3-Hydroxy-3-Methylglutaric Acid Impairs Redox and Energy Homeostasis, Mitochondrial Dynamics, and Endoplasmic Reticulum–Mitochondria Crosstalk in Rat Brain

Experimental Evidence that In Vivo Intracerebral Administration of L-2-Hydroxyglutaric Acid to Neonatal Rats Provokes Disruption of Redox Status and Histopathological Abnormalities in the Brain

(2018) Rafael Teixeira Ribeiro et al.   NEUROTOXICITY RESEARCH

3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency: A Case Report and Literature Review

(2018) Ozlem Yilmaz et al.   Nutricion Hospitalaria

Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions

(2018) György Csordás et al.   TRENDS IN CELL BIOLOGY

A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease

(2018) Estela Area-Gomez et al.   Cell Death & Disease

Tau Phosphorylation, Molecular Chaperones, and Ubiquitin E3 Ligase: Clinical Relevance in Alzheimer's Disease

(2018) Pravir Kumar et al.   JOURNAL OF ALZHEIMERS DISEASE

Disruption of Brain Redox Homeostasis, Microglia Activation and Neuronal Damage Induced by Intracerebroventricular Administration of S-Adenosylmethionine to Developing Rats

(2018) Bianca Seminotti et al.   MOLECULAR NEUROBIOLOGY

Coupled brain and urine spectroscopy - in vivo metabolomic characterization of HMG-CoA lyase deficiency in 5 patients

(2017) Dominique Roland et al.   MOLECULAR GENETICS AND METABOLISM

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis

(2017) Keiko Imamura et al.   Science Translational Medicine

Enriched endoplasmic reticulum-mitochondria interactions result in mitochondrial dysfunction and apoptosis in oocytes from obese mice

(2017) Lihong Zhao et al.   Journal of Animal Science and Biotechnology

Mitochondria-associated membranes as hubs for neurodegeneration

(2016) Michiel Krols et al.   ACTA NEUROPATHOLOGICA

Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase

(2016) Haoling Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells

(2016) Ana I. Plácido et al.   MOLECULAR NEUROBIOLOGY

Increased oxidative stress in patients with 3-hydroxy-3-methylglutaric aciduria

(2015) Mariana dos Santos Mello et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Induction of a Proinflammatory Response in Cortical Astrocytes by the Major Metabolites Accumulating in HMG-CoA Lyase Deficiency: the Role of ERK Signaling Pathway in Cytokine Release

(2015) Carolina Gonçalves Fernandes et al.   MOLECULAR NEUROBIOLOGY

Intracerebral Glycine Administration Impairs Energy and Redox Homeostasis and Induces Glial Reactivity in Cerebral Cortex of Newborn Rats

(2015) Alana Pimentel Moura et al.   MOLECULAR NEUROBIOLOGY

NMDA Receptors and Oxidative Stress Induced by the Major Metabolites Accumulating in HMG Lyase Deficiency Mediate Hypophosphorylation of Cytoskeletal Proteins in Brain From Adolescent Rats: Potential Mechanisms Contributing to the Neuropathology of This Disease

(2015) Carolina Gonçalves Fernandes et al.   NEUROTOXICITY RESEARCH

Titanium Dioxide Nanoparticles Induce Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death via Mitochondria-Associated Endoplasmic Reticulum Membrane Disruption in Normal Lung Cells

(2015) Kyeong-Nam Yu et al.   PLoS One

Redox homeostasis is compromised in vivo by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency in rat cerebral cortex and liver

(2013) M. S. da Rosa et al.   FREE RADICAL RESEARCH

In vivo experimental evidence that the major metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency induce oxidative stress in striatum of developing rats: A potential pathophysiological mechanism of striatal damage in this disorder

(2013) Carolina Gonçalves Fernandes et al.   MOLECULAR GENETICS AND METABOLISM

Novel crosstalk between ERK MAPK and p38 MAPK leads to homocysteine-NMDA receptor-mediated neuronal cell death

(2012) Ranjana Poddar et al.   JOURNAL OF NEUROCHEMISTRY

An update on the role of mitochondrial α-ketoglutarate dehydrogenase in oxidative stress

(2012) Anatoly A. Starkov   MOLECULAR AND CELLULAR NEUROSCIENCE

Neonatal Astrocyte Damage Is Sufficient to Trigger Progressive Striatal Degeneration in a Rat Model of Glutaric Acidemia-I

(2011) Silvia Olivera-Bravo et al.   PLoS One

Neurochemical evidence that glycine induces bioenergetical dysfunction

(2010) Estela Natacha Brandt Busanello et al.   NEUROCHEMISTRY INTERNATIONAL

Homocysteine-NMDA receptor-mediated activation of extracellular signal-regulated kinase leads to neuronal cell death

(2009) Ranjana Poddar et al.   JOURNAL OF NEUROCHEMISTRY

Homocysteine-induced acute excitotoxicity in cerebellar granule cells in vitro is accompanied by PP2A-mediated dephosphorylation of tau

(2009) Magdalena Kuszczyk et al.   NEUROCHEMISTRY INTERNATIONAL

Detection of behavioral alterations and learning deficits in mice lacking synaptophysin

(2009) U. Schmitt et al.   NEUROSCIENCE

Glycine Provokes Lipid Oxidative Damage and Reduces the Antioxidant Defenses in Brain Cortex of Young Rats

(2008) Guilhian Leipnitz et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: A molecular mechanism leading to hepatic insulin resistance

(2008) J LIM et al.   CELLULAR SIGNALLING

Methylmalonate inhibits succinate-supported oxygen consumption by interfering with mitochondrial succinate uptake

(2008) S. R. Mirandola et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats

(2008) Guilhian Leipnitz et al.   LIFE SCIENCES

Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome

(2008) S. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence that 3-hydroxy-3-methylglutaric acid promotes lipid and protein oxidative damage and reduces the nonenzymatic antioxidant defenses in rat cerebral cortex

(2007) Guilhian Leipnitz et al.   JOURNAL OF NEUROSCIENCE RESEARCH