Pharmacological Targeting of GLUT1 to Control Autoreactive T Cell Responses

Low-Carb and Ketogenic Diets in Type 1 and Type 2 Diabetes

(2019) Bolla et al.   Nutrients

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

(2019) Kevan C. Herold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Detection and Characterization of CD8+Autoreactive Memory Stem T Cells in Patients With Type 1 Diabetes

(2018) Debora Vignali et al.   DIABETES

Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1

(2018) Maia Kavanagh Williamson et al.   Viruses-Basel

Peptide Immunotherapy for Type 1 Diabetes—Clinical Advances

(2018) Emma L. Smith et al.   Frontiers in Immunology

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

(2018) Niamh C. Williams et al.   Frontiers in Immunology

Immune Mechanisms and Pathways Targeted in Type 1 Diabetes

(2018) Laura M. Jacobsen et al.   Current Diabetes Reports

Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis

(2018) Georges Abboud et al.   Frontiers in Immunology

Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876

(2018) Yibao Ma et al.   Cancers

Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation

(2017) Ian A. Bettencourt et al.   JOURNAL OF IMMUNOLOGY

Oxidative phosphorylation: regulation and role in cellular and tissue metabolism

(2017) David F. Wilson   JOURNAL OF PHYSIOLOGY-LONDON

Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876

(2016) Holger Siebeneicher et al.   ChemMedChem

Characterization of Diabetogenic CD8+ T Cells

(2016) Justin W. Garyu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenylm-Hydroxybenzoate) Inhibits GLUT1-mediated Sugar Transport by Binding Reversibly at the Exofacial Sugar Binding Site

(2016) Ogooluwa A. Ojelabi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia

(2016) Peter J. Siska et al.   JOURNAL OF IMMUNOLOGY

Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice

(2016) Yafei Sun et al.   JOURNAL OF NEUROIMMUNOLOGY

Emerging concepts of T cell metabolism as a target of immunotherapy

(2016) Chih-Hao Chang et al.   NATURE IMMUNOLOGY

Clinical pancreatic islet transplantation

(2016) A. M. James Shapiro et al.   Nature Reviews Endocrinology

Anticancer agents interacting with membrane glucose transporters

(2016) C. Granchi et al.   MedChemComm

Long-Term Follow-Up of the Edmonton Protocol of Islet Transplantation in the United States

(2015) D. C. Brennan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes

(2014) Drew J. Adams et al.   ACS Chemical Biology

2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy

(2014) Dongsheng Zhang et al.   CANCER LETTERS

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

GLUT1 deficiency syndrome into adulthood: a follow-up study

(2014) W. G. Leen et al.   JOURNAL OF NEUROLOGY

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

Homeostatic T Cell Proliferation after Islet Transplantation

(2013) Paolo Monti et al.   Clinical & Developmental Immunology

Progress in immune-based therapies for type 1 diabetes

(2013) M. von Herrath et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Phenotypic Spectrum of Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)

(2013) Toni S. Pearson et al.   Current Neurology and Neuroscience Reports

Activation of Islet Autoreactive Naive T Cells in Infants Is Influenced by Homeostatic Mechanisms and Antigen-Presenting Capacity

(2013) A.-K. Heninger et al.   DIABETES

Death and Dysfunction of Transplanted  -Cells: Lessons Learned From Type 2 Diabetes?

(2013) K. J. Potter et al.   DIABETES

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

(2013) Madhusudhanan Sukumar et al.   JOURNAL OF CLINICAL INVESTIGATION

The current state of pancreas transplantation

(2013) Rainer W. G. Gruessner et al.   Nature Reviews Endocrinology

Expression and Regulation of Nampt in Human Islets

(2013) Karen Kover et al.   PLoS One

GLUT1 deficiency syndrome 2013: Current state of the art

(2013) Valentina De Giorgis et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

T Cell Autoreactivity in the Transplant Milieu

(2012) J. Matthis et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

(2012) Luis E. Raez et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Alloantibody and Autoantibody Monitoring Predicts Islet Transplantation Outcome in Human Type 1 Diabetes

(2012) L. Piemonti et al.   DIABETES

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial

(2011) Diane K Wherrett et al.   LANCET

Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

(2011) D. A. Chan et al.   Science Translational Medicine

Interleukin-7 Receptor Signaling Network: An Integrated Systems Perspective

(2010) Megan J Palmer et al.   Cellular & Molecular Immunology

Glucose transporters in the 21st Century

(2009) Bernard Thorens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Disengaging the IL-2 Receptor with Daclizumab Enhances IL-7-Mediated Proliferation of CD4+and CD8+T Cells

(2009) P. Monti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

(2008) Candace M. Cham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells

(2008) Paolo Monti et al.   JOURNAL OF CLINICAL INVESTIGATION