Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3

PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity

(2016) Eyad Kalawy Fansa et al.   Nature Communications

Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3

(2015) Shobhna Kapoor et al.   BIOPHYSICAL JOURNAL

Specificity of Lipoprotein Chaperones for the Characteristic Lipidated Structural Motifs of their Cognate Lipoproteins

(2015) Tom Mejuch et al.   CHEMBIOCHEM

The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function

(2015) Mandy Lokaj et al.   STRUCTURE

A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins

(2015) Katja Gotthardt et al.   eLife

How do cilia organize signalling cascades?

(2014) M. V. Nachury   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis

(2013) YuKyung Lee et al.   CELL CYCLE

A HomozygousPDE6DMutation in Joubert Syndrome Impairs Targeting of Farnesylated INPP5E Protein to the Primary Cilium

(2013) Sophie Thomas et al.   HUMAN MUTATION

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

(2013) Gunther Zimmermann et al.   NATURE

Consequences of a Mutation in the UNC119 Gene for T Cell Function in Idiopathic CD4 Lymphopenia

(2012) Magdalena M. Gorska et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119

(2012) Shehab A Ismail et al.   EMBO JOURNAL

Uncoordinated (UNC)119: Coordinating the trafficking of myristoylated proteins

(2012) Ryan Constantine et al.   VISION RESEARCH

Transport and localization of signaling proteins in ciliated cells

(2012) Mehdi Najafi et al.   VISION RESEARCH

The prenyl-binding protein PrBP/δ: A chaperone participating in intracellular trafficking

(2012) Houbin Zhang et al.   VISION RESEARCH

Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways

(2011) Liyun Sang et al.   CELL

An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium

(2011) K. J. Wright et al.   GENES & DEVELOPMENT

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

(2011) Anchal Chandra et al.   NATURE CELL BIOLOGY

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

(2011) Shehab A Ismail et al.   Nature Chemical Biology

UNC119 is required for G protein trafficking in sensory neurons

(2011) Houbin Zhang et al.   NATURE NEUROSCIENCE

Ciliopathies: an expanding disease spectrum

(2011) Aoife M. Waters et al.   PEDIATRIC NEPHROLOGY

Steric volume exclusion sets soluble protein concentrations in photoreceptor sensory cilia

(2011) M. Najafi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The retinitis pigmentosa protein RP2 interacts with polycystin 2 and regulates cilia-mediated vertebrate development

(2010) Toby Hurd et al.   HUMAN MOLECULAR GENETICS

The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium

(2010) R. Jane Evans et al.   HUMAN MOLECULAR GENETICS

Planar Cell Polarity Acts Through Septins to Control Collective Cell Movement and Ciliogenesis

(2010) Su Kyoung Kim et al.   SCIENCE

A Septin Diffusion Barrier at the Base of the Primary Cilium Maintains Ciliary Membrane Protein Distribution

(2010) Q. Hu et al.   SCIENCE

The Primary Cilium as a Complex Signaling Center

(2009) Nicolas F. Berbari et al.   CURRENT BIOLOGY

Septins and the Lateral Compartmentalization of Eukaryotic Membranes

(2009) Fabrice Caudron et al.   DEVELOPMENTAL CELL

Flagellar membrane localization via association with lipid rafts

(2009) K. M. Tyler et al.   JOURNAL OF CELL SCIENCE

Uncoordinated 119 Protein Controls Trafficking of Lck via the Rab11 Endosome and Is Critical for Immunological Synapse Formation

(2009) M. M. Gorska et al.   JOURNAL OF IMMUNOLOGY

Cystin Localizes to Primary Cilia via Membrane Microdomains and a Targeting Motif

(2009) B. Tao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Unc119 Protects from Shigella Infection by Inhibiting the Abl Family Kinases

(2009) Ramarao Vepachedu et al.   PLoS One

High-throughput generation of tagged stable cell lines for proteomic analysis

(2009) Jorge Z. Torres et al.   PROTEOMICS

Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex

(2008) Stefan Veltel et al.   FEBS LETTERS

The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3

(2008) Stefan Veltel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Comparison of the Predictive Performance of Different Methods of Kidney Function Estimation in a Well-Characterized HIV-Infected Population

(2008) Katherine Barraclough et al.   NEPHRON CLINICAL PRACTICE