Pass-back chain extension expands multimodular assembly line biosynthesis

Module and individual domain deletions of NRPS to produce plipastatin derivatives in Bacillus subtilis

(2018) Ling Gao et al.   Microbial Cell Factories

De novo design and engineering of non-ribosomal peptide synthetases

(2017) Kenan A. J. Bozhüyük et al.   Nature Chemistry

X-Ray Crystallography and Electron Microscopy of Cross- and Multi-Module Nonribosomal Peptide Synthetase Proteins Reveal a Flexible Architecture

(2017) Michael J. Tarry et al.   STRUCTURE

Family-wide Structural Characterization and Genomic Comparisons Decode the Diversity-oriented Biosynthesis of Thalassospiramides by Marine Proteobacteria

(2016) Weipeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture

(2016) Bradley R. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A structural model for multimodular NRPS assembly lines

(2016) Mohamed A. Marahiel   NATURAL PRODUCT REPORTS

Biosynthesis of polyketides by trans-AT polyketide synthases

(2016) Eric J. N. Helfrich et al.   NATURAL PRODUCT REPORTS

Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

(2016) Eric J. Drake et al.   NATURE

Synthetic cycle of the initiation module of a formylating nonribosomal peptide synthetase

(2016) Janice M. Reimer et al.   NATURE

Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining

(2015) Xiaoyu Tang et al.   ACS Chemical Biology

Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase

(2015) Takayoshi Awakawa et al.   CHEMBIOCHEM

Interrupted adenylation domains: unique bifunctional enzymes involved in nonribosomal peptide biosynthesis

(2015) Kristin J. Labby et al.   NATURAL PRODUCT REPORTS

The structural biology of biosynthetic megaenzymes

(2015) Kira J Weissman   Nature Chemical Biology

Comparative Analysis of the Substrate Specificity of trans- versus cis-Acyltransferases of Assembly Line Polyketide Synthases

(2014) Briana J. Dunn et al.   BIOCHEMISTRY

Architectures of Whole-Module and Bimodular Proteins from the 6-Deoxyerythronolide B Synthase

(2014) Andrea L. Edwards et al.   JOURNAL OF MOLECULAR BIOLOGY

Adenylation and S-Methylation of Cysteine by the Bifunctional Enzyme TioN in Thiocoraline Biosynthesis

(2014) Ahmad H. Al-Mestarihi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pseudomonas 2.0: genetic upgrading of P. putida KT2440 as an enhanced host for heterologous gene expression

(2014) Esteban Martínez-García et al.   Microbial Cell Factories

Structure of a modular polyketide synthase

(2014) Somnath Dutta et al.   NATURE

Structural rearrangements of a polyketide synthase module during its catalytic cycle

(2014) Jonathan R. Whicher et al.   NATURE

Analysis of the linker region joining the adenylation and carrier protein domains of the modular nonribosomal peptide synthetases

(2014) Bradley R. Miller et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Insights into the function of trans-acyl transferase polyketide synthases from the SAXS structure of a complete module

(2014) Jack Davison et al.   Chemical Science

A New Large-DNA-Fragment Delivery System Based on Integrase Activity from an Integrative and Conjugative Element

(2013) R. Miyazaki et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

(2013) Wenyan Jiang et al.   NATURE BIOTECHNOLOGY

Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity

(2012) Jenny Thirlway et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vivo Characterization of Nonribosomal Peptide Synthetases NocA and NocB in the Biosynthesis of Nocardicin A

(2012) Jeanne M. Davidsen et al.   CHEMISTRY & BIOLOGY

Biosynthetic Multitasking Facilitates Thalassospiramide Structural Diversity in Marine Bacteria

(2012) Avena C. Ross et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The structural role of the carrier protein – active controller or passive carrier

(2012) John Crosby et al.   NATURAL PRODUCT REPORTS

Programming of Erythromycin Biosynthesis by a Modular Polyketide Synthase

(2010) David E. Cane   JOURNAL OF BIOLOGICAL CHEMISTRY

Daptomycin, a Bacterial Lipopeptide Synthesized by a Nonribosomal Machinery

(2010) Lars Robbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway

(2010) David L. Akey et al.   STRUCTURE

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

(2008) Adrian Keatinge-Clay   JOURNAL OF MOLECULAR BIOLOGY

A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both  - and  -ketone reduction during chain growth

(2008) C. T. Calderone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase

(2008) A. Tanovic et al.   SCIENCE