Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split‐washer‐type mechanism for substrate unfolding

Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1–Npl4

(2018) Nicholas O. Bodnar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1–Npl4

(2018) Nicholas O. Bodnar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis of p97 Inhibition by the Site-Selective Anti-Cancer Compound CB-5083

(2018) Wai Kwan Tang et al.   MOLECULAR PHARMACOLOGY

Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy

(2017) Emily E. Blythe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104

(2017) Stephanie N. Gates et al.   SCIENCE

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

(2017) Nicholas M. Pearce et al.   Nature Communications

Structure of a AAA+ unfoldase in the process of unfolding substrate

(2017) Zev A Ripstein et al.   eLife

Gentle, fast and effective crystal soaking by acoustic dispensing

(2017) Patrick M. Collins et al.   Acta Crystallographica Section D-Structural Biology

p97 Promotes a Conserved Mechanism of Helicase Unloading during DNA Cross-Link Repair

(2016) George Fullbright et al.   MOLECULAR AND CELLULAR BIOLOGY

VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair

(2016) Johannes van den Boom et al.   MOLECULAR CELL

Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study

(2016) Rui Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2.3 A resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

(2016) S. Banerjee et al.   SCIENCE

Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97

(2016) Petra Hänzelmann et al.   STRUCTURE

Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain

(2016) Wai Kwan Tang et al.   Scientific Reports

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

(2015) Daniel J. Anderson et al.   CANCER CELL

Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)

(2015) Han-Jie Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

(2014) Raymond J Deshaies   BMC BIOLOGY

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis

(2014) H. Meyer et al.   JOURNAL OF CELL SCIENCE

Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction between D1 and D2 ATPase Domains

(2014) Tsui-Fen Chou et al.   JOURNAL OF MOLECULAR BIOLOGY

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

(2013) Paola Magnaghi et al.   Nature Chemical Biology

A Fluorescent, Reagentless Biosensor for ADP Based on Tetramethylrhodamine-Labeled ParM

(2010) Simone Kunzelmann et al.   ACS Chemical Biology

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Analysis of Nucleotide Binding to P97 Reveals the Properties of a Tandem AAA Hexameric ATPase

(2008) Louise C. Briggs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 'glutamate switch' provides a link between ATPase activity and ligand binding in AAA+ proteins

(2008) Xiaodong Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Improved Structures of Full-Length p97, an AAA ATPase: Implications for Mechanisms of Nucleotide-Dependent Conformational Change

(2008) Jason M. Davies et al.   STRUCTURE