Mitochondrial VDAC2 and cell homeostasis: highlighting hidden structural features and unique functionalities

Role of cysteines in mammalian VDAC isoforms' function

(2016) Vito De Pinto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

VDAC2-specific cellular functions and the underlying structure

(2016) Shamim Naghdi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Doughnuts, daisy chains and crescent moons: the quest for the elusive apoptotic pore

(2016) G. Dewson   EMBO JOURNAL

Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis

(2016) L. Grosse et al.   EMBO JOURNAL

VDAC-2: Mitochondrial outer membrane regulator masquerading as a channel?

(2016) Svetlana Rajkumar Maurya et al.   FEBS Journal

Human VDAC isoforms differ in their capability to interact with minocycline and to contribute to its cytoprotective activity

(2016) Andonis Karachitos et al.   MITOCHONDRION

VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications

(2016) Simona Reina et al.   Oncotarget

MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals

(2015) Jia Yuan et al.   Autophagy

The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities

(2015) Carlo Guardiani et al.   BIOCHEMISTRY

VDAC3 gating is activated by suppression of disulfide-bond formation between the N-terminal region and the bottom of the pore

(2015) Masateru Okazaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The mitochondrial voltage-dependent anion channel 1 in tumor cells

(2015) Varda Shoshan-Barmatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

N-helix and Cysteines Inter-regulate Human Mitochondrial VDAC-2 Function and Biochemistry

(2015) Svetlana Rajkumar Maurya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease

(2015) Tatiana K. Rostovtseva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome

(2015) Gerardo G. Piroli et al.   MOLECULAR & CELLULAR PROTEOMICS

The proteomic 2D-DIGE approach reveals the protein voltage-dependent anion channel 2 as a potential therapeutic target in epithelial thyroid tumours

(2015) Eugenia Mato et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Cell-free production of VDAC directly into liposomes for integration with biomimetic membrane systems

(2015) Lavinia Liguori et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis

(2015) Shamim Naghdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermodynamic, structural and functional properties of membrane protein inclusion bodies are analogous to purified counterparts: case study from bacteria and humans

(2015) Ankit Gupta et al.   RSC Advances

Inspired and stabilized by nature: ribosomal synthesis of the human voltage gated ion channel (VDAC) into 2D-protein-tethered lipid interfaces

(2015) Samar Damiati et al.   Biomaterials Science

Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity

(2015) Hirohito Shimizu et al.   eLife

Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis

(2015) Shubhra Majumder et al.   Cells

Plant VDAC Selectivity and Voltage-Dependence are Uncoupled

(2015) Hayet Saidani et al.   BIOPHYSICAL JOURNAL

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

(2014) S B Ma et al.   CELL DEATH AND DIFFERENTIATION

Membrane protein synthesis in cell-free systems: From bio-mimetic systems to bio-membranes

(2014) Rita Sachse et al.   FEBS LETTERS

High Resolution Structure and Double Electron-Electron Resonance of the Zebrafish Voltage-dependent Anion Channel 2 Reveal an Oligomeric Population

(2014) Johann Schredelseker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translocation of Glycogen Synthase Kinase-3β (GSK-3β), a Trigger of Permeability Transition, Is Kinase Activity-dependent and Mediated by Interaction with Voltage-dependent Anion Channel 2 (VDAC2)

(2014) Masaya Tanno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria-associated Endoplasmic Reticulum Membrane (MAM) Regulates Steroidogenic Activity via Steroidogenic Acute Regulatory Protein (StAR)-Voltage-dependent Anion Channel 2 (VDAC2) Interaction

(2014) Manoj Prasad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solid-state NMR, electrophysiology and molecular dynamics characterization of human VDAC2

(2014) Zrinka Gattin et al.   JOURNAL OF BIOMOLECULAR NMR

Influence of Protein – Micelle Ratios and Cysteine Residues on the Kinetic Stability and Unfolding Rates of Human Mitochondrial VDAC-2

(2014) Svetlana Rajkumar Maurya et al.   PLoS One

Cysteine Residues Impact the Stability and Micelle Interaction Dynamics of the Human Mitochondrial β-Barrel Anion Channel hVDAC-2

(2014) Svetlana Rajkumar Maurya et al.   PLoS One

Charged Residues Distribution Modulates Selectivity of the Open State of Human Isoforms of the Voltage Dependent Anion-Selective Channel

(2014) Giuseppe Federico Amodeo et al.   PLoS One

Structural insights into proapoptotic signaling mediated by MTCH2, VDAC2, TOM40 and TOM22

(2013) Valery G.Veresov et al.   CELLULAR SIGNALLING

Cysteine Oxidative Posttranslational Modifications

(2013) Heaseung S. Chung et al.   CIRCULATION RESEARCH

Modulation of Human Mitochondrial Voltage-dependent Anion Channel 2 (hVDAC-2) Structural Stability by Cysteine-assisted Barrel-lipid Interactions

(2013) Svetlana Rajkumar Maurya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-dependent Anion Channels Modulate Mitochondrial Metabolism in Cancer Cells

