Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45)

The highly recurrent PP2A Aα-subunit mutation P179R alters protein structure and impairs PP2A enzyme function to promote endometrial tumorigenesis

(2019) Sarah E Taylor et al.   CANCER RESEARCH

Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer

(2018) Kimberly McClinch et al.   CANCER RESEARCH

Therapeutic targeting of PP2A

(2018) Caitlin M. O’Connor et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ATR/CHK1 inhibitors and cancer therapy

(2018) Zhaojun Qiu et al.   RADIOTHERAPY AND ONCOLOGY

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

(2018) Otto Kauko et al.   Science Translational Medicine

Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma

(2018) Brittany L. Allen-Petersen et al.   CANCER RESEARCH

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

(2017) Jaya Sangodkar et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphoproteomics Profiling of Nonsmall Cell Lung Cancer Cells Treated with a Novel Phosphatase Activator

(2017) Danica D. Wiredja et al.   PROTEOMICS

Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth

(2016) Dorien Haesen et al.   CANCER RESEARCH

PP2A as a master regulator of the cell cycle

(2016) Nathan Wlodarchak et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The ORFeome Collaboration: a genome-scale human ORF-clone resource

(2016)   NATURE METHODS

All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase

(2015) Jaya Sangodkar et al.   FEBS Journal

Exploiting replicative stress to treat cancer

(2015) Matthias Dobbelstein et al.   NATURE REVIEWS DRUG DISCOVERY

The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1

(2015) Tai-Yu Lai et al.   Oncotarget

Protein Phosphatase 2A and Cdc7 Kinase Regulate the DNA Unwinding Element-binding Protein in Replication Initiation

(2014) Yanzhe Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

(2014) Alejandro Gutierrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Replisome components—Post-translational modifications and their effects

(2014) Juergen Zech et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer

(2013) Parthasarathy Seshacharyulu et al.   CANCER LETTERS

Impediments to replication fork movement: stabilisation, reactivation and genome instability

(2013) Sarah Lambert et al.   CHROMOSOMA

Replication-Fork Dynamics

(2013) K. E. Duderstadt et al.   Cold Spring Harbor Perspectives in Biology

Response to DNA damage: why do we need to focus on protein phosphatases?

(2013) Midori Shimada et al.   Frontiers in Oncology

Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response

(2012) Jaya Sangodkar et al.   JOURNAL OF CLINICAL INVESTIGATION

The B56γ3 Regulatory Subunit of Protein Phosphatase 2A (PP2A) Regulates S Phase-specific Nuclear Accumulation of PP2A and the G1to S Transition

(2010) Ting-Yuan Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Cdc45 in the cell cycle and after DNA damage

(2009) Ronan Broderick et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The S-phase checkpoint: targeting the replication fork

(2009) Mónica Segurado et al.   BIOLOGY OF THE CELL

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Protein Phosphatase 2A-Dependent Dephosphorylation of Replication Protein A Is Required for the Repair of DNA Breaks Induced by Replication Stress

(2009) J. Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens

(2009) Jingwei Cheng et al.   SEMINARS IN CANCER BIOLOGY

Protein phosphatase 2A regulatory subunits and cancer

(2008) Pieter J.A. Eichhorn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

SV40 small T antigen and PP2A phosphatase in cell transformation

(2008) Anna A. Sablina et al.   CANCER AND METASTASIS REVIEWS