Article
Cell Biology
Song Li, Lihua Luo, Yan He, Ruohan Li, Yangfan Xiang, Zhenjie Xing, Yejian Li, Abdullkhaleg Ali Albashari, Xiangyan Liao, Keke Zhang, Liang Gao, Qingsong Ye
Summary: This study aimed to investigate the protective effects of dental pulp stem cell-derived exosomes (DPSC-Exos) against cerebral ischaemia-reperfusion (I/R) injury and explore the underlying mechanism. DPSC-Exos were found to alleviate brain oedema, cerebral infarction, and neurological impairment in I/R mice, potentially through the inhibition of the HMGB1/TLR4/MyD88/NF-κB pathway. Additionally, DPSC-Exos also showed anti-inflammatory effects by reducing the expression of IL-6, IL-1 beta, and TNF-alpha both in vitro and in vivo.
CELL PROLIFERATION
(2021)
Article
Plant Sciences
Ying Guo, Mingjiang Mao, Qiuying Li, Xiahui Yu, Liping Zhou
Summary: The combination of Ginkgo flavonoids and ginkgolides showed a significant protective effect in reducing cerebral ischaemia-reperfusion injury. This effect may be achieved by activating the PI3K/Akt/Nrf2 signaling pathway and promoting multicomponent interactions in vivo.
Article
Immunology
Qian Xia, Shuai Gao, Tangrui Han, Meng Mao, Gaofeng Zhan, Yonghong Wang, Xing Li
Summary: This study reveals that SIRT5 expression in microglia is increased in the early phase of ischaemic stroke. SIRT5 interacts with and desuccinylates ANXA1, resulting in the inhibition of its membrane recruitment and extracellular secretion, leading to hyperactivation of microglia and excessive inflammatory response, ultimately causing neuronal cell damage.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Hui Liu, Zongbo Zhao, Tao Wu, Qiu Zhang, Fenying Lu, Jie Gu, Tingwang Jiang, Jianzhong Xue
Summary: The study suggests that Spautin-1 may alleviate cerebral ischaemia-reperfusion injury by inhibiting the autophagy/pyroptosis pathway, potentially offering a promising therapeutic approach.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Meng Mao, Qian Xia, Gao-Feng Zhan, Qin-Jun Chu, Xing Li, Hong-Kai Lian
Summary: This study explored the function and mechanism of SENP6 in microglia-induced neuroinflammation after ischemic stroke. The results showed that SENP6 promoted detrimental microglial phenotype polarization by regulating the de-SUMOylation of ANXA1, activating the NF-κB pathway, and enhancing proinflammatory cytokine expression. In addition, inhibition of SENP6 in microglia effectively reduced neuronal damage induced by ischemic stroke. Furthermore, targeted knockdown of SENP6 in microglia/macrophages significantly improved brain ischemic infarct, neurological deficits, and motor and cognitive function in mice.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Martin John Lewis, Igor Khaliulin, Katie Hall, M. Saadeh Suleiman
Summary: This study investigates the effectiveness of cardioprotective intervention in immature hearts and explores the involvement of the mitochondrial permeability transition pore (MPTP). The results demonstrate that immature hearts have a higher innate resistance to ischemia-reperfusion (I/R) injury compared to adult hearts, due to a reduced tendency of MPTP opening following reperfusion. Additionally, simultaneous activation of protein kinase A (PKA) and exchange protein activated by cAMP (Epac) provides cardioprotection that is additive to the innate resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Kayleigh Griffiths, Jordan J. Lee, Michael P. Frenneaux, Martin Feelisch, Melanie Madhani
Summary: Nitric oxide plays a crucial role in protecting the heart from ischemia reperfusion injury through the 'canonical' NO-sGC-cGMP pathway. A new nitrate-nitrite-NO pathway has been discovered to improve endothelial dysfunction, protect the myocardium and reduce infarct size. Nitrite itself also provides multi-faceted protection independent of nitric oxide against various pathophysiologies of IRI.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Medicine, Research & Experimental
Yiwei Huang, Moussa Omorou, Meng Gao, Chenxi Mu, Weijing Xu, Hui Xu
Summary: As an endogenous gas signalling molecule, hydrogen sulfide (H2S) plays a significant role in the cardiovascular and nervous systems. This paper examines the synthesis and metabolism of H2S in the brain, as well as its molecular mechanisms and potential value in cerebral ischaemia-reperfusion injury and other unknown biological functions.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Lei-Lei Ma, Fei-Juan Kong, Zheng Dong, Kai-Yue Xin, Xing-Xu Wang, Ai-Jun Sun, Yun-Zeng Zou, Jun-Bo Ge
Summary: Transient non-ischaemic hypertrophy stimulation through TAC preconditioning can render the heart resistant to subsequent ischaemic injury, reducing myocardial infarct size and apoptosis, and improving cardiac function significantly. TAC preconditioning attenuates I/R-induced autophagy by deacetylating SOD2 via a SIRT3-dependent mechanism, highlighting a novel strategy for cardioprotection against cardiac injury.
CELL PROLIFERATION
(2021)
Review
Cell Biology
Chenxia Hu, Lingfei Zhao, Fen Zhang, Lanjuan Li
Summary: The liver is the only organ with regenerative capacity, but various injury factors can lead to irreversible liver dysfunction. Liver resection and transplantation are effective treatments for liver failure. Melatonin has antioxidant properties and can attenuate liver ischemia/reperfusion injury. Understanding the mechanisms of melatonin's interactions with other cellular processes can improve its potential for treating liver diseases.
CELL PROLIFERATION
(2021)
Article
Plant Sciences
Shengming Huang, Zhanguo Tan, Jirui Cai, Zhiping Wang, Yuejun Tian
Summary: Myrtenol showed protective effects against cerebral ischaemia/reperfusion injury by improving neurological function, reducing brain damage, promoting angiogenesis, and activating the ERK1/2 signalling pathway in MCAO rats. Further research is needed to elucidate its mechanism-of-action in improving ischaemic cerebral infarction.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Neurosciences
Hang Yu, Yuxiang Xie, Mingming Dai, Yuxiang Pan, Chengzhi Xie
Summary: The study demonstrated that vitamin D receptor can prevent cerebral ischemia/reperfusion injury by affecting oxidative stress and interacting with SMAD family member 3, showing a protective effect.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Plant Sciences
Wei Wei, Huihong Li, Yunfei Deng, Xiaoqing Zheng, Yangjie Zhou, Xiehua Xue
Summary: This study aimed to assess whether the neuroprotective effect of AA relied on the efficient transfer of miRNAs via exosomes in the brain. The results showed that AA attenuated inflammation-mediated cerebral ischemia/reperfusion injury by inhibiting astrocyte-derived exosomal miR-200a-3p/141-3p targeting the SIRT1 gene.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Correction
Medicine, Research & Experimental
Cheng-Long Zhang, Tian-Yi Long, Si-Si Bi, Sayed-Ali Sheikh, Fei Li
Summary: The correction to this paper has been published.
LABORATORY INVESTIGATION
(2021)
Article
Cell Biology
Yunhu Yu, Yunpeng Cai, Hang Zhou
Summary: Long non-coding RNA SNHG15 plays an important regulatory role in cerebral ischaemia-reperfusion injury by mediating the miR-153-3p/ATG5 axis to regulate autophagy and prevent damage.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)