(2013) Eduardo N. Maldonado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-Dependent Anion Channel-2 Interaction with Nitric Oxide Synthase Enhances Pulmonary Artery Endothelial Cell Nitric Oxide Production

(2012) Cristina M. Alvira et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Coupling of ryanodine receptor 2 and voltage-dependent anion channel 2 is essential for Ca2+transfer from the sarcoplasmic reticulum to the mitochondria in the heart

(2012) Choon Kee Min et al.   BIOCHEMICAL JOURNAL

The Isoform Specific N Terminus of VDAC2 is Dispensable for tBid Induced Cytochrome C Release

(2012) Shamim Naghdi et al.   BIOPHYSICAL JOURNAL

Disruption of the VDAC2–Bak interaction by Bcl-xS mediates efficient induction of apoptosis in melanoma cells

(2012) M Plötz et al.   CELL DEATH AND DIFFERENTIATION

Cytosolic Bax

(2012) Sandra Vogel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-dependent Anion Channels (VDACs) Recruit Parkin to Defective Mitochondria to Promote Mitochondrial Autophagy

(2012) Yu Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Charge Profile Analysis Reveals That Activation of Pro-apoptotic Regulators Bax and Bak Relies on Charge Transfer Mediated Allosteric Regulation

(2012) Crina-Maria Ionescu et al.   PLoS Computational Biology

VDAC1: from structure to cancer therapy

(2012) Varda Shoshan-Barmatz et al.   Frontiers in Oncology

Functional Model of Metabolite Gating by Human Voltage-Dependent Anion Channel 2

(2011) Andras J. Bauer et al.   BIOCHEMISTRY

Plant VDAC: Facts and speculations

(2011) Fabrice Homblé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

VDAC isoforms in mammals

(2011) Angela Messina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Solution NMR spectroscopic characterization of human VDAC-2 in detergent micelles and lipid bilayer nanodiscs

(2011) Tsyr-Yan Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Voltage-dependent anion channel 2 modulates resting Ca2+ sparks, but not action potential-induced Ca2+ signaling in cardiac myocytes

(2011) Krishna Prasad Subedi et al.   CELL CALCIUM

Reversible molecular pathology of skeletal muscle in spinal muscular atrophy

(2011) Chantal A. Mutsaers et al.   HUMAN MOLECULAR GENETICS

Critical Role for Voltage-Dependent Anion Channel 2 in Infectious Bursal Disease Virus-Induced Apoptosis in Host Cells via Interaction with VP5

(2011) Z. Li et al.   JOURNAL OF VIROLOGY

The Use of Anti-VDAC2 Antibody for the Combined Assessment of Human Sperm Acrosome Integrity and Ionophore A23187-Induced Acrosome Reaction

(2011) Bianjiang Liu et al.   PLoS One

VDAC1 cysteine residues: topology and function in channel activity and apoptosis

(2010) Lior Aram et al.   BIOCHEMICAL JOURNAL

Origami in outer membrane mimetics: correlating the first detailed images of refolded VDAC with over 20 years of biochemical data

(2010) William A.T. Summers et al.   Biochemistry and Cell Biology

Modulation of Plant Mitochondrial VDAC by Phytosterols

(2010) Lamia Mlayeh et al.   BIOPHYSICAL JOURNAL

Swapping of the N-terminus of VDAC1 with VDAC3 restores full activity of the channel and confers anti-aging features to the cell

(2010) Simona Reina et al.   FEBS LETTERS

Voltage-dependent anion-selective channel (VDAC) in the plasma membrane

(2010) Vito De Pinto et al.   FEBS LETTERS

Mitochondrial protein import and the genesis of steroidogenic mitochondria

(2010) Andrew Midzak et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Mitophagy: the latest problem for Parkinson's disease

(2010) Cristofol Vives-Bauza et al.   TRENDS IN MOLECULAR MEDICINE

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Apoptosis: it's BAK to VDAC

(2009) Gordon C. Shore   EMBO REPORTS

VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria

(2009) Soumya Sinha Roy et al.   EMBO REPORTS

Proteomic DIGE analysis of the mitochondria-enriched fraction from aged rat skeletal muscle

(2009) Kathleen O'Connell et al.   PROTEOMICS

The published 3D structure of the VDAC channel: native or not?

(2009) Marco Colombini   TRENDS IN BIOCHEMICAL SCIENCES

Molecular and functional characterization of VDAC2 purified from mammal spermatozoa

(2008) Viviana A. Menzel et al.   BIOSCIENCE REPORTS

Regulation of hexokinase binding to VDAC

(2008) John G. Pastorino et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

(2008) Federica Chiara et al.   PLoS One

Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration

(2008) T. K. Rostovtseva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the human voltage-dependent anion channel

(2008) M. Bayrhuber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating

(2008) R. Ujwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution Structure of the Integral Human Membrane Protein VDAC-1 in Detergent Micelles

(2008) S. Hiller et al.   SCIENCE