Population pharmacokinetics of vactosertib, a new TGF-β receptor type Ι inhibitor, in patients with advanced solid tumors

Population Pharmacokinetics of Upadacitinib Using the Immediate-Release and Extended-Release Formulations in Healthy Subjects and Subjects with Rheumatoid Arthritis: Analyses of Phase I–III Clinical Trials

(2019) Ben Klünder et al.   CLINICAL PHARMACOKINETICS

Pharmacokinetic characteristics of vactosertib, a new activin receptor-like kinase 5 inhibitor, in patients with advanced solid tumors in a first-in-human phase 1 study

(2019) Su Young Jung et al.   INVESTIGATIONAL NEW DRUGS

A population pharmacokinetic model of cabozantinib in healthy volunteers and patients with various cancer types

(2018) Steven Lacy et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Association of TGF-β responsive signature with anti-tumor effect of vactosertib, a potent, oral TGF-β receptor type I (TGFBRI) inhibitor in patients with advanced solid tumors.

(2018) Vicki Leigh Keedy et al.   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive Guidance for Antibiotic Dosing in Obese Adults

(2017) Lina Meng et al.   PHARMACOTHERAPY

Preconditioning of Nonlinear Mixed Effects Models for Stabilisation of Variance-Covariance Matrix Computations

(2016) Yasunori Aoki et al.   AAPS Journal

Population Pharmacokinetic Modeling To Estimate the Contributions of Genetic and Nongenetic Factors to Efavirenz Disposition

(2016) Jason D. Robarge et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

TGF-β Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1α-Induced Epithelial Mesenchymal Transition

(2016) Min-Jin Kim et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Population Pharmacokinetic and Covariate Analysis of Apatinib, an Oral Tyrosine Kinase Inhibitor, in Healthy Volunteers and Patients with Solid Tumors

(2016) Mingming Yu et al.   CLINICAL PHARMACOKINETICS

A population pharmacokinetic model for perioperative dosing of factor VIII in hemophilia A patients

(2016) H. Hazendonk et al.   HAEMATOLOGICA

A population pharmacokinetic model for perioperative dosing of factor VIII in hemophilia A patients

(2016) H. Hazendonk et al.   HAEMATOLOGICA

Pathophysiology after pancreaticoduodenectomy

(2015) Chang Moo Kang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Covariate selection in pharmacometric analyses: a review of methods

(2014) Matthew M. Hutmacher et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Discovery of N-((4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): A Highly Potent, Selective, and Orally Bioavailable Inhibitor of TGF-β Type I Receptor Kinase as Cancer Immunotherapeutic/Antifibrotic Agent

(2014) Cheng Hua Jin et al.   JOURNAL OF MEDICINAL CHEMISTRY

EW-7197, a Novel ALK-5 Kinase Inhibitor, Potently Inhibits Breast to Lung Metastasis

(2014) J. Y. Son et al.   MOLECULAR CANCER THERAPEUTICS

Quantification of Gastrointestinal Liquid Volumes and Distribution Following a 240 mL Dose of Water in the Fasted State

(2014) Deanna M. Mudie et al.   MOLECULAR PHARMACEUTICS

Defining a therapeutic window for the novel TGF-β inhibitor LY2157299 monohydrate based on a pharmacokinetic/pharmacodynamic model

(2013) Ivelina Gueorguieva et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Busulfan in Infant to Adult Hematopoietic Cell Transplant Recipients: A Population Pharmacokinetic Model for Initial and Bayesian Dose Personalization

(2013) Jeannine S. McCune et al.   CLINICAL CANCER RESEARCH

Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes

(2013) Jeong-Hwan Yoon et al.   EMBO Molecular Medicine

Factors associated with delayed gastric emptying after pancreaticoduodenectomy

(2013) Abhishek D. Parmar et al.   HPB

Covariate Pharmacokinetic Model Building in Oncology and its Potential Clinical Relevance

(2012) Markus Joerger   AAPS Journal

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

Impact of Pharmacometric Analyses on New Drug Approval and Labelling Decisions

(2011) Joo Yeon Lee et al.   CLINICAL PHARMACOKINETICS

Obesity and Allometric Scaling of Pharmacokinetics

(2011) Douglas J. Eleveld et al.   CLINICAL PHARMACOKINETICS

Implications of Obesity for Drug Therapy: Limitations and Challenges

(2011) R Jain et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

(2010) Li Yang et al.   TRENDS IN IMMUNOLOGY

Dose Escalation Methods in Phase I Cancer Clinical Trials

(2009) Christophe Le Tourneau et al.   JNCI-Journal of the National Cancer Institute

Effect of the preliminary hydration on gastric emptying time for water in healthy volunteers

(2008) T. UMENAI et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA