New uracil analogs as downregulators of ABC transporters in 5-fluorouracil-resistant human leukemia HL-60 cell line

Mechanisms of drug resistance in acute myeloid leukemia

(2019) Jing Zhang et al.   OncoTargets and Therapy

Enantioselective synthesis of 5-methylidenedihydrouracils as potential anticancer agents

(2019) Marlena Pięta et al.   TETRAHEDRON

Chemo-enzymatic synthesis of the exocyclic olefin isomer of thymidine monophosphate

(2018) Dibyendu Mondal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mechanism of Action of ABC Importers: Conservation, Divergence, and Physiological Adaptations

(2017) Oded Lewinson et al.   JOURNAL OF MOLECULAR BIOLOGY

Suppression of ABCG2 mediated MDR in vitro and in vivo by a novel inhibitor of ABCG2 drug transport

(2017) Atish Patel et al.   PHARMACOLOGICAL RESEARCH

The role of MRP1 in the multidrug resistance of colorectal cancer

(2017) Dongxing Cao et al.   Oncology Letters

Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles

(2017) Vanessa Lopes-Rodrigues et al.   Scientific Reports

ABC Transporters in the Development of Multidrug Resistance in Cancer Therapy

(2016) Angelika Dlugosz et al.   CURRENT PHARMACEUTICAL DESIGN

Synergistic anticancer properties of docosahexaenoic acid and 5-fluorouracil through interference with energy metabolism and cell cycle arrest in human gastric cancer cell line AGS cells

(2016) Kun Gao et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Proapoptotic activity and ABCC1-related multidrug resistance reduction ability of semisynthetic oleanolic acid derivatives DIOXOL and HIMOXOL in human acute promyelocytic leukemia cells

(2015) A. Paszel-Jaworska et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effects of 5-Fluorouracil on Morphology, Cell Cycle, Proliferation, Apoptosis, Autophagy and ROS Production in Endothelial Cells and Cardiomyocytes

(2015) Chiara Focaccetti et al.   PLoS One

Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?

(2014) C. S. Grove et al.   Disease Models & Mechanisms

Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter

(2014) Susan P. C. Cole   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical impact ofABCC1andABCC2genotypes and haplotypes in mediating imatinib resistance among chronic myeloid leukaemia patients

(2014) A. Au et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function

(2014) Frances Jane Sharom   Frontiers in Oncology

Different strategies to overcome multidrug resistance in cancer

(2013) Manju Saraswathy et al.   BIOTECHNOLOGY ADVANCES

Combined 5-FU and ChoKα Inhibitors as a New Alternative Therapy of Colorectal Cancer: Evidence in Human Tumor-Derived Cell Lines and Mouse Xenografts

(2013) Ana de la Cueva et al.   PLoS One

Heterocycles in drugs and drug discovery

(2012) A. Gomtsyan   Chemistry of Heterocyclic Compounds

Multidrug Resistance ABC Transporter Structure Predictions by Homology Modeling Approaches

(2011) Mylene Honorat et al.   CURRENT DRUG METABOLISM

The controversial role of ABC transporters in clinical oncology

(2011) Akina Tamaki et al.   Essays in Biochemistry

Down-regulation of microRNA-200c is associated with drug resistance in human breast cancer

(2011) Junqing Chen et al.   MEDICAL ONCOLOGY

Nuclear translocation of MRP1 contributes to multidrug resistance of mucoepidermoid carcinoma

(2011) Bo-Lei Cai et al.   ORAL ONCOLOGY

Breast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expression

(2011) Takeo Nakanishi et al.   Chinese Journal of Cancer

Emerging role for drug transporters at the blood–testis barrier

(2010) Dolores D. Mruk et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

P-glycoprotein substrate transport assessed by comparing cellular and vesicular ATPase activity

(2009) Pierluigi Nervi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Role of oxidative stress and intracellular glutathione in the sensitivity to apoptosis induced by proteasome inhibitor in thyroid cancer cells

(2009) Zhen-Xian Du et al.   BMC CANCER

ABC Transporters, Drug Resistance, and Cancer Stem Cells

(2009) Michael Dean   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Mechanisms of Chemotherapeutic Drug Resistance in Cancer Therapy—A Quick Review

(2009) Fu-Shing Liu   Taiwanese Journal of Obstetrics & Gynecology

Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia

(2008) Lorena L. de Figueiredo-Pontes et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY