Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination

Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor

(2019) O Sascha Yousefi et al.   eLife

Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling

(2019) Doug K Tischer et al.   eLife

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT

(2018) Wan-Lin Lo et al.   NATURE IMMUNOLOGY

Monomeric TCRs drive T cell antigen recognition

(2018) Mario Brameshuber et al.   NATURE IMMUNOLOGY

TCR Signaling: Mechanisms of Initiation and Propagation

(2018) Adam H. Courtney et al.   TRENDS IN BIOCHEMICAL SCIENCES

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

(2018) Neel H Shah et al.   eLife

Molecular mechanisms of T cell sensitivity to antigen

(2018) Jesús A. Siller-Farfán et al.   IMMUNOLOGICAL REVIEWS

Dynamic allostery can drive cold adaptation in enzymes

(2018) Harry G. Saavedra et al.   NATURE

Identifying feasible operating regimes for early T-cell recognition: The speed, energy, accuracy trade-off in kinetic proofreading and adaptive sorting

(2018) Wenping Cui et al.   PLoS One

Phosphorylation of a Tyrosine Residue on Zap70 by Lck and Its Subsequent Binding via an SH2 Domain May Be a Key Gatekeeper of T Cell Receptor SignalingIn Vivo

(2016) Peter A. Thill et al.   MOLECULAR AND CELLULAR BIOLOGY

System-wide Analysis of the T Cell Response

(2016) Ruxandra Covacu et al.   Cell Reports

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

(2016) Neel H Shah et al.   eLife

The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters

(2015) Lakshmi Balagopalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance

(2014) Ondrej Stepanek et al.   CELL

Insights into the initiation of TCR signaling

(2014) Arup K Chakraborty et al.   NATURE IMMUNOLOGY

Cold Adaptation: Structural and Functional Characterizations of Psychrophilic and Mesophilic Acetate Kinase

(2014) Md. Abul Kashem Tang et al.   PROTEIN JOURNAL

T cell immunodominance is dictated by the positively selecting self-peptide

(2014) Wan-Lin Lo et al.   eLife

A Single Peptide-Major Histocompatibility Complex Ligand Triggers Digital Cytokine Secretion in CD4+ T Cells

(2013) Jun Huang et al.   IMMUNITY

A Phospholipase C- 1-Independent, RasGRP1-ERK-Dependent Pathway Drives Lymphoproliferative Disease in Linker for Activation of T Cells-Y136F Mutant Mice

(2012) R. L. Kortum et al.   JOURNAL OF IMMUNOLOGY

The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation

(2012) Rebekah R. Bartelt et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling

(2011) J. R. Schoenborn et al.   Science Signaling

Computational analysis of T cell receptor signaling and ligand discrimination - Past, present, and future

(2010) Ronald N. Germain   FEBS LETTERS

Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection

(2010) Jeremy Juang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-Cell Signaling Regulated by the Tec Family Kinase, Itk

(2010) A. H. Andreotti et al.   Cold Spring Harbor Perspectives in Biology

The Essential Role of LAT in Thymocyte Development during Transition from the Double-Positive to Single-Positive Stage

(2009) S. Shen et al.   JOURNAL OF IMMUNOLOGY

Origin and evolution of the adaptive immune system: genetic events and selective pressures

(2009) Martin F. Flajnik et al.   NATURE REVIEWS GENETICS

Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice

(2009) M. Miyaji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Database resources of the National Center for Biotechnology Information

(2008) E. W. Sayers et al.   NUCLEIC ACIDS RESEARCH

Quantitative challenges in understanding ligand discrimination by αβ T cells

(2007) Ofer Feinerman et al.   MOLECULAR IMMUNOLOGY