Article
Anesthesiology
Karin E. Eriksson, Fredrik Eidhagen, Jan Liska, Anders Franco-Cereceda, Jon O. Lundberg, Eddie Weitzberg
Summary: The preoperative administration of inorganic nitrate did not have an impact on the release of troponin T or other plasma biomarkers of organ injury in cardiac surgery, as seen in this study.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Nutrition & Dietetics
Barbora Piknova, Ji Won Park, Samantha M. Thomas, Khalid J. Tunau-Spencer, Alan N. Schechter
Summary: Nitric oxide (NO) (co)regulates physiological processes in the body and its availability is affected by aging. Aging leads to changes in nitrate and nitrite contents in tissues, with higher nitrate levels and lower nitrite levels in old rats compared to young rats. However, the nitrate reduction pathway is not affected by aging. Further investigation is needed to understand the changes in NO accessibility during aging.
Review
Pharmacology & Pharmacy
Hai-Jian Sun, Zhi-Yuan Wu, Xiao-Wei Nie, Xin-Yu Wang, Jin-Song Bian
Summary: Cardiovascular diseases are common complications of diabetes, with diabetic cardiomyopathy being a major cause of death in diabetes. Research has found that hydrogen sulfide plays a critical role in diabetic cardiomyopathy and has protective effects in conditions such as myocardial infarction and heart failure under diabetic conditions. Studies have identified multiple molecular mechanisms responsible for H2S's protective effects against diabetes-induced cardiac injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Rose I. M. Batista, Renato C. Nogueira, Graziele C. Ferreira, Gustavo H. Oliveira-Paula, Lucas C. Pinheiro, Jose E. Tanus-Santos
Summary: Supplementation with L-arginine has been shown to have beneficial effects in hypertension by increasing nitric oxide formation and enhancing nitrate concentrations, but these effects may be prevented by antiseptic mouthwash. Alteration of the nitrate cycle in the body by mouthwash can impact endothelial dysfunction, antihypertensive effects, and antioxidant effects of L-arginine in hypertensive rats. The findings suggest a new mechanism where antibacterial mouth rinse can affect arterial blood pressure and the development of cardiovascular diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tijana Suboticki, Olivera Mitrovic Ajtic, Dragoslava Djikic, Marijana Kovacic, Juan F. Santibanez, Milica Tosic, Vladan P. Cokic
Summary: In various systems, hydroxyurea has been shown to stimulate the release of nitric oxide or activate nitric oxide synthase. Through inhibiting nitric oxide metabolites, hydroxyurea is able to inhibit the growth of mature erythroid colonies and impact the presence of iNOS immunoreactive CFU-E.
Article
Food Science & Technology
Raul Bescos, Mark L. Rollason, Tanisha S. Davies, Patricia Casas-Agustench
Summary: This study analyzed the content of nitrate (NO3-) and nitrite (NO2-) in commercial and self-made beetroot juices (BJs), finding that the levels of NO3- can vary with different seasons and storage conditions. The self-made BJ showed complete degradation of NO3- after 3 days at 20 degrees C, but this degradation was attenuated when stored at lower temperatures or with the addition of lemon juice. Additionally, self-made BJs had higher concentrations of NO2- and a higher pH compared to commercial BJs.
FOOD SCIENCE & NUTRITION
(2023)
Article
Cell Biology
Florentin-Daniel Staicu, Analuce Canha-Gouveia, Cristina Soriano-Ubeda, Juan Carlos Martinez-Soto, Evdochia Adoamnei, Jorge E. Chavarro, Carmen Matas
Summary: The levels of nitrite and nitrate in follicular fluid were found to be related to the yield of MII oocytes, and nitrate levels showed a suggestive inverse correlation with embryos with high potential of implantation. This suggests that nitrite and nitrate concentrations in follicular fluid may be useful in predicting ovarian response and embryo implantation potential.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Clinical Neurology
Yicong Wang, Weiqi Chen, Jian Zhou, Yongjun Wang, Hao Wang, Yilong Wang
Summary: This review aims to describe the relationship between nitrate metabolism and cerebrovascular disease, providing a basis for further advances in laboratory and clinical medicine.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Gary D. Miller, Beverly A. Nesbit, Daniel B. Kim-Shapiro, Swati Basu, Michael J. Berry
Summary: This study aimed to investigate the acute response of plasma nitrate and nitrite levels in healthy middle- to older-aged adults to beetroot juice alone and in combination with vitamin C or protein. The results showed no significant differences in plasma nitrate and nitrite levels at 1 h and 3 h after co-ingesting beetroot juice with vitamin C or a whey protein supplement compared to beetroot juice alone.
