The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis
Authors
Keywords
-
Journal
Science Translational Medicine
Volume 9, Issue 391, Pages eaaf3962
Publisher
American Association for the Advancement of Science (AAAS)
Online
2017-05-25
DOI
10.1126/scitranslmed.aaf3962
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Altered Subcellular Distribution of c-Abl in Alzheimer's Disease
- (2017) Zheng Jing et al. JOURNAL OF ALZHEIMERS DISEASE
- Tau Phosphorylated at Tyrosine 394 is Found in Alzheimer's Disease Tangles and can be a Product of the Abl-Related Kinase, Arg
- (2017) Matthew A. Tremblay et al. JOURNAL OF ALZHEIMERS DISEASE
- The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis
- (2015) Takao Fujisawa et al. HUMAN MOLECULAR GENETICS
- Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability
- (2015) Anna-Claire Devlin et al. Nature Communications
- Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9
- (2015) Hongmei Lisa Li et al. Stem Cell Reports
- Modeling ALS with iPSCs Reveals that Mutant SOD1 Misregulates Neurofilament Balance in Motor Neurons
- (2014) Hong Chen et al. Cell Stem Cell
- Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1
- (2014) Evangelos Kiskinis et al. Cell Stem Cell
- c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease
- (2014) Anne-Laure Mahul-Mellier et al. HUMAN MOLECULAR GENETICS
- Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice
- (2014) Chen Wenqiang et al. HUMAN MOLECULAR GENETICS
- A Computational Model of Motor Neuron Degeneration
- (2014) Gwendal Le Masson et al. NEURON
- Delivery of Full-Length Factor VIII Using a piggyBac Transposon Vector to Correct a Mouse Model of Hemophilia A
- (2014) Hideto Matsui et al. PLoS One
- Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients
- (2014) Yu-Sheng Fang et al. Nature Communications
- Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons
- (2014) Brian J. Wainger et al. Cell Reports
- A Small Molecule Screen in Stem-Cell-Derived Motor Neurons Identifies a Kinase Inhibitor as a Candidate Therapeutic for ALS
- (2013) Yin M. Yang et al. Cell Stem Cell
- Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
- (2013) Takayuki Kondo et al. Cell Stem Cell
- A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells
- (2013) Matthew F. Burkhardt et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Parkin Plays a Role in Sporadic Parkinson's Disease
- (2013) Ted M. Dawson et al. Neurodegenerative Diseases
- RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention
- (2013) Christopher J. Donnelly et al. NEURON
- Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
- (2013) Shuo-Chien Ling et al. NEURON
- C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice
- (2013) C. S. Lobsiger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deciphering amyotrophic lateral sclerosis: What phenotype, neuropathology and genetics are telling us about pathogenesis
- (2013) John Ravits et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants
- (2012) Takao Fujisawa et al. ANNALS OF NEUROLOGY
- An update on dual Src/Abl inhibitors
- (2012) Francesca Musumeci et al. Future Medicinal Chemistry
- EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans
- (2012) Annelies Van Hoecke et al. NATURE MEDICINE
- Selective kinase inhibitors as tools for neuroscience research
- (2012) Kirsty J. Martin et al. NEUROPHARMACOLOGY
- c-Abl Inhibition Delays Motor Neuron Degeneration in the G93A Mouse, an Animal Model of Amyotrophic Lateral Sclerosis
- (2012) Ryu Katsumata et al. PLoS One
- Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
- (2012) B. Bilican et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS
- (2012) T. E. Brotherton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells
- (2012) N. Egawa et al. Science Translational Medicine
- An Efficient Nonviral Method to Generate Integration-Free Human-Induced Pluripotent Stem Cells from Cord Blood and Peripheral Blood Cells
- (2012) Keisuke Okita et al. STEM CELLS
- Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients
- (2011) Miguel Mitne-Neto et al. HUMAN MOLECULAR GENETICS
- c-Abl in Neurodegenerative Disease
- (2011) Sarah D. Schlatterer et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Rapid and Efficient Generation of Functional Motor Neurons From Human Pluripotent Stem Cells Using Gene Delivered Transcription Factor Codes
- (2011) Mark E Hester et al. MOLECULAR THERAPY
- Direct Observation of Defects and Increased Ion Permeability of a Membrane Induced by Structurally Disordered Cu/Zn-Superoxide Dismutase Aggregates
- (2011) Inhee Choi et al. PLoS One
- Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS
- (2010) Francois Gros-Louis et al. JOURNAL OF NEUROCHEMISTRY
- piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
- (2009) Knut Woltjen et al. NATURE
- Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome
- (2009) Noemi FUSAKI et al. PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More