SOAT1 methylation is associated with coronary heart disease

A genetic variant c.553G > T (rs2075291) in the apolipoprotein A5 gene is associated with altered triglycerides levels in coronary artery disease (CAD) patients with lipid lowering drug

(2019) Neda M. Bogari et al.   BMC Cardiovascular Disorders

SOAT1 deficiency attenuates atherosclerosis by regulating inflammation and cholesterol transportation via HO-1 pathway

(2018) Nan Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O -acyltransferase (ACAT/SOAT) inhibitors

(2018) Kimiyuki Shibuya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Callyspongiamides A and B, sterol O -acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp.

(2018) Magie M. Kapojos et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cholesterol esterification inhibition and gemcitabine synergistically suppress pancreatic ductal adenocarcinoma proliferation

(2018) Junjie Li et al.   PLoS One

ALIMA1variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption

(2018) Ying-Yu Zhang et al.   SCIENCE

Cholesterol: A Gatekeeper of Male Fertility?

(2018) Lauriane Sèdes et al.   Frontiers in Endocrinology

Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity

(2018) Prachi Jain et al.   STEM CELLS

Low-density lipoprotein cholesterol target attainment in patients with stable or acute coronary heart disease in the Asia-Pacific region: results from the Dyslipidemia International Study II

(2018) Kian-Keong Poh et al.   European Journal of Preventive Cardiology

Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6)

(2018) Emre Karakus et al.   Frontiers in Pharmacology

Rheumatoid arthritis–associated DNA methylation sites in peripheral blood mononuclear cells

(2018) Hong Zhu et al.   ANNALS OF THE RHEUMATIC DISEASES

Impact of genetic variation on pravastatin systemic exposure in pediatric hypercholesterolemia

(2018) Jonathan B. Wagner et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cholesterol transport system: An integrated cholesterol transport model involved in atherosclerosis

(2018) Xiao-Hua Yu et al.   PROGRESS IN LIPID RESEARCH

Impact of genetic testing on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia (GenTLe-FH): a randomised waiting list controlled open-label study protocol

(2018) Akihiro Nomura et al.   BMJ Open

Genetic variations in familial hypercholesterolemia and cascade screening in East Asians

(2018) Melody Lok-Yi Chan et al.   Molecular Genetics & Genomic Medicine

Association between serum selenium level and the prevalence of diabetes mellitus in U.S. population

(2018) Shinje Moon et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Mathematical models of DNA methylation dynamics: Implications for health and ageing

(2018) Loukas Zagkos et al.   JOURNAL OF THEORETICAL BIOLOGY

DNA methylation of candidate genes in peripheral blood from patients with type 2 diabetes or the metabolic syndrome

(2017) Sanne D. van Otterdijk et al.   PLoS One

Epigenetics of Atherosclerosis: Emerging Mechanisms and Methods

(2017) Nadiya Khyzha et al.   TRENDS IN MOLECULAR MEDICINE

Discovery of SOAT2 inhibitors from synthetic small molecules

(2016) Keisuke Kobayashi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Role of DNA Methylation in Cardiovascular Risk and Disease

(2016) Jia Zhong et al.   CIRCULATION RESEARCH

Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis

(2016) F. Geng et al.   CLINICAL CANCER RESEARCH

DNA methylation of loci withinABCG1andPHOSPHO1in blood DNA is associated with future type 2 diabetes risk

(2016) Tasnim Dayeh et al.   Epigenetics

ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease

(2015) Yohei Shibuya et al.   Future Medicinal Chemistry

The association of cholesterol absorption gene Numb polymorphism with Coronary Artery Disease among Han Chinese and Uighur Chinese in Xinjiang, China

(2015) Mayila Abudoukelimu et al.   Lipids in Health and Disease

Volume and functional outcome of intracerebral hemorrhage according to oral anticoagulant type

(2015) Duncan Wilson et al.   NEUROLOGY

Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2–MALT1 in MALT lymphoma

(2015) Zilin Nie et al.   Nature Communications

Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases A 1-42 Clearance

(2014) Y. Shibuya et al.   JOURNAL OF NEUROSCIENCE

Downregulation of miR-138 Sustains NF- B Activation and Promotes Lipid Raft Formation in Esophageal Squamous Cell Carcinoma

(2013) H. Gong et al.   CLINICAL CANCER RESEARCH

Focused, high accuracy 5-methylcytosine quantitation with base resolution by benchtop next-generation sequencing

(2013) Dustin R Masser et al.   Epigenetics & Chromatin

Sterol O-Acyltransferase 1 (SOAT1, ACAT) Is a Novel Target of Steroidogenic Factor-1 (SF-1, NR5A1, Ad4BP) in the Human Adrenal

(2011) Bruno Ferraz-de-Souza et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM