Hyperinsulinemia or Insulin Resistance: What Impacts the Progression of Alzheimer’s Disease?

Molecular and cellular bases of diabetes: Focus on type 2 diabetes mouse model-TallyHo

(2019) Kavya Tamarai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Intranasal insulin in Alzheimer's disease: Food for thought

(2018) Colin D. Chapman et al.   NEUROPHARMACOLOGY

Hyperinsulinemia is associated with increasing insulin secretion but not with decreasing insulin clearance in an age-related metabolic dysfunction mice model

(2018) Mirian A. Kurauti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Twenty-five years of research about adipogenic adenoviruses: A systematic review

(2018) Md Akheruzzaman et al.   Obesity Reviews

E4orf1: A protein for enhancing glucose uptake despite impaired proximal insulin signaling

(2018) Anuradha A. Shastri et al.   PLoS One

Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial

(2017) Suzanne Craft et al.   JOURNAL OF ALZHEIMERS DISEASE

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

A Multi-Center Randomized Proof-of-Concept Clinical Trial Applying [18F]FDG-PET for Evaluation of Metabolic Therapy with Rosiglitazone XR in Mild to Moderate Alzheimer's Disease

(2017) Sofia Tzimopoulou et al.   JOURNAL OF ALZHEIMERS DISEASE

An adenovirus-derived protein: A novel candidate for anti-diabetic drug development

(2016) Vijay Hegde et al.   BIOCHIMIE

Hepatic Expression of Adenovirus 36 E4ORF1 Improves Glycemic Control and Promotes Glucose Metabolism Through AKT Activation

(2016) Travis B. McMurphy et al.   DIABETES

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

(2016) Erica Barini et al.   Molecular Neurodegeneration

E4orf1 Enhances Glucose Uptake Independent of Proximal Insulin Signaling

(2016) Ha-Na Na et al.   PLoS One

Recent global trends in the prevalence and incidence of dementia, and survival with dementia

(2016) Martin Prince et al.   Alzheimers Research & Therapy

Type 2 Diabetes and the Aging Pancreatic Beta Cell

(2016) Uma Gunasekaran et al.   Aging-US

Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect

(2015) Pasquale Picone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

E4orf1 induction in adipose tissue promotes insulin-independent signaling in the adipocyte

(2015) Christine M. Kusminski et al.   Molecular Metabolism

Type 2 Diabetes as a Risk Factor for Alzheimer's Disease: The Confounders, Interactions, and Neuropathology Associated With This Relationship

(2013) N. T. Vagelatos et al.   EPIDEMIOLOGIC REVIEWS

Doxycycline-Regulated 3T3-L1 Preadipocyte Cell Line with Inducible, Stable Expression of Adenoviral E4orf1 Gene: A Cell Model to Study Insulin-Independent Glucose Disposal

(2013) Rashmi Krishnapuram et al.   PLoS One

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Basal state hyperinsulinemia in healthy normoglycemic adults heralds dysglycemia after more than two decades of follow up

(2012) R. Dankner et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

The Role of Glucose Transporters in Brain Disease: Diabetes and Alzheimer's Disease

(2012) Kaushik Shah et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insulin receptor-independent upregulation of cellular glucose uptake

(2012) R Krishnapuram et al.   INTERNATIONAL JOURNAL OF OBESITY

Insulin sparing action of Adenovirus 36 and its E4orf1 protein

(2012) Nikhil V. Dhurandhar   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Overlapped Metabolic and Therapeutic Links between Alzheimer and Diabetes

(2012) Waqar Ahmad   MOLECULAR NEUROBIOLOGY

E4orf1 Improves Lipid and Glucose Metabolism in Hepatocytes: A Template to Improve Steatosis & Hyperglycemia

(2012) Emily J. Dhurandhar et al.   PLoS One

Cognitive impairment in diabetic patients: Can diabetic control prevent cognitive decline?

(2012) Takahiko Kawamura et al.   Journal of Diabetes Investigation

Template to improve glycemic control without reducing adiposity or dietary fat

(2011) R. Krishnapuram et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Brain aging, Alzheimer's disease, and mitochondria

(2011) Russell H. Swerdlow   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Rosiglitazone Does Not Improve Cognition or Global Function when Used as Adjunctive Therapy to AChE Inhibitors in Mild-to-Moderate Alzheimers Disease: Two Phase 3 Studies

(2011) C. Harrington et al.   Current Alzheimer Research

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

E4orf1: A Novel Ligand That Improves Glucose Disposal in Cell Culture

(2011) Emily J. Dhurandhar et al.   PLoS One

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

(2010) Michael Gold et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic β-Cell Leptin Signaling

(2010) Sarah L. Gray et al.   ENDOCRINOLOGY

Diabetes, Alzheimer disease, and vascular dementia: A population-based neuropathologic study

(2010) S. Ahtiluoto et al.   NEUROLOGY

Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

(2010) Luis Escribano et al.   NEUROPSYCHOPHARMACOLOGY

Molecular Mechanism of Insulin Resistance in Obesity and Type 2 Diabetes

(2010) Kangduk Choi et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

(2009) Johan Rung et al.   NATURE GENETICS

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced Risk for Alzheimer Disease in Persons With Type 2 Diabetes and APOE ε4

(2008) Fumiko Irie et al.   ARCHIVES OF NEUROLOGY

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

(2008) Wei-Qin Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Insulin Resistance and Hyperinsulinemia: Is hyperinsulinemia the cart or the horse?

(2008) M. H. Shanik et al.   DIABETES CARE

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin

(2008) C.G. Jolivalt et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cognition and diabetes: a lifespan perspective

(2008) Geert Jan Biessels et al.   LANCET NEUROLOGY

Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology

(2008) M. S. Beeri et al.   NEUROLOGY

Impaired insulin secretion increases the risk of Alzheimer disease

(2008) E. Ronnemaa et al.   NEUROLOGY

PPARγ agonists as therapeutics for the treatment of Alzheimer’s disease

(2008) Gary Landreth et al.   Neurotherapeutics