Article
Gastroenterology & Hepatology
Saravanan Subramanian, Hua Geng, Chao Du, Pauline M. Chou, Heng-Fu Bu, Xiao Wang, Suchitra Swaminathan, Stephanie C. Tan, Jason M. Ridlon, Isabelle G. De Plaen, Xiao-Di Tan
Summary: This study investigated the impact of feeding modes on the gut microbiome, physiological inflammation, and susceptibility to intestinal injury in neonatal mice. The results showed that formula feeding altered the gut microbiome, increased inflammatory activity, and predisposed the mice to intestinal injury. These findings contribute to a better understanding of gastrointestinal diseases in infants.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Immunology
Xiao-Lin Yan, Xiao-Chen Liu, Yu-Ni Zhang, Ting-Ting Du, Qing Ai, Xiong Gao, Jing-Li Yang, Lei Bao, Lu-Quan Li
Summary: This study found that succinate plays an important role in the pathogenesis and severity of necrotizing enterocolitis, and the activation of the HIF-1α signaling pathway may lead to disease progression.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Weiming Wang, Meng Geng, Caixia Zhu, Lei Huang, Yue Zhang, Tengxun Zhang, Chongjie Zhao, Tongcun Zhang, Xinjun Du, Nan Wang
Summary: The study revealed that the novel probiotic Ligilactobacillus salivarius YL20 could protect against C. sakazakii-induced intestinal injury by promoting epithelial cell proliferation, rescuing budding-impaired organoids, and enhancing intestinal barrier function in vitro and in vivo models.
Article
Food Science & Technology
Yifang Cao, Donggen Zhou, Xiaowei Zhang, Xinglong Xiao, Yigang Yu, Xiaofeng Li
Summary: The combination of citral and carvacrol exhibited a synergistic effect on inhibiting the growth of Cronobacter sakazakii, leading to more severe cell damage and potential use in eradicating the bacteria in infant formula.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Pediatrics
Yasser Elsayed, Mary Seshia
Summary: Clinical management of gut injury remains challenging due to the lack of defined diagnostic criteria. This report introduces an integrated approach using intestinal ultrasound as the primary assessment tool along with other clinical and biochemical markers. This algorithm improves the quality of care, provides more accurate diagnosis of NEC, and differentiates other types of gut injury.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Pediatrics
Linghao Cai, Dengming Lai, Jiafang Gao, Hao Wu, Bo Shi, Haosen Ji, Jinfa Tou
Summary: This article summarizes the role of miRNAs in neonatal necrotizing enterocolitis (NEC) and potential therapeutic targets for NEC.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Yan-Chun Ji, Qian Sun, Chun-Yan Fu, Xiang She, Xiao-Chen Liu, Yu He, Qing Ai, Lu-Quan Li, Zheng-Li Wang
Summary: The study found that in a mouse model of necrotizing enterocolitis (NEC), exogenous AI-2 partially reversed flora disorder and reduced inflammation levels.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Immunology
Jiaqi Wei, Zhaoli Meng, Zhenyu Li, Dan Dang, Hui Wu
Summary: Necrotizing enterocolitis (NEC) is an inflammatory intestinal disease that significantly impacts preterm infants. The immature immune system of preterm infants makes them susceptible to gut inflammatory disorders. Intestinal macrophages play a crucial role in the pathogenesis of NEC and their plasticity and diversity affect intestinal development, pathogen resistance, intestinal barrier maintenance, and gut microbiota regulation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Yanpeng Yang, Sheng Ma, Kailun Guo, Du Guo, Jiahui Li, Muxue Wang, Yutang Wang, Chunling Zhang, Xiaodong Xia, Chao Shi
Summary: This study found that combined LED illumination and citral treatment can effectively reduce the abundance of C. sakazakii in reconstituted powdered infant formula. The combination treatment also destroys cellular morphology and membrane integrity, and induces lipid peroxidation. Neither LED illumination nor citral treatment results in DNA breakdown in C. sakazakii.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Food Science & Technology
Richard Y. Wu, Bo Li, Rachael G. Horne, Abdalla Ahmed, Dorothy Lee, Shaiya C. Robinson, Haitao Zhu, Marissa Cadete, Mashriq Alganabi, Rachel Filler, Kathene C. Johnson-Henry, Paul Delgado-Olguin, Agostino Pierro, Philip M. Sherman
Summary: Necrotizing enterocolitis (NEC) is a serious gastrointestinal emergency that affects premature infants. Breastmilk helps prevent NEC, in part due to human milk oligosaccharides (HMOs). This study found that different structural HMOs have varying effects on intestinal physiology, with unique mechanisms of action, providing a functional framework for screening and designing HMO-like compounds.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Medicine, Research & Experimental
Yu He, Weixia Du, Sa Xiao, Benhua Zeng, Xiang She, Dong Liu, Hua Du, Luquan Li, Fang Li, Qing Ai, Junli He, Chao Song, Hong Wei, Xiaodong Zhao, Jialin Yu
Summary: The study found differences in the microbiota structure and butyrate levels between NEC patients and healthy controls. In mouse experiments, fecal transplantation from NEC patients resulted in more severe intestinal injuries, and alterations in microbiota and butyrate levels were maintained post-transplantation. The microbiota was implicated in NEC, with the microbial butyrate-T-reg axis identified as a potential mechanism for the observed effects.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Pediatrics
Bo Shi, Cheng-Jie Lyu, Zhen-Kai Le, Hao-Sen Ji, Yi Xiao, Yuan-Yuan Zhang, Shou-Jiang Huang, Lin-Jun Yu, Qiang Shu, Jin-Fa Tou, Deng-Ming Lai
Summary: This study aimed to investigate the role and mechanism of macrophages in regulating acute intestinal injury in neonatal necrotizing enterocolitis (NEC). The results showed that NEC patients had high levels of macrophage infiltration and NLRP3, caspase-1, and IL-1β expression in the intestinal lamina propria compared to healthy patients. In the mouse model, NEC mice with Nlrp3 gene knockout showed improved survival rate, reduced intestinal macrophage proportion, and decreased intestinal injury. Macrophage-derived NLRP3, caspase-1, and IL-1β, as well as macrophage-epithelial cell co-culture supernatant, also caused intestinal epithelial cell injuries. Macrophage activation and NLRP3/caspase-1/IL-1β cellular signals may be crucial in NEC development and serve as potential therapeutic targets for NEC treatment.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Ming Yue, Heying Yang, Mingxia Cui, Yuhang Yuan, Ning Zhang, Xiangyu Zhang, Yan Li
Summary: Santulli enterostomy is a simple and safe surgical procedure that provides early restoration of intestinal continuity without formal laparotomy. Compared to traditional ostomy procedures, Santulli enterostomy has shorter operative time, shorter hospital stay, and lower incidence of postoperative complications.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Willemien S. Kalteren, Arend F. Bos, Willem van Oeveren, Jan B. F. Hulscher, Elisabeth M. W. Kooi
Summary: The study found that urinary I-FABP levels were higher in anemic preterm infants before transfusion compared to non-anemic controls, indicating a link between anemia and intestinal injury. Anemia may result in reduced splanchnic oxygen saturation and intestinal tissue hypoxia, contributing to the development of NEC. Lower hemoglobin levels were associated with higher urinary I-FABP levels in anemic preterm infants, supporting the hypothesis that anemia leads to intestinal cell injury and potentially NEC.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Shan He, Gang Liu, Xueping Zhu
Summary: This study demonstrates the beneficial effects of human breast milk-derived exosomes in preventing necrotizing enterocolitis by reducing inflammation and injury, and restoring intestinal tight-junction proteins.
PEDIATRIC RESEARCH
(2021)
Article
Infectious Diseases
Yi Sun, Xueyan Hu, Du Guo, Chao Shi, Chunling Zhang, Xiaoli Peng, Hua Yang, Xiaodong Xia
MICROBIAL DRUG RESISTANCE
(2019)
Article
Microbiology
Yichen Bai, Haibo Yu, Du Guo, Shengyi Fei, Chao Shi
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Food Science & Technology
Du Guo, Zeyu Yang, Xiaoying Zheng, Shenmin Kang, Zhuokai Yang, Yunfeng Xu, Chao Shi, Hongyu Tian, Xiaodong Xia
FOODBORNE PATHOGENS AND DISEASE
(2019)
Article
Microbiology
Yi Sun, Du Guo, Zi Hua, Huihui Sun, Zhanwen Zheng, Xiaodong Xia, Chao Shi
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Du Guo, Shuo Wang, Jiahui Li, Fangting Bai, Yanpeng Yang, Yunfeng Xu, Sen Liang, Xiaodong Xia, Xin Wang, Chao Shi
Article
Biochemistry & Molecular Biology
Du Guo, Fangting Bai, Xiangjun Zhan, Wenting Zhang, Tong Jin, Yutang Wang, Xiaodong Xia, Chao Shi
Summary: Citral protects Caco-2 cells by inhibiting the adhesion and invasion of C. sakazakii and suppressing inflammatory response and apoptosis. It has the potential to prevent inflammation and mitigate the effects of C. sakazakii in Caco-2 cells.
Article
Food Science & Technology
Du Guo, Yichen Bai, Shengyi Fei, Yanpeng Yang, Jiahui Li, Baowei Yang, Xin Lu, Xiaodong Xia, Chao Shi
Summary: The research findings suggest that 405 nm LED-illumination treatment reduces the resistance of S. Typhimurium to environmental stress and downregulates the transcription levels of environmental tolerance-related genes. These results provide potential application prospects for using LED-illumination technology to control pathogens in food processing and reduce infections and diseases related to S. Typhimurium.
Article
Food Science & Technology
Fangting Bai, Du Guo, Yueyi Wang, Shanbo Zhang, Jiahui Li, Kangkang Zhi, Chao Shi, Xiaodong Xia
Summary: This study investigated the combined bactericidal effect of nisin and thymoquinone on Listeria monocytogenes in Tryptone Soy Broth and sterilized milk. The combination led to a greater reduction in bacterial number and appeared to cause early injury to the bacteria. Nisin and thymoquinone acted on the bacteria in different growth phases and demonstrated a reversible hydrogen-bonding interaction.