Activation of ATR-related protein kinase upon DNA damage recognition

Adaptation in replicative senescence: a risky business

(2019) Héloïse Coutelier et al.   CURRENT GENETICS

Linking the organization of DNA replication with genome maintenance

(2019) Balveer Singh et al.   CURRENT GENETICS

Versatility of the Mec1ATM/ATR signaling network in mediating resistance to replication, genotoxic, and proteotoxic stresses

(2019) Isaac Corcoles-Saez et al.   CURRENT GENETICS

Dynamics and selective remodeling of the DNA-binding domains of RPA

(2019) Nilisha Pokhrel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ddc2ATRIP promotes Mec1ATR activation at RPA-ssDNA tracts

(2019) Himadri Biswas et al.   PLoS Genetics

Branching the Tel2 pathway for exact fit on phosphatidylinositol 3-kinase-related kinases

(2018) Katsunori Sugimoto   CURRENT GENETICS

Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling

(2018) Michael Charles Lanz et al.   GENES & DEVELOPMENT

The Initial Response of a Eukaryotic Replisome to DNA Damage

(2018) Martin R.G. Taylor et al.   MOLECULAR CELL

A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA

(2018) Luke A. Yates et al.   Nature Communications

Structural Basis of Mec1-Ddc2-RPA Assembly and Activation on Single-Stranded DNA at Sites of Damage

(2017) Ishan Deshpande et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP

(2017) Xuejuan Wang et al.   SCIENCE

Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway

(2016) Stephanie A. Yazinski et al.   Annual Review of Genetics

RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response

(2016) Yuan-Cho Lee et al.   CURRENT BIOLOGY

ETAA1 acts at stalled replication forks to maintain genome integrity

(2016) Thomas E. Bass et al.   NATURE CELL BIOLOGY

Activation of the ATR kinase by the RPA-binding protein ETAA1

(2016) Peter Haahr et al.   NATURE CELL BIOLOGY

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

Dampening DNA damage checkpoint signalling via coordinated BRCT domain interactions

(2015) J. R. Cussiol et al.   EMBO JOURNAL

Dna2 nuclease-helicase structure, mechanism and regulation by Rpa

(2015) Chun Zhou et al.   eLife

Replication protein A: Single-stranded DNA's first responder

(2014) Ran Chen et al.   BIOESSAYS

TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways

(2014) Christopher P. Wardlaw et al.   DNA REPAIR

Rad4 Mainly Functions in Chk1-Mediated DNA Damage Checkpoint Pathway as a Scaffold Protein in the Fission Yeast Schizosaccharomyces pombe

(2014) Ming Yue et al.   PLoS One

Ddc2 Mediates Mec1 Activation through a Ddc1- or Dpb11-Independent Mechanism

(2014) Amitava Bandhu et al.   PLoS Genetics

Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery

(2013) S. Kumar et al.   GENES & DEVELOPMENT

RPA Coordinates DNA End Resection and Prevents Formation of DNA Hairpins

(2013) Huan Chen et al.   MOLECULAR CELL

Relationship of DNA degradation by Saccharomyces cerevisiae Exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection

(2013) E. Cannavo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlling DNA-end resection: a new task for CDKs

(2013) Lorenza P. Ferretti et al.   Frontiers in Genetics

The Rad4TopBP1 ATR-Activation Domain Functions in G1/S Phase in a Chromatin-Dependent Manner

(2012) Su-Jiun Lin et al.   PLoS Genetics

Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment

(2011) Boris Pfander et al.   EMBO JOURNAL

The Unstructured C-terminal Tail of Yeast Dpb11 (Human TopBP1) Protein Is Dispensable for DNA Replication and the S Phase Checkpoint but Required for the G2/M Checkpoint

(2011) Vasundhara M. Navadgi-Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

(2011) Xuefeng Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination

(2010) Susanne M. Germann et al.   DNA REPAIR

DNA Damage Signaling Recruits the Rtt107-Slx4 Scaffolds via Dpb11 to Mediate Replication Stress Response

(2010) Patrice Y. Ohouo et al.   MOLECULAR CELL

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

(2010) Hengyao Niu et al.   NATURE

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

(2010) Petr Cejka et al.   NATURE

Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity

(2010) Magda Granata et al.   PLoS Genetics

Reconstitution of Rad53 Activation by Mec1 through Adaptor Protein Mrc1

(2009) Sheng-hong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Csm3, Tof1, and Mrc1 Form a Heterotrimeric Mediator Complex That Associates with DNA Replication Forks

(2009) Masashige Bando et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Unstructured C-Terminal Tail of the 9-1-1 Clamp Subunit Ddc1 Activates Mec1/ATR via Two Distinct Mechanisms

(2009) Vasundhara M. Navadgi-Patil et al.   MOLECULAR CELL

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

(2008) D. A. Mordes et al.   GENES & DEVELOPMENT

Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase

(2008) Vasundhara M. Navadgi-Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of the Budding Yeast 9-1-1 Complex Is Required for Dpb11 Function in the Full Activation of the UV-Induced DNA Damage Checkpoint

(2008) F. Puddu et al.   MOLECULAR AND CELLULAR BIOLOGY

Mrc1 and DNA Polymerase ɛ Function Together in Linking DNA Replication and the S Phase Checkpoint

(2008) Huiqiang Lou et al.   MOLECULAR CELL

Dpb11 activates the Mec1-Ddc2 complex

(2008) D. A. Mordes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA