Immune‐mediated ECM depletion improves tumour perfusion and payload delivery

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

(2018) Marsha C. Lampi et al.   Science Translational Medicine

Type I collagen–targeted PET probe for pulmonary fibrosis detection and staging in preclinical models

(2017) Pauline Désogère et al.   Science Translational Medicine

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

(2017) Claire Vennin et al.   Science Translational Medicine

Tumor Stiffening, a Key Determinant of Tumor Progression, is Reversed by Nanomaterial-Induced Photothermal Therapy

(2017) Iris Marangon et al.   Theranostics

ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

(2016) Nicola Rath et al.   EMBO Molecular Medicine

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

(2016) N. N. Rahbari et al.   Science Translational Medicine

Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue

(2015) B. F. Kennedy et al.   CANCER RESEARCH

Current mechanistic insights into the roles of matrix metalloproteinases in tumour invasion and metastasis

(2015) Gordon T Brown et al.   JOURNAL OF PATHOLOGY

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

(2015) Ignazio Caruana et al.   NATURE MEDICINE

Intratumoral LIGHT Restores Pericyte Contractile Properties and Vessel Integrity

(2015) Anna Johansson-Percival et al.   Cell Reports

Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography

(2015) Kelsey M. Kennedy et al.   Scientific Reports

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Pericellular proteolysis in cancer

(2014) Lisa Sevenich et al.   GENES & DEVELOPMENT

Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid

(2014) A. Schmaus et al.   GLYCOBIOLOGY

Extracellular matrix assembly: a multiscale deconstruction

(2014) Janna K. Mouw et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure

(2014) Brendan F. Kennedy et al.   Biomedical Optics Express

Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases

(2013) Frits Thorsen et al.   JOURNAL OF CONTROLLED RELEASE

Iron Oxide Nanoparticle-Micelles (ION-Micelles) for Sensitive (Molecular) Magnetic Particle Imaging and Magnetic Resonance Imaging

(2013) Lucas W. E. Starmans et al.   PLoS One

Strategies to Increase Drug Penetration in Solid Tumors

(2013) Il-Kyu Choi et al.   Frontiers in Oncology

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Dextran and Polymer Polyethylene Glycol (PEG) Coating Reduce Both 5 and 30 nm Iron Oxide Nanoparticle Cytotoxicity in 2D and 3D Cell Culture

(2012) Miao Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phase I/II study of the tumour-targeting human monoclonal antibody–cytokine fusion protein L19-TNF in patients with advanced solid tumours

(2012) G. Spitaleri et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

(2012) Hélène Salmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Advances in molecular imaging: targeted optical contrast agents for cancer diagnostics

(2012) Anne Hellebust et al.   Nanomedicine

Tumor-targeted TNF  stabilizes tumor vessels and enhances active immunotherapy

(2012) A. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel role for granzymes in anti-tumor immunity

(2012) Sabine Hoves et al.   OncoImmunology

Selection and characterization of tenascin C targeting peptide

(2011) Mee Young Kim et al.   MOLECULES AND CELLS

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

(2011) B. Diop-Frimpong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase II Study of Asparagine-Glycine-Arginine–Human Tumor Necrosis Factor α, a Selective Vascular Targeting Agent, in Previously Treated Patients With Malignant Pleural Mesothelioma

(2010) Vanesa Gregorc et al.   JOURNAL OF CLINICAL ONCOLOGY

Hyaluronidase Expression by an Oncolytic Adenovirus Enhances Its Intratumoral Spread and Suppresses Tumor Growth

(2010) Sonia Guedan et al.   MOLECULAR THERAPY

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

(2009) Kazuki N. Sugahara et al.   CANCER CELL

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

(2009) T. Teesalu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice

(2008) Juliana Hamzah et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteomic analysis of the venom ofHeterometrus longimanus (Asian black scorpion)

(2008) Scott Bringans et al.   PROTEOMICS