Selection on metabolic pathway function in the presence of mutation-selection-drift balance leads to rate-limiting steps that are not evolutionarily stable

Flux Control in Glycolysis Varies Across the Tree of Life

(2016) Alena Orlenko et al.   JOURNAL OF MOLECULAR EVOLUTION

Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast

(2015) Russell A. Hermansen et al.   BMC EVOLUTIONARY BIOLOGY

The Influence of Selection for Protein Stability on dN/dS Estimations

(2014) Pouria Dasmeh et al.   Genome Biology and Evolution

Evolutionary meandering of intermolecular interactions along the drift barrier

(2014) Michael Lynch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Latent Effects of Hsp90 Mutants Revealed at Reduced Expression Levels

(2013) Li Jiang et al.   PLoS Genetics

The relationship between the hierarchical position of proteins in the human signal transduction network and their rate of evolution

(2012) David Alvarez-Ponce   BMC EVOLUTIONARY BIOLOGY

THE EVOLUTION OF GENES IN BRANCHED METABOLIC PATHWAYS

(2012) Mark D. Rausher   EVOLUTION

Evolution of Flux Control in the Glucosinolate Pathway in Arabidopsis thaliana

(2012) Carrie F. Olson-Manning et al.   MOLECULAR BIOLOGY AND EVOLUTION

Protein Quality Control Acts on Folding Intermediates to Shape the Effects of Mutations on Organismal Fitness

(2012) Shimon Bershtein et al.   MOLECULAR CELL

Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network

(2012) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biophysical and structural considerations for protein sequence evolution

(2011) Johan A Grahnen et al.   BMC EVOLUTIONARY BIOLOGY

Estimating the Distribution of Selection Coefficients from Phylogenetic Data Using Sitewise Mutation-Selection Models

(2011) A. U. Tamuri et al.   GENETICS

A biophysical protein folding model accounts for most mutational fitness effects in viruses

(2011) C. S. Wylie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models

(2010) Chen Li et al.   BMC Systems Biology

Comparative Genomics of the Vertebrate Insulin/TOR Signal Transduction Pathway: A Network-Level Analysis of Selective Pressures

(2010) David Alvarez-Ponce et al.   Genome Biology and Evolution

Duplicate retention in signalling proteins and constraints from network dynamics

(2010) O. S. SOYER et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Selection and the Cell Cycle: Positive Darwinian Selection in a Well-Known DNA Damage Response Pathway

(2010) Mary J. O’Connell   JOURNAL OF MOLECULAR EVOLUTION

Evolution under Fluctuating Environments Explains Observed Robustness in Metabolic Networks

(2010) Orkun S. Soyer et al.   PLoS Computational Biology

The Evolution of Control and Distribution of Adaptive Mutations in a Metabolic Pathway

(2009) K. M. Wright et al.   GENETICS

Evolution exacerbates the paradox of the plankton

(2008) N. Shoresh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA