Microglia and sexual differentiation of the developing brain: A focus on extrinsic factors

Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play

(2019) Jonathan W. VanRyzin et al.   NEURON

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration

(2019) Emily G. O’Koren et al.   IMMUNITY

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

(2018) Morgane Sonia Thion et al.   CELL

Sexual dimorphism of microglia and synapses during mouse postnatal development

(2018) Laetitia Weinhard et al.   Developmental Neurobiology

Microglia: Driving critical periods and sexual differentiation of the brain

(2018) Jonathan W. VanRyzin et al.   Developmental Neurobiology

Cerebellar microglia are dynamically unique and survey Purkinje neurons in vivo

(2018) Rianne D. Stowell et al.   Developmental Neurobiology

Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner

(2018) Moumita Datta et al.   IMMUNITY

Epigenetic regulation of brain region-specific microglia clearance activity

(2018) Pinar Ayata et al.   NATURE NEUROSCIENCE

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

(2018) F. Chris Bennett et al.   NEURON

Fast, furious and enduring: Sensitive versus critical periods in sexual differentiation of the brain

(2018) Margaret M. McCarthy et al.   PHYSIOLOGY & BEHAVIOR

Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development

(2018) Ilia D. Vainchtein et al.   SCIENCE

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

(2018) Laetitia Weinhard et al.   Nature Communications

Sex-Specific Features of Microglia from Adult Mice

(2018) Alessandro Villa et al.   Cell Reports

Mast Cells in the Developing Brain Determine Adult Sexual Behavior

(2018) Kathryn M. Lenz et al.   JOURNAL OF NEUROSCIENCE

Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats

(2018) Ashley M. Kopec et al.   Nature Communications

Transcriptional and Translational Differences of Microglia from Male and Female Brains

(2018) Dilansu Guneykaya et al.   Cell Reports

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

(2018) Chotima Böttcher et al.   NATURE NEUROSCIENCE

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

Age-specific function of α5β1 integrin in microglial migration during early colonization of the developing mouse cortex

(2017) Sophie Marie-Thérèse Smolders et al.   GLIA

Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity

(2017) Richa Hanamsagar et al.   GLIA

Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain

(2017) Margaret M. McCarthy et al.   NATURE REVIEWS NEUROSCIENCE

Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia

(2017) Lindsay M. De Biase et al.   NEURON

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

Activation of neonatal microglia can be influenced by other neural cells

(2017) Alexandra Turano et al.   NEUROSCIENCE LETTERS

Developmental changes in microglial mobilization are independent of apoptosis in the neonatal mouse hippocampus

(2016) Ukpong B. Eyo et al.   BRAIN BEHAVIOR AND IMMUNITY

Early life stress perturbs the maturation of microglia in the developing hippocampus

(2016) Jean-Christophe Delpech et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine

(2016) Jin Xu et al.   DEVELOPMENTAL CELL

Estrogens, Neuroinflammation, and Neurodegeneration

(2016) Alessandro Villa et al.   ENDOCRINE REVIEWS

A general theory of sexual differentiation

(2016) Arthur P. Arnold   JOURNAL OF NEUROSCIENCE RESEARCH

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

(2016) Ido Amit et al.   NATURE IMMUNOLOGY

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Beyond sex differences: new approaches for thinking about variation in brain structure and function

(2016) Daphna Joel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Microglia contact induces synapse formation in developing somatosensory cortex

(2016) Akiko Miyamoto et al.   Nature Communications

Developmental Apoptosis Mediates Entry and Positioning of Microglia in the Zebrafish Brain

(2016) Alessandra Maria Casano et al.   Cell Reports

Microglial numbers attain adult levels after undergoing a rapid decrease in cell number in the third postnatal week

(2015) Maria Nikodemova et al.   JOURNAL OF NEUROIMMUNOLOGY

Structure of a Biologically Active Estrogen Receptor-Coactivator Complex on DNA

(2015) Ping Yi et al.   MOLECULAR CELL

Brain feminization requires active repression of masculinization via DNA methylation

(2015) Bridget M Nugent et al.   NATURE NEUROSCIENCE

Brain region-specific gene expression profiles in freshly isolated rat microglia

(2015) Karlijn J. Doorn et al.   Frontiers in Cellular Neuroscience

Microglia shape corpus callosum axon tract fasciculation: functional impact of prenatal inflammation

(2014) Lorena Pont-Lezica et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone

(2014) Y. Shigemoto-Mogami et al.   JOURNAL OF NEUROSCIENCE

Activation of Neuronal NMDA Receptors Triggers Transient ATP-Mediated Microglial Process Outgrowth

(2014) L. Dissing-Olesen et al.   JOURNAL OF NEUROSCIENCE

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia

(2014) Fargol Mazaheri et al.   Nature Communications

Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex

(2014) Benedetta Arnò et al.   Nature Communications

Microglia Modulate Wiring of the Embryonic Forebrain

(2014) Paola Squarzoni et al.   Cell Reports

Prenatal air pollution exposure induces sexually dimorphic fetal programming of metabolic and neuroinflammatory outcomes in adult offspring

(2013) Jessica L. Bolton et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease

(2013) L. K. Case et al.   GENOME RESEARCH

The NADPH oxidase Nox2 regulates VEGFR1/CSF-1R-mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex

(2013) Aurélia Lelli et al.   GLIA

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

Microglia Are Essential to Masculinization of Brain and Behavior

(2013) K. M. Lenz et al.   JOURNAL OF NEUROSCIENCE

Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice

(2013) Jessica M. Crain et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Proteomic Analysis of Coregulators Bound to ERα on DNA and Nucleosomes Reveals Coregulator Dynamics

(2013) Charles E. Foulds et al.   MOLECULAR CELL

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Microglia Actively Regulate the Number of Functional Synapses

(2013) Kyungmin Ji et al.   PLoS One

Neuronal Synapse Formation Induced by Microglia and Interleukin 10

(2013) So-Hee Lim et al.   PLoS One

Prenatal stress increases the expression of proinflammatory cytokines and exacerbates the inflammatory response to LPS in the hippocampal formation of adult male mice

(2012) Yolanda Diz-Chaves et al.   BRAIN BEHAVIOR AND IMMUNITY

Mammalian sex determination—insights from humans and mice

(2012) Stefanie Eggers et al.   CHROMOSOME RESEARCH

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

(2012) Ying Li et al.   DEVELOPMENTAL CELL

Complex invasion pattern of the cerebral cortex bymicroglial cells during development of the mouse embryo

(2012) Nina Swinnen et al.   GLIA

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice

(2012) Yolanda Diz-Chaves et al.   Journal of Neuroinflammation

Deficiency of the Microglial Receptor CX3CR1 Impairs Postnatal Functional Development of Thalamocortical Synapses in the Barrel Cortex

(2012) M. Hoshiko et al.   JOURNAL OF NEUROSCIENCE

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Neural progenitor cells regulate microglia functions and activity

(2012) Kira I Mosher et al.   NATURE NEUROSCIENCE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Involvement of postnatal apoptosis on sex difference in number of cells generated during late fetal period in the sexually dimorphic nucleus of the preoptic area in rats

(2012) Yukinori Kato et al.   NEUROSCIENCE LETTERS

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Early-Life Experience Decreases Drug-Induced Reinstatement of Morphine CPP in Adulthood via Microglial-Specific Epigenetic Programming of Anti-Inflammatory IL-10 Expression

(2011) J. M. Schwarz et al.   JOURNAL OF NEUROSCIENCE

CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity

(2011) J. T. Rogers et al.   JOURNAL OF NEUROSCIENCE

Reframing sexual differentiation of the brain

(2011) Margaret M McCarthy et al.   NATURE NEUROSCIENCE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Microglial Morphology and Dynamic Behavior Is Regulated by Ionotropic Glutamatergic and GABAergic Neurotransmission

(2011) Aurora M. Fontainhas et al.   PLoS One

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Developmental Time Course of Estradiol, Testosterone, and Dihydrotestosterone Levels in Discrete Regions of Male and Female Rat Brain

(2010) Anne T. M. Konkle et al.   ENDOCRINOLOGY

Enduring consequences of maternal obesity for brain inflammation and behavior of offspring

(2010) Staci D. Bilbo et al.   FASEB JOURNAL

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

(2010) Suwen Wei et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior

(2010) D. L. Krebs-Kraft et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

A developmental sex difference in hippocampal neurogenesis is mediated by endogenous oestradiol

(2010) J Michael Bowers et al.   Biology of Sex Differences

Prenatal stress alters microglial development and distribution in postnatal rat brain

(2009) Beatriz Gómez-González et al.   ACTA NEUROPATHOLOGICA

Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain

(2009) Sondra T. Bland et al.   BRAIN BEHAVIOR AND IMMUNITY

Estrogen Masculinizes Neural Pathways and Sex-Specific Behaviors

(2009) Melody V. Wu et al.   CELL

Prostaglandin E2-Induced Masculinization of Brain and Behavior Requires Protein Kinase A, AMPA/Kainate, and Metabotropic Glutamate Receptor Signaling

(2009) C. L. Wright et al.   JOURNAL OF NEUROSCIENCE

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Impact of sex and hormones on new cells in the developing rat hippocampus: a novel source of sex dimorphism?

(2008) Jian-Min Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Steroid hormone receptor expression and function in microglia

(2008) Amanda Sierra et al.   GLIA

The role of androgen receptors in the masculinization of brain and behavior: What we've learned from the testicular feminization mutation

(2008) Damian G. Zuloaga et al.   HORMONES AND BEHAVIOR

Sex-Specific Differences in Expression of Histone Demethylases Utx and Uty in Mouse Brain and Neurons

(2008) J. Xu et al.   JOURNAL OF NEUROSCIENCE

Developmental Neuronal Death in Hippocampus Requires the Microglial CD11b Integrin and DAP12 Immunoreceptor

(2008) S. Wakselman et al.   JOURNAL OF NEUROSCIENCE

Sex-Specific Expression of the X-Linked Histone Demethylase Gene Jarid1c in Brain

(2008) Jun Xu et al.   PLoS One