Article
Physiology
Michaela L. Sundqvist, Jon O. Lundberg, Eddie Weitzberg, Mattias Carlstrom
Summary: The study aimed to investigate potential sex differences in renal nitrate handling during low and high dietary nitrate intake. It was hypothesized that renal clearance and excretion of nitrate are higher in men compared to women. Results showed that women had lower urinary nitrate concentration, amount of nitrate excreted, renal nitrate clearance, and fractional excretion of nitrate compared to men.
Article
Biochemistry & Molecular Biology
Samuel J. Gentle, Khandaker A. Ahmed, Nengjun Yi, Casey D. Morrow, Namasivayam Ambalavanan, Charitharth Lal, Rakesh P. Patel
Summary: The study found that nitrate reductase activity in the oral cavity peaked at 29 weeks' post menstrual age, and infants who developed bronchopulmonary dysplasia (BPD) had significantly lower nitrate reductase activity at this time. The oral microbiota and nitrate reductase activity may play a role in the development of BPD in extremely preterm infants.
Review
Biochemistry & Molecular Biology
C. Dias, C. F. Lourenco, J. Laranjinha, A. Ledo
Summary: Nitrite can serve as an alternative source of nitric oxide production, independent of nitric oxide synthase activity, particularly in conditions of low oxygen availability. Increasing nitrite concentration through diet may provide a therapeutic intervention for brain ischemia. Nitrite has been found to modulate mitochondrial function and decrease oxidative burst in in vitro and in vivo models of ischemia/reperfusion.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Zahra Bahadoran, Parvin Mirmiran, Khosrow Kashfi, Asghar Ghasemi
Summary: The lack of beneficial metabolic effects of inorganic NO3- in patients with T2DM may be attributed to species differences in AA metabolism and abnormal AA metabolism in patients with T2DM. Supplementation of AA may be needed for T2DM patients to attain the benefits of inorganic NO3- therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Stephanie M. Mutchler, Mahpara Hasan, Donald E. Kohan, Thomas R. Kleyman, Roderick J. Tan
Summary: Our study demonstrates that deletion of the gamma subunit of ENaC, while allowing for greater activation of eNOS, is not sufficient to prevent IRI. This suggests that the protective effects of alpha subunit deletion may be due, in part, to other mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Lauren K. Park, Andrew R. Coggan, Linda R. Peterson
Summary: Despite advances, heart failure with reduced ejection fraction (HFrEF) remains a deadly and disabling disease. Exercise capacity is closely linked to survival in HFrEF patients, and impaired nitric oxide (NO) bioavailability plays a key role in skeletal muscle pathology. Ingestion of inorganic nitrate has shown potential in improving exercise performance for HFrEF patients.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Elodie Lespagnol, Semah Tagougui, Bernadette O. Fernandez, Farid Zerimech, Regis Matran, Patrice Maboudou, Serge Berthoin, Amandine Descat, Isabelle Kim, Mehdi Pawlak-Chaouch, Julien Boissiere, Eric Boulanger, Martin Feelisch, Pierre Fontaine, Elsa Heyman
Summary: This study found that individuals with type 1 diabetes exhibit compromised endothelial function during physical exercise, possibly due to alterations in nitric oxide formation or metabolism. Despite lower availability of NO-related substrates, oxidative stress did not worsen, and differences in habitual physical activity levels between participants did not impact the results.
Article
Anesthesiology
Alexander H. Oldman, Daniel S. Martin, Martin Feelisch, Michael P. W. Grocott, Andrew F. Cumpstey
Summary: Higher FiO(2) may be associated with elevated oxidative stress during surgery, but limited studies have specifically reported biomarkers of oxidation. Further research in this area is urgently needed due to the current clinical controversy concerning perioperative oxygen therapy.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Biochemistry & Molecular Biology
Andrew F. Cumpstey, Anna D. Clark, Jerome Santolini, Alan A. Jackson, Martin Feelisch
Summary: COVID-19 as a redox disease has far-reaching effects on the human body, affecting vulnerable interconnected systems with multiorgan/multilevel interdependencies. The interaction between host/viral glycan plays a crucial role in SARS-CoV-2's cellular access and evasion of antiviral defenses. Understanding the redox landscape may offer new therapeutic approaches to tackle COVID-19 and Long-COVID.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Cell Biology
Kyle T. Mincham, Kunjal Panchal, Prue H. Hart, Robyn M. Lucas, Martin Feelisch, Richard B. Weller, Vance B. Matthews, Deborah H. Strickland, Shelley Gorman
Summary: Eating a high-fat diet can impact the proportions of HSPCs and cDCs in BAT and bone marrow; compared to a low-fat diet, a high-fat diet significantly reduces myeloid progenitors in iBAT.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Respiratory System
Matthew J. Pavitt, Adam Lewis, Sara C. Buttery, Bernadette O. Fernandez, Monika Mikus-Lelinska, Winston A. S. Banya, Martin Feelisch, Michael Polkey, Nicholas S. Hopkinson
Summary: The study found that acute dietary nitrate supplementation significantly improved exercise performance and endothelial function in COPD patients requiring supplemental oxygen.
Article
Biochemistry & Molecular Biology
Hanno Maassen, M. Yusof Said, Anne-Roos S. Frenay, Anne Koning, Adrian Post, Ineke J. Riphagen, M. Rebecca Heiner-Fokkema, Kathrin Drabert, Bernadette O. Fernandez, Reinold O. B. Gans, Else van den Berg, Gerjan Navis, Dimitrios Tsikas, Martin Feelisch, Stephan J. L. Bakker, Harry van Goor
Summary: Impaired endogenous nitric oxide (NO) production may contribute to graft failure and premature mortality in kidney transplant recipients. This study found that lower urinary excretion of NOx was associated with a higher risk of all-cause and cardiovascular mortality in kidney transplant recipients.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Physiology
Philip J. Hennis, Andrew F. Cumpstey, Alasdair F. O'Doherty, Bernadette O. Fernandez, Edward T. Gilbert-Kawai, Kay Mitchell, Helen Moyses, Alexandra Cobb, Paula Meale, Helmut Poehnl, Monty G. Mythen, Michael P. W. Grocott, Denny Z. H. Levett, Daniel S. Martin, Martin Feelisch, Xtreme Alps Res Grp
Summary: This study investigated the effects of nitrate supplementation on exercise physiology during high altitude exposure. The results showed that exercise at high altitude reduced nitrate and nitrite levels in the blood, but nitrate supplementation reversed this phenomenon. However, it did not improve exercise efficiency. Interestingly, nitrate supplementation also decreased V?O(2)peak.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Peripheral Vascular Disease
Richard B. Weller, Iain M. Macintyre, Vanessa Melville, Michael Farrugia, Martin Feelisch, David J. Webb
Summary: Latitude and season are correlated with ultraviolet radiation exposure and blood pressure. This study tested the effectiveness of low-dose daily UVA phototherapy for mild hypertension and found that it did not effectively control blood pressure but caused a transient fall.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Biochemistry & Molecular Biology
Renato C. Nogueira, Magdalena Minnion, Anna D. Clark, Alex Dyson, Jose E. Tanus-Santos, Martin Feelisch
Summary: Nitrite concentrations in blood play a crucial role in assessing intracellular nitric oxide (NO) activity and endothelial function. However, using nitrosylhemoglobin (HbNO) as an early marker of COVID-19 patient risk may be premature.
Article
Biochemistry & Molecular Biology
Kayleigh Griffiths, Tomoaki Ida, Masanobu Morita, Reece J. Lamb, Jordan J. Lee, Michael P. Frenneaux, Jon M. Fukuto, Takaaki Akaike, Martin Feelisch, Melanie Madhani
Summary: Earlier studies have shown that CysSSH, a sulfur-containing compound, has antioxidant and oxidant properties and can mitigate oxidative stress. However, its role in myocardial IRI was not understood. This study investigated the production and consumption of CysSSH in the heart under normoxic and hypoxic conditions and found that exogenous administration of Cys-SSS-Cys can rescue the heart from injury and improve cardiac function.
Article
Biochemistry & Molecular Biology
Arno R. Bourgonje, Damian Kloska, Anna Grochot-Przeczek, Martin Feelisch, Antonio Cuadrado, Harry van Goor
Summary: Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are closely associated with inflammation and overproduction of reactive oxygen species (ROS). The variability in disease activity and response to therapy poses challenges to diagnosis and patient care. The use of redox metabolomics approaches and integration of clinical-omics can help identify disrupted redox signaling pathways and develop personalized redox medicine approaches for IBD treatment.
Article
Biochemistry & Molecular Biology
Amanda M. L. Rhodes, Sehrish Ali, Magdalena Minnion, Ling H. Lee, Brijil M. Joseph, Judwin Ndzo, Nicholas M. P. Clarke, Martin Feelisch, Alexander Aarvold
Summary: This study aimed to explore specific biochemical pathways in skeletal development for potential involvement in the aetiology of developmental dysplasia of the hip (DDH). Analysis of urine samples from infants revealed significant differences in the concentrations of certain chemicals, particularly higher levels of sulphate, in DDH patients compared to controls. This investigation highlights the potential of urine metabolomics and the importance of normalisation for hydration status.
Letter
Infectious Diseases
Martin Feelisch, Anna D. Clark, Andrew F. Cumpstey, Jerome Santolini, Alan A. Jackson
JOURNAL OF INFECTION
(2023)
Review
Biology
Martin Feelisch, Miriam M. Cortese-Krott, Jerome Santolini, Stephen A. Wootton, Alan A. Jackson
Summary: Understanding biological stress responses is crucial for maintaining health and managing diseases. Integrating stress responses across different levels of organization provides insights into the nature and inter-relationship of complex systems. The versatile chemistry of sulfur plays a central role in stress responses.