The structural biology of biosynthetic megaenzymes

Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry

(2015) Thibault Annaval et al.   CHEMBIOCHEM

Architecture of the polyketide synthase module: surprises from electron cryo-microscopy

(2015) Janet L Smith et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Uncovering the structures of modular polyketide synthases

(2015) Kira J. Weissman   NATURAL PRODUCT REPORTS

Structure of the terminal PCP domain of the non-ribosomal peptide synthetase in teicoplanin biosynthesis

(2015) Kristina Haslinger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structure of the adenylation–peptidyl carrier protein didomain of theMicrocystis aeruginosamicrocystin synthetase McyG

(2015) Xiao-Feng Tan et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Double-Hotdog with a New Trick: Structure and Mechanism of the trans-Acyltransferase Polyketide Synthase Enoyl-isomerase

(2014) Darren C. Gay et al.   ACS Chemical Biology

Modular Polyketide Synthases (PKSs): A New Model Fits All?

(2014) Alexander Rittner et al.   CHEMBIOCHEM

Crystal Structure of a PCP/Sfp Complex Reveals the Structural Basis for Carrier Protein Posttranslational Modification

(2014) Peter Tufar et al.   CHEMISTRY & BIOLOGY

Architectures of Whole-Module and Bimodular Proteins from the 6-Deoxyerythronolide B Synthase

(2014) Andrea L. Edwards et al.   JOURNAL OF MOLECULAR BIOLOGY

Elucidation of the Cryptic Epimerase Activity of Redox-Inactive Ketoreductase Domains from Modular Polyketide Synthases by Tandem Equilibrium Isotope Exchange

(2014) Ashish Garg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of a modular polyketide synthase

(2014) Somnath Dutta et al.   NATURE

Structural rearrangements of a polyketide synthase module during its catalytic cycle

(2014) Jonathan R. Whicher et al.   NATURE

Structural and functional studies of a trans -acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction

(2014) Shawn K. Piasecki et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A Close Look at a Ketosynthase from a Trans-Acyltransferase Modular Polyketide Synthase

(2014) Darren C. Gay et al.   STRUCTURE

Insights into the function of trans-acyl transferase polyketide synthases from the SAXS structure of a complete module

(2014) Jack Davison et al.   Chemical Science

Structure of the epimerization domain of tyrocidine synthetase A

(2014) Stefan A. Samel et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent Stereochemistry

(2013) Jianting Zheng et al.   ACS Chemical Biology

The Missing Linker: A Dimerization Motif Located within Polyketide Synthase Modules

(2013) Jianting Zheng et al.   ACS Chemical Biology

Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene

(2013) Shilah A. Bonnett et al.   CHEMISTRY & BIOLOGY

Cyanobacterial Polyketide Synthase Docking Domains: A Tool for Engineering Natural Product Biosynthesis

(2013) Jonathan R. Whicher et al.   CHEMISTRY & BIOLOGY

Crystal Structures of the First Condensation Domain of CDA Synthetase Suggest Conformational Changes during the Synthetic Cycle of Nonribosomal Peptide Synthetases

(2013) Kristjan Bloudoff et al.   JOURNAL OF MOLECULAR BIOLOGY

Vinylogous chain branching catalysed by a dedicated polyketide synthase module

(2013) Tom Bretschneider et al.   NATURE

A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis

(2013) Anthony S Haines et al.   Nature Chemical Biology

The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins

(2013) Jeremy R. Lohman et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity

(2012) Jenny Thirlway et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure of PA1221, a Nonribosomal Peptide Synthetase Containing Adenylation and Peptidyl Carrier Protein Domains

(2012) Carter A. Mitchell et al.   BIOCHEMISTRY

Structural and Functional Investigation of the Intermolecular Interaction between NRPS Adenylation and Carrier Protein Domains

(2012) Jesse A. Sundlov et al.   CHEMISTRY & BIOLOGY

Structural analysis of protein–protein interactions in type I polyketide synthases

(2012) Wei Xu et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Divergence of multimodular polyketide synthases revealed by a didomain structure

(2012) Jianting Zheng et al.   Nature Chemical Biology

Characterization of Molecular Interactions between ACP and Halogenase Domains in the Curacin A Polyketide Synthase

(2011) Alena Busche et al.   ACS Chemical Biology

Structure and Mechanism of thetrans-Acting Acyltransferase from the Disorazole Synthase

(2011) Fong T. Wong et al.   BIOCHEMISTRY

Structural Basis for Phosphopantetheinyl Carrier Domain Interactions in the Terminal Module of Nonribosomal Peptide Synthetases

(2011) Ye Liu et al.   CHEMISTRY & BIOLOGY

Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis

(2011) Jennifer J. Gehret et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Analysis of C2-Type Ketoreductases from Modular Polyketide Synthases

(2011) Jianting Zheng et al.   JOURNAL OF MOLECULAR BIOLOGY

NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

(2011) Marc Röttig et al.   NUCLEIC ACIDS RESEARCH

Biochemical and Structural Characterization of the Tautomycetin Thioesterase: Analysis of a Stereoselective Polyketide Hydrolase

(2010) Jamie B. Scaglione et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Nonribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis,

(2010) Eric J. Drake et al.   BIOCHEMISTRY

Insights into Protein-Protein and Enzyme-Substrate Interactions in Modular Polyketide Synthases

(2010) Lucky Tran et al.   CHEMISTRY & BIOLOGY

Nonribosomal peptide synthetases: structures and dynamics

(2010) Matthias Strieker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mechanism of Substrate Shuttling by the Acyl-Carrier Protein within the Fatty Acid Mega-Synthase

(2010) Claudio Anselmi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway

(2010) David L. Akey et al.   STRUCTURE

Structural and Functional Analysis of A-Type Ketoreductases from the Amphotericin Modular Polyketide Synthase

(2010) Jianting Zheng et al.   STRUCTURE

Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-ribosomal Peptide Synthetases, and Firefly Luciferase

(2009) Andrew M. Gulick   ACS Chemical Biology

Structural Basis for Binding Specificity between Subclasses of Modular Polyketide Synthase Docking Domains

(2009) Tonia J. Buchholz et al.   ACS Chemical Biology

Crystal Structure of Bacillus cereus d-Alanyl Carrier Protein Ligase (DltA) in Complex with ATP

(2009) Khan Tanjid Osman et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

(2008) Adrian Keatinge-Clay   JOURNAL OF MOLECULAR BIOLOGY

Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase

(2008) Dominique P. Frueh et al.   NATURE

Structural basis for the selectivity of the external thioesterase of the surfactin synthetase

(2008) Alexander Koglin et al.   NATURE

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

(2008) TuAnh Nguyen et al.   NATURE BIOTECHNOLOGY

The Crystal Structure of a Mammalian Fatty Acid Synthase

(2008) T. Maier et al.   SCIENCE

Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase

(2008) A. Tanovic et al.   SCIENCE