The Role of Secretase Pathway in Long-term Brain Inflammation and Cognitive Impairment in an Animal Model of Severe Sepsis

Relationships between markers of neurologic and endothelial injury during critical illness and long-term cognitive impairment and disability

(2018) Christopher G. Hughes et al.   INTENSIVE CARE MEDICINE

Predicting Long-term Cognitive Dysfunction in Survivors of Critical Illness with Plasma Inflammatory Markers: a Retrospective Cohort Study

(2018) Marcus Maciel et al.   MOLECULAR NEUROBIOLOGY

Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment

(2017) Juciano Gasparotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model

(2017) Daisuke Tanokashira et al.   Molecular Brain

Assessment of Clinical Criteria for Sepsis

(2016) Christopher W. Seymour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF

(2016) Ying Jiang et al.   NEUROBIOLOGY OF AGING

Cecal Ligation and Puncture Results in Long-Term Central Nervous System Myeloid Inflammation

(2016) Benjamin H. Singer et al.   PLoS One

The role of microglia activation in the development of sepsis-induced long-term cognitive impairment

(2015) Monique Michels et al.   BRAIN BEHAVIOR AND IMMUNITY

Role of RAGE in Alzheimer’s Disease

(2015) Zhiyou Cai et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Systemic inflammation and microglial activation: systematic review of animal experiments

(2015) Inge C.M. Hoogland et al.   Journal of Neuroinflammation

Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing

(2015) Emily D. Niederst et al.   MOLECULAR BIOLOGY OF THE CELL

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

(2015) Ulf Neumann et al.   Molecular Neurodegeneration

Systemic Inflammation and the Brain: Novel Roles of Genetic, Molecular, and Environmental Cues as Drivers of Neurodegeneration

(2015) Roman Sankowski et al.   Frontiers in Cellular Neuroscience

Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research

(2015) Colm Cunningham et al.   Alzheimers Research & Therapy

Does Infection-Induced Immune Activation Contribute to Dementia?

(2015) Tatiana Barichello et al.   Aging and Disease

Toll-Like Receptor 2 and NLRP3 Cooperate To Recognize a Functional Bacterial Amyloid, Curli

(2014) Glenn J. Rapsinski et al.   INFECTION AND IMMUNITY

Prolonged Neuroinflammation after Lipopolysaccharide Exposure in Aged Rats

(2014) Hui Qun Fu et al.   PLoS One

Il1-β Involvement in Cognitive Impairment after Sepsis

(2013) Francielle Mina et al.   MOLECULAR NEUROBIOLOGY

Acute Brain Inflammation and Oxidative Damage Are Related to Long-Term Cognitive Deficits and Markers of Neurodegeneration in Sepsis-Survivor Rats

(2013) Mágada T. Schwalm et al.   MOLECULAR NEUROBIOLOGY

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

First-in-human study of E2609, a novel BACE1 inhibitor, demonstrates prolonged reductions in plasma beta-amyloid levels after single dosing

(2012) Robert Lai et al.   Alzheimers & Dementia

Protective effects of guanosine against sepsis-induced damage in rat brain and cognitive impairment

(2012) Fabricia Petronilho et al.   BRAIN BEHAVIOR AND IMMUNITY

Cdk5 Protein Inhibition and Aβ42 Increase BACE1 Protein Level in Primary Neurons by a Post-transcriptional Mechanism

(2012) Katherine R. Sadleir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2012) Sangeeta Chavan et al.   MOLECULAR MEDICINE

BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease

(2012) Linda Chami et al.   Molecular Neurodegeneration

Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates

(2012) Jonas Hannestad et al.   NEUROIMAGE

Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease

(2011) Maria Teresa Ferretti et al.   NEUROBIOLOGY OF AGING

Inhibitory Role of Notch1 in Calcific Aortic Valve Disease

(2011) Asha Acharya et al.   PLoS One

Toll-like receptors 1 and 2 cooperatively mediate immune responses to curli, a common amyloid from enterobacterial biofilms

(2010) Çagla Tükel et al.   CELLULAR MICROBIOLOGY

Delirium as a predictor of long-term cognitive impairment in survivors of critical illness

(2010) Timothy D. Girard et al.   CRITICAL CARE MEDICINE

Cognitive Impairment in the Septic Brain

(2009) Clarissa Comim et al.   CURRENT NEUROVASCULAR RESEARCH

Alzheimer's-related endosome dysfunction in Down syndrome is A -independent but requires APP and is reversed by BACE-1 inhibition

(2009) Y. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Time-dependent behavioral recovery after sepsis in rats

(2008) Lisiane Tuon et al.   INTENSIVE CARE MEDICINE