURE CELL BIOLOGY

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

(2011) Klara Acs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining

(2010) S. Fnu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D

(2010) Thomas Weiss et al.   Epigenetics & Chromatin

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

(2009) Grant S. Stewart et al.   CELL

The comet assay: A sensitive method for detecting DNA damage in individual cells

(2009) Wenjuan Liao et al.   METHODS

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

(2008) G. Schotta et al.   GENES & DEVELOPMENT

Preferential Dimethylation of Histone H4 Lysine 20 by Suv4-20

(2008) Hongbo Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules

(2008) Robert E Collins et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics