Editorial Material
Clinical Neurology
Mohamad Bydon, Anshit Goyal, Panagiotis Kerezoudis
Summary: Intramedullary spinal cord tumors, accounting for 2-4% of all central nervous system tumors, are mainly treated by surgical resection with intraoperative neuromonitoring to prevent neurological decline. Some tumors may be difficult to definitively characterize, leading to challenges in treatment selection.
WORLD NEUROSURGERY
(2022)
Review
Biochemistry & Molecular Biology
Andras Piffko, Christian Uhl, Peter Vajkoczy, Marcus Czabanka, Thomas Broggini
Summary: EphrinB2-EphB4 signaling plays critical roles in embryogenesis and cancer pathologies. This signaling is involved in various cancer processes, such as migration, angiogenesis, and metastasis. However, the signaling pathways differ depending on the cancer type. This study explores the impact of these signaling pathways in neurooncological diseases, including glioma and brain metastasis, and seeks to understand their role in antiangiogenic therapy resistance, particularly in glioma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Sophie S. Wang, Friederike Selge, Martina Seboek, Pierre Scheffler, Yang Yang, Giovanna Brandi, Sebastian Winklhofer, Oliver Bozinov
Summary: Identifying tumor remnants in previously operated tumor lesions remains a challenge. Intraoperative MRI (ioMRI) may be less efficient in detecting tumor remnants in recurrent lesions compared to primary surgery, with a higher rate of false-positive ioMRI signals in the re-craniotomy group, mainly due to the inability to distinguish contrast enhancement from hyperacute hemorrhage. Further investigation into additional specific sequences in ioMRI to differentiate between the two should be considered in future studies.
JOURNAL OF NEUROSURGERY
(2021)
Article
Multidisciplinary Sciences
Zaili Luo, Mingyang Xia, Wei Shi, Chuntao Zhao, Jiajia Wang, Dazhuan Xin, Xinran Dong, Yu Xiong, Feng Zhang, Kalen Berry, Sean Ogurek, Xuezhao Liu, Rohit Rao, Rui Xing, Lai Man Natalie Wu, Siying Cui, Lingli Xu, Yifeng Lin, Wenkun Ma, Shuaiwei Tian, Qi Xie, Li Zhang, Mei Xin, Xiaotao Wang, Feng Yue, Haizi Zheng, Yaping Liu, Charles B. Stevenson, Peter de Blank, John P. Perentesis, Richard J. Gilbertson, Hao Li, Jie Ma, Wenhao Zhou, Michael D. Taylor, Q. Richard Lu
Summary: In this study, single-cell profiling of human fetal cerebella was performed to investigate the cellular states and regulatory networks in medulloblastomas (MBs). The researchers found a unique transitional cerebellar progenitor population enriched in aggressive MB subgroups and identified transcriptional determinants HNRNPH1 and SOX11 that are correlated with prognosis in group 3 MBs. Genomic analysis revealed long-range chromatin loops connecting HNRNPH1/SOX11-targeted super-enhancers to regulatory elements of the oncogenic driver MYC in group 3 MBs. Targeting the transitional progenitor regulators inhibited MYC expression and MB growth. This study provides new insights into the cellular and molecular characteristics of MBs, which may have implications for disease prognosis and potential therapeutic strategies.
Article
Oncology
Stacey Richardson, Rebecca M. Hill, Christopher Kui, Janet C. Lindsey, Yura Grabovksa, Claire Keeling, Louise Pease, Matthew Bashton, Stephen Crosier, Maria Vinci, Nicolas Andre, Dominique Figarella-Branger, Jordan R. Hansford, Maria Lastowska, Krzysztof Zakrzewski, Mette Jorgensen, Jessica C. Pickles, Michael D. Taylor, Stefan M. Pfister, Stephen B. Wharton, Barry Pizer, Antony Michalski, Abhijit Joshi, Thomas S. Jacques, Debbie Hicks, Edward C. Schwalbe, Daniel Williamson, Vijay Ramaswamy, Simon Bailey, Steven C. Clifford
Summary: The study revealed that 40% of putative drivers of medulloblastoma relapse emerged at the time of relapse, showing significant differences between molecular subgroups. Compared to diagnosis, there were more events focusing on targetable pathways at relapse, such as CDK amplifications and USH2A mutations. Many genetic features of medulloblastoma remained stable over time after diagnosis.
Review
Oncology
Leon F. McSwain, Kiran K. Parwani, Shubin W. Shahab, Dolores Hambardzumyan, Tobey J. MacDonald, Jennifer M. Spangle, Anna Marie Kenney
Summary: Medulloblastoma is the most common malignant brain tumor in children. Despite genomic characterization, clinical treatment is still mainly determined by histology and surgical factors rather than molecular profile. DNA damage repair protein inhibitors have the potential for broad impact in all patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biology
Manon Penco-Campillo, Gilles Pages, Sonia Martial
Summary: The therapeutic strategy against medulloblastoma (MB) focuses on accurate diagnosis, post-surgery monitoring, treatment adaptation, and effective therapies for recurrence. Current treatments for MB are severe and result in disabilities. MB recurrence and metastasis are usually fatal, and understanding the key players in this process could help eliminate fatal outcomes. The goal is to reduce treatment intensity and limit disabling effects while offering effective treatments.
Article
Medicine, General & Internal
Somesh Singh, Amrin Israrahmed, Vikrant Verma, Vivek Singh
Summary: This case report describes the rarity of medulloblastoma in an extra-axial location, with a presentation in an 18-year-old boy showing ataxia and headache. It emphasizes the importance of considering medulloblastoma in the differential diagnosis of atypical posterior fossa extra-axial lesions for appropriate management planning.
Article
Oncology
Sergej Telentschak, Daniel Ruess, Stefan Grau, Roland Goldbrunner, Niklas von Spreckelsen, Karolina Jablonska, Harald Treuer, Martin Kocher, Maximilian Ruge
Summary: The study retrospectively analyzed 34 patients treated with CK-hSRS, showing good treatment effectiveness with high local control rates but a 12% complication rate.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Clinical Neurology
Trisha P. Gupte, Chang Li, Lan Jin, Kanat Yalcin, Mark W. Youngblood, Danielle F. Miyagishima, Ketu Mishra-Gorur, Amy Y. Zhao, Joseph Antonios, Anita Huttner, Declan McGuone, Nicholas A. Blondin, Joseph N. Contessa, Yawei Zhang, Robert K. Fulbright, Murat Gunel, Zeynep Erson-Omay, Jennifer Moliterno
Summary: Seizures are relatively common in patients with meningiomas. NF2-mutated tumors are significantly associated with preoperative seizures, but this association appears to be mediated through edema and atypical histology. Patients who undergo radiation and/or have a recurrence are at risk for postoperative seizures.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Nan Qin, Eunice Paisana, Maike Langini, Daniel Picard, Bastian Malzkorn, Carlos Custodia, Rita Cascao, Frauke-Dorothee Meyer, Lena Bluemel, Sarah Goebbels, Kuebra Taban, Jasmin Bartl, Nicole Bechmann, Catleen Conrad, Jan Gravemeyer, Juergen C. Becker, Anja Stefanski, Stephanie Puget, Joao T. Barata, Kai Stuehler, Ute Fischer, Joerg Felsberg, Olivier Ayrault, Guido Reifenberger, Arndt Borkhardt, Graeme Eisenhofer, Claudia C. Faria, Marc Remke
Summary: The study highlights the importance of interclonal cross-talk between MYC-driven and non-MYC-driven cells in medulloblastoma, showing how their interactions influence metastasis, angiogenesis, and tumor progression. Targeting the secretome can effectively suppress this communication between subclones.
Article
Medicine, General & Internal
Yashavanth Kumar, Aanchal Bhatia, Shiv Manik Ajoy, Dev Anand Galagali
Summary: Giant schwannomas in the foot and ankle region are extremely rare. This is a case report of a giant schwannoma arising from the superficial peroneal nerve in the dorsolateral aspect of the foot, which was completely excised and confirmed by histopathology.
Article
Medicine, General & Internal
Xiaojun Zhou, Hao Zhao
Summary: Our study aimed to explore the genes correlated with metastasis in Medulloblastoma (MB) through analyzing differentially expressed genes and pathways. We identified 10 genes, including FAIM2, that were significantly associated with survival of MB patients. FAIM2 expression was decreased in metastatic MB samples, and it harbored mutations, amplifications, and deletions. Pathway analysis showed that FAIM2 high expression group had significantly activated and inhibited pathways compared to FAIM2 low expression group. FAIM2 was tightly correlated with metastasis in MB patients and low expression was associated with poor prognosis.
Article
Biotechnology & Applied Microbiology
Gabriel Arantes dos Santos, Kasit Chatsirisupachai, Roberto A. Avelar, Joao Pedro de Magalhaes
Summary: This study emphasizes the importance of understanding changes in cell identity in cancer and ageing. The findings show that there is a loss of tissue identity with age and a clear pattern in cancer where cells express genes specific to other organs while suppressing the expression of genes from their original tissue. These patterns in cancer are associated with patient survival and are not influenced by age, suggesting their crucial role in carcinogenesis.
Review
Medicine, General & Internal
Pauline H. Lin, George Laliotis
Summary: Breast cancer remains one of the common types of malignancy worldwide, despite the advances in early detection and treatment. Extensive research has led to a better understanding of its drivers and molecular characteristics, allowing for the classification into different subtypes. These subtypes have distinct treatment approaches based on immunohistological markers and transcriptomic signatures.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Aria Fallah, Alexander G. Weil, Kyle Juraschka, George M. Ibrahim, Anthony C. Wang, Louis Crevier, Chi-hong Tseng, Abhaya V. Kulkarni, John Ragheb, Sanjiv Bhatia
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2017)
Article
Oncology
Laureen D. Hachem, Alireza Mansouri, Kyle Juraschka, Shervin Taslimi, Farhad Pirouzmand, Gelareh Zadeh
Article
Endocrinology & Metabolism
James A. Balogun, Eric Monsalves, Kyle Juraschka, Kashif Parvez, Walter Kucharczyk, Ozgur Mete, Fred Gentili, Gelareh Zadeh
ENDOCRINE PATHOLOGY
(2015)
Review
Oncology
Eric Monsalves, Kyle Juraschka, Toru Tateno, Sameer Agnihotri, Sylvia L. Asa, Shereen Ezzat, Gelareh Zadeh
ENDOCRINE-RELATED CANCER
(2014)
Article
Endocrinology & Metabolism
Eric Monsalves, Soroush Larjani, Bruno Loyola Godoy, Kyle Juraschka, Felipe Carvalho, Walter Kucharczyk, Abhaya Kulkarni, Ozgur Mete, Fred Gentili, Shereen Ezzat, Gelareh Zadeh
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2014)
Article
Clinical Neurology
Kyle Juraschka, Osaama H. Khan, Bruno L. Godoy, Eric Monsalves, Alexandra Kilian, Boris Krischek, Aisha Ghare, Allan Vescan, Fred Gentili, Gelareh Zadeh
JOURNAL OF NEUROSURGERY
(2014)
Article
Multidisciplinary Sciences
Maria C. Vladoiu, Ibrahim El-Hamamy, Laura K. Donovan, Hamza Farooq, Borja L. Holgado, Yogi Sundaravadanam, Vijay Ramaswamy, Liam D. Hendrikse, Sachin Kumar, Stephen C. Mack, John J. Y. Lee, Vernon Fong, Kyle Juraschka, David Przelicki, Antony Michealraj, Patryk Skowron, Betty Luu, Hiromichi Suzuki, A. Sorana Morrissy, Florence M. G. Cavalli, Livia Garzia, Craig Daniels, Xiaochong Wu, Maleeha A. Qazi, Sheila K. Singh, Jennifer A. Chan, Marco A. Marra, David Malkin, Peter Dirks, Lawrence Heisler, Trevor Pugh, Karen Ng, Faiyaz Notta, Eric M. Thompson, Claudia L. Kleinman, Alexandra L. Joyner, Nada Jabado, Lincoln Stein, Michael D. Taylor
Article
Multidisciplinary Sciences
Hiromichi Suzuki, Sachin A. Kumar, Shimin Shuai, Ander Diaz-Navarro, Ana Gutierrez-Fernandez, Pasqualino De Antonellis, Florence M. G. Cavalli, Kyle Juraschka, Hamza Farooq, Ichiyo Shibahara, Maria C. Vladoiu, Jiao Zhang, Namal Abeysundara, David Przelicki, Patryk Skowron, Nicole Gauer, Betty Luu, Craig Daniels, Xiaochong Wu, Antoine Forget, Ali Momin, Jun Wang, Weifan Dong, Seung-Ki Kim, Wieslawa A. Grajkowska, Anne Jouvet, Michelle Fevre-Montange, Maria Luisa Garre, Amulya A. Nageswara Rao, Caterina Giannini, Johan M. Kros, Pim J. French, Nada Jabado, Ho-Keung Ng, Wai Sang Poon, Charles G. Eberhart, Ian F. Pollack, James M. Olson, William A. Weiss, Toshihiro Kumabe, Enrique Lopez-Aguilar, Boleslaw Lach, Maura Massimino, Erwin G. Van Meir, Joshua B. Rubin, Rajeev Vibhakar, Lola B. Chambless, Noriyuki Kijima, Almos Klekner, Laszlo Bognar, Jennifer A. Chan, Claudia C. Faria, Jiannis Ragoussis, Stefan M. Pfister, Anna Goldenberg, Robert J. Wechsler-Reya, Swneke D. Bailey, Livia Garzia, A. Sorana Morrissy, Marco A. Marra, Xi Huang, David Malkin, Olivier Ayrault, Vijay Ramaswamy, Xose S. Puente, John A. Calarco, Lincoln Stein, Michael D. Taylor
Article
Biochemistry & Molecular Biology
Kulandaimanuvel Antony Michealraj, Sachin A. Kumar, Leo J. Y. Kim, Florence M. G. Cavalli, David Przelicki, John B. Wojcik, Alberto Delaidelli, Andrea Bajic, Olivier Saulnier, Graham MacLeod, Ravi N. Vellanki, Maria C. Vladoiu, Paul Guilhamon, Winnie Ong, John J. Y. Lee, Yanqing Jiang, Borja L. Holgado, Alex Rasnitsyn, Ahmad A. Malik, Ricky Tsai, Cory M. Richman, Kyle Juraschka, Joonas Haapasalo, Evan Y. Wang, Pasqualino De Antonellis, Hiromichi Suzuki, Hamza Farooq, Polina Balin, Kaitlin Kharas, Randy Van Ommeren, Olga Sirbu, Avesta Rastan, Stacey L. Krumholtz, Michelle Ly, Moloud Ahmadi, Genevieve Deblois, Dilakshan Srikanthan, Betty Luu, James Loukides, Xiaochong Wu, Livia Garzia, Vijay Ramaswamy, Evgeny Kanshin, Maria Sanchez-Osuna, Ibrahim El-Hamamy, Fiona J. Coutinho, Panagiotis Prinos, Sheila Singh, Laura K. Donovan, Craig Daniels, Daniel Schramek, Mike Tyers, Samuel Weiss, Lincoln D. Stein, Mathieu Lupien, Bradly G. Wouters, Benjamin A. Garcia, Cheryl H. Arrowsmith, Poul H. Sorensen, Stephane Angers, Nada Jabado, Peter B. Dirks, Stephen C. Mack, Sameer Agnihotri, Jeremy N. Rich, Michael D. Taylor
Article
Biochemistry & Molecular Biology
Laura K. Donovan, Alberto Delaidelli, Sujith K. Joseph, Kevin Bielamowicz, Kristen Fousek, Borja L. Holgado, Alex Manno, Dilakshan Srikanthan, Ahmed Z. Gad, Randy Van Ommeren, David Przelicki, Cory Richman, Vijay Ramaswamy, Craig Daniels, Jonelle G. Pallota, Tajana Douglas, Alyssa C. M. Joynt, Joonas Haapasalo, Carolina Nor, Maria C. Vladoiu, Claudia M. Kuzan-Fischer, Livia Garzia, Stephen C. Mack, Srinidhi Varadharajan, Matthew L. Baker, Liam Hendrikse, Michelle Ly, Kaitlin Kharas, Polina Balin, Xiaochong Wu, Lei Qin, Ning Huang, Ana Guerreiro Stucklin, A. Sorana Morrissy, Florence M. G. Cavalli, Betty Luu, Raul Suarez, Pasqualino De Antonellis, Antony Michealraj, Avesta Rastan, Meenakshi Hegde, Martin Komosa, Olga Sirbu, Sachin A. Kumar, Zied Abdullaev, Claudia C. Faria, Stephen Yip, Juliette Hukin, Uri Tabori, Cynthia Hawkins, Ken Aldape, Mads Daugaard, John M. Maris, Poul H. Sorensen, Nabil Ahmed, Michael D. Taylor
Review
Clinical Neurology
Claudia Miranda Kuzan-Fischer, Kyle Juraschka, Michael D. Taylor
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2018)