Medulloblastoma in the age of molecular subgroups: a review

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma

(2019) Catherine Lee et al.   Nature Communications

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases

(2018) Livia Garzia et al.   CELL

Survival Following Tumor Recurrence in Children With Medulloblastoma

(2018) Donna L. Johnston et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

(2018) Sebastian M Waszak et al.   LANCET ONCOLOGY

Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial

(2018) Giles W Robinson et al.   LANCET ONCOLOGY

Targeting the PI3K pathway in cancer: are we making headway?

(2018) Filip Janku et al.   Nature Reviews Clinical Oncology

Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma

(2018) Teresa Purzner et al.   Science Signaling

Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study

(2017) Edward C Schwalbe et al.   LANCET ONCOLOGY

The whole-genome landscape of medulloblastoma subtypes

(2017) Paul A. Northcott et al.   NATURE

Medulloblastoma in children and adolescents: a systematic review of contemporary phase I and II clinical trials and biology update

(2017) Francisco Bautista et al.   Cancer Medicine

Risk stratification of childhood medulloblastoma in the molecular era: the current consensus

(2016) Vijay Ramaswamy et al.   ACTA NEUROPATHOLOGICA

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

A Recurrent Mosaic Mutation in SMO , Encoding the Hedgehog Signal Transducer Smoothened, Is the Major Cause of Curry-Jones Syndrome

(2016) Stephen R.F. Twigg et al.   AMERICAN JOURNAL OF HUMAN GENETICS

HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC- Driven Medulloblastoma

(2016) Yanxin Pei et al.   CANCER CELL

Medulloblastoma stem cells: Promising targets in medulloblastoma therapy

(2016) Guo-Hao Huang et al.   CANCER SCIENCE

Medulloblastoma

(2016) Nathan E. Millard et al.   JOURNAL OF CHILD NEUROLOGY

Intellectual Outcome in Molecular Subgroups of Medulloblastoma

(2016) Iska Moxon-Emre et al.   JOURNAL OF CLINICAL ONCOLOGY

Treatment of Children and Adolescents With Metastatic Medulloblastoma and Prognostic Relevance of Clinical and Biologic Parameters

(2016) André O. von Bueren et al.   JOURNAL OF CLINICAL ONCOLOGY

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

(2016) Eric M Thompson et al.   LANCET ONCOLOGY

Long-term toxic effects of proton radiotherapy for paediatric medulloblastoma: a phase 2 single-arm study

(2016) Torunn I Yock et al.   LANCET ONCOLOGY

Divergent clonal selection dominates medulloblastoma at recurrence

(2016) A. Sorana Morrissy et al.   NATURE

BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression

(2016) Hengrui Zhu et al.   Cell Reports

Medulloblastoma subgroups remain stable across primary and metastatic compartments

(2015) Xin Wang et al.   ACTA NEUROPATHOLOGICA

From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation

(2015) T. Moroy et al.   BLOOD

Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment

(2015) T. VanArsdale et al.   CLINICAL CANCER RESEARCH

Panobinostat for the Treatment of Multiple Myeloma

(2015) J. P. Laubach et al.   CLINICAL CANCER RESEARCH

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

(2015) Giles W. Robinson et al.   JOURNAL OF CLINICAL ONCOLOGY

Survival of children with medulloblastoma in Canada diagnosed between 1990 and 2009 inclusive

(2015) Donna L. Johnston et al.   JOURNAL OF NEURO-ONCOLOGY

MRI Surrogates for Molecular Subgroups of Medulloblastoma

(2014) S. Perreault et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

(2014) Paul A. Northcott et al.   NATURE

BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma

(2013) P. Bandopadhayay et al.   CLINICAL CANCER RESEARCH

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

(2013) Vijay Ramaswamy et al.   LANCET ONCOLOGY

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

(2012) Marcel Kool et al.   ACTA NEUROPATHOLOGICA

Outcome of Children With Metastatic Medulloblastoma Treated With Carboplatin During Craniospinal Radiotherapy: A Children's Oncology Group Phase I/II Study

(2012) Regina I. Jakacki et al.   JOURNAL OF CLINICAL ONCOLOGY

High Frequency of Germline SUFU Mutations in Children With Desmoplastic/Nodular Medulloblastoma Younger Than 3 Years of Age

(2012) Laurence Brugières et al.   JOURNAL OF CLINICAL ONCOLOGY

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

(2012) Trevor J. Pugh et al.   NATURE

Novel mutations target distinct subgroups of medulloblastoma

(2012) Giles Robinson et al.   NATURE

Dissecting the genomic complexity underlying medulloblastoma

(2012) David T. W. Jones et al.   NATURE

Clonal selection drives genetic divergence of metastatic medulloblastoma

(2012) Xiaochong Wu et al.   NATURE

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

(2012) Paul A. Northcott et al.   NATURE

Survival and secondary tumors in children with medulloblastoma receiving radiotherapy and adjuvant chemotherapy: results of Children's Oncology Group trial A9961

(2012) Roger J. Packer et al.   NEURO-ONCOLOGY

Clinical and neuroanatomical predictors of cerebellar mutism syndrome

(2012) N. Law et al.   NEURO-ONCOLOGY

Molecular subgroups of medulloblastoma: the current consensus

(2011) Michael D. Taylor et al.   ACTA NEUROPATHOLOGICA

Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors

(2011) P. M. LoRusso et al.   CLINICAL CANCER RESEARCH

Adult Medulloblastoma Comprises Three Major Molecular Variants

(2011) Marc Remke et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome

(2010) Yoon-Jae Cho et al.   JOURNAL OF CLINICAL ONCOLOGY

Medulloblastoma Comprises Four Distinct Molecular Variants

(2010) Paul A. Northcott et al.   JOURNAL OF CLINICAL ONCOLOGY

Role of high-dose chemotherapy for recurrent medulloblastoma and other CNS primitive neuroectodermal tumors

(2010) Amar Gajjar et al.   PEDIATRIC BLOOD & CANCER

Management of and Prognosis With Medulloblastoma

(2008) Roger J. Packer et al.   ARCHIVES OF NEUROLOGY

Hyperfractionated Accelerated Radiotherapy in the Milan Strategy for Metastatic Medulloblastoma

(2008) Lorenza Gandola et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features

(2008) Marcel Kool et al.   PLoS One