PPARγ neddylation essential for adipogenesis is a potential target for treating obesity

Pevonedistat (MLN4924), a First-in-Class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study

(2015) Ronan T. Swords et al.   BRITISH JOURNAL OF HAEMATOLOGY

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation

(2012) P Hallenborg et al.   CELL DEATH AND DIFFERENTIATION

Do we need anti-obesity drugs?

(2012) Vojtěch Hainer et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Covalent NEDD8 Conjugation Increases RCAN1 Protein Stability and Potentiates Its Inhibitory Action on Calcineurin

(2012) Eun Hye Noh et al.   PLoS One

Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation

(2011) Nieves Embade et al.   HEPATOLOGY

Stereoselective Synthesis of MLN4924, an Inhibitor of NEDD8-Activating Enzyme

(2011) Hyuk Woo Lee et al.   JOURNAL OF ORGANIC CHEMISTRY

Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program

(2011) Malcolm A. Smith et al.   PEDIATRIC BLOOD & CANCER

SUMO modification selectively regulates transcriptional activity of peroxisome-proliferator-activated receptor γ in C2C12 myotubes

(2010) Sung Soo Chung et al.   BIOCHEMICAL JOURNAL

Propagation of adipogenic signals through an epigenomic transition state

(2010) D. J. Steger et al.   GENES & DEVELOPMENT

Hypoxia-inducible Factor α Subunit Stabilization by NEDD8 Conjugation Is Reactive Oxygen Species-dependent

(2010) Ji-Hye Ryu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

PPAR-γ AF-2 Domain Functions as a Component of a Ubiquitin-dependent Degradation Signal

(2009) Gail E. Kilroy et al.   Obesity

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Function and regulation of protein neddylation. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Gwénaël Rabut et al.   EMBO REPORTS

Dynamics of fat cell turnover in humans

(2008) Kirsty L. Spalding et al.   NATURE

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

(2008) Vikas Chandra et al.   NATURE