Article
Cell Biology
Yu-Ling Sun, Tao Bai, Lin Zhou, Rong-Tao Zhu, Wei-Jie Wang, Ruo-Peng Liang, Jian Li, Chi-Xian Zhang, Jian-Jun Gou
Summary: The study reveals that deficiency of SOD3 accelerates HSC activation and EMT process, thereby promoting liver fibrosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Gengming Niu, Xiaotian Zhang, Runqi Hong, Ximin Yang, Jiawei Gu, Tao Song, Zhiqing Hu, Liang Chen, Xin Wang, Jie Xia, Zhongwei Ke, Jun Ren, Liang Hong
Summary: The study found that GJA1 is significantly increased in HCCs and hepatic cirrhosis, and overexpressed in pulmonary metastases from HCCs. Overexpression of GJA1 promoted proliferation and migration of HSCs and HCC cells. The potential mechanism suggests that GJA1 promotes HCC progression by inducing HSC activation and EMT in HSCs and HCCLM3 cells.
Review
Cell Biology
Hanghang Wu, Chaobo Chen, Siham Ziani, Leonard J. Nelson, Matias A. Avila, Yulia A. Nevzorova, Francisco Javier Cubero
Summary: Cholestatic liver diseases like PBC and PSC are associated with liver fibrogenesis, which can lead to cirrhosis. However, the relationship between liver fibrosis development and cholestatic liver disease progression remains unclear. Periductular fibroblasts differ biologically from hepatic stellate cells, and fibrotic events in these conditions are related to complex crosstalk between immune/inflammatory mechanisms, cytokine signaling, and disrupted homeostasis between cholangiocytes and mesenchymal cells.
Article
Biotechnology & Applied Microbiology
Wenwen Ding, Danhua Zhou, Shimeng Zhang, Jiaping Qian, Lingxia Yang, Lei Tang
Summary: This study demonstrates that Trimetazidine (TMZ) can inhibit liver fibrosis and hepatic stellate cell proliferation induced by CCl4 and TGF-beta. TMZ exerts its effects by blocking the activation of TGF beta/Smad signaling pathway. These findings provide new insights into the potential application of TMZ in the treatment of liver fibrosis.
Article
Multidisciplinary Sciences
Xiongqun Peng, Huixiang Yang, Lijian Tao, Jingni Xiao, Ya Zeng, Yueming Shen, Xueke Yu, Fei Zhu, Jiao Qin
Summary: This study investigated the therapeutic effect of the antifibrotic drug fluorofenidone on liver fibrosis and its mechanism. The results showed that fluorofenidone alleviates liver fibrosis by inhibiting hepatic stellate cell autophagy via the involvement of SMAD2/SMAD3 and autophagy.
Article
Biochemistry & Molecular Biology
Zewei Zhao, Siqi Liu, Shiya Luo, Lin Zhou, Junxi Liu, Bingxiu Qian, Jianglin Shi, Yayun Zhou, Jin Li, Tao Jiang, Zhiyue Lv, Zhonghan Yang
Summary: IL-25 exhibits a protective effect against ANIT-induced cholestatic liver injury by regulating bile acid secretion.
Article
Plant Sciences
Qianyan Gao, Guodong Li, Yue Zu, Yanjiao Xu, Congyi Wang, Dong Xiang, Wenxi He, Tianze Shang, Xinwei Cheng, Dong Liu, Chengliang Zhang
Summary: Ginseng has the potential to treat liver and gallbladder diseases and alleviate liver injury caused by bile accumulation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Gastroenterology & Hepatology
Zhong-Yang Jiang, Xi-Mei Ma, Xiao-Hui Luan, Zhen-Yu Liuyang, Yi-Yang Hong, Yuan Dai, Qing-Hua Dong, Guan-Yu Wang
Summary: This study found that BMI-1 is overexpressed in CRC liver metastasis and activates HSCs to secrete prometastatic factors, thereby creating a conducive environment for metastasis in the liver. In addition, HSCs also promote proliferation, migration, and EMT in CRC cells through the TGF-beta/SMAD pathway.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soonjae Hwang, Sangbin Park, Uzma Yaseen, Ho-Jae Lee, Ji-Young Cha
Summary: Liver fibrosis is a progressive and debilitating disease characterized by excessive deposition of extracellular matrix proteins. Our study reveals that KLF10 acts as a negative regulator of TGF-beta signaling pathway, suppressing hepatic stellate cell activation and fibrogenesis through modulation of ATF3 expression. Targeting the KLF10-ATF3 axis may have therapeutic implications for liver fibrosis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Minako Sakurai, Peter Weber, Gretchen Wolff, Annika Wieder, Julia Szendroedi, Stephan Herzig, Bilgen Ekim uestuenel
Summary: Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and liver fibrosis are progressive liver diseases associated with metabolic syndrome. The elevated expression of TSC22D4 in patients with type 2 diabetes, NAFLD, and NASH suggests its involvement in the progression of these diseases. The study reveals that TSC22D4 contributes to the activation, proliferation, and migration of hepatic stellate cells (HSCs), implicating it as a key regulator in the development of liver fibrosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ji Hye Yang, Sae Kwang Ku, Il Je Cho, Je Hyeon Lee, Chang-Su Na, Sung Hwan Ki
Summary: Neoagarooligosaccharides (NAOs) have protective effects against hepatic fibrosis and inhibit the TGF-beta/Smad signaling pathway. This was validated in in vitro experiments and mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lonneke Rotteveel, Kondababu Kurakula, Esther J. M. Kooijman, Robert C. Schuit, Mariska Verlaan, Maxime Schreurs, Wissam Beaino, Maarten A. H. van Dinther, Peter ten Dijke, Adriaan A. Lammertsma, Alex J. Poot, Harm Jan Bogaard, Albert D. Windhorst
Summary: This translated passage introduces the role of the transforming growth factor beta (TGF beta) pathway and its key mediator ALK5 in cancer and other diseases, and discusses the development of ALK5 PET tracers for studying its function.
NUCLEAR MEDICINE AND BIOLOGY
(2022)
Article
Physiology
Yongxin Wang, Bin Chen, Chengcheng Xiao, Jiang Yu, Xiangyang Bu, Fengxing Jiang, Weijie Ding, Zhong Ge
Summary: miR-183-5p plays a significant role in liver fibrosis, potentially promoting cholestatic liver fibrosis by inhibiting FOXO1 expression. Inhibiting miR-183-5p may be a novel approach to prevent and improve liver fibrosis.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sam Seok Cho, Ji Hye Yang, Ji Hyun Lee, Jin Sol Baek, Sae Kwang Ku, Il Je Cho, Kyu Min Kim, Sung Hwan Ki
Summary: The study suggests that ferroptosis contributes to the progression of hepatic fibrosis by activating hepatic stellate cells and increasing the expression of fibrosis markers.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Kai-li Fu, Pan Chen, Yan-ying Zhou, Yi-ming Jiang, Yue Gao, Hui-zhen Zhang, Li-huan Guan, Cong-hui Wang, Jun-ling Liu, Min Huang, Hui-chang Bi
Summary: Hepatic deficiency of Vps33b exacerbates cholestatic liver injury, leading to abnormal serum markers and liver function, as well as altered metabolism of bile acids. Metabolomics analysis reveals that Vps33b deficiency changes the profile of bile acids, accompanied by alterations in gene expression of bile acid metabolizing enzymes and transporters.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Biochemistry & Molecular Biology
So-Yeon Park, Jeong-Seok Nam
EXPERIMENTAL AND MOLECULAR MEDICINE
(2020)
Editorial Material
Medicine, General & Internal
So-Yeon Park, Jeong-Seok Nam
Review
Biochemistry & Molecular Biology
Yoojin Seo, So-Yeon Park, Hyung-Sik Kim, Jeong-Seok Nam
Article
Biochemistry & Molecular Biology
Jang-Hyun Choi, Tae-Young Jang, So-El Jeon, Jee-Heun Kim, Choong-Jae Lee, Hyeon-Ji Yun, Ji-Youn Jung, So-Yeon Park, Jeong-Seok Nam
Summary: Recurrence and metastasis are main challenges in CRC treatment, driven by a small subpopulation of cells called cancer stem-like cells (CSCs). Transcriptomic profiling showed upregulation of Wnt pathway and stemness genes in metastatic tumors, and treatment with small-molecule Wnt inhibitor ICG-001 effectively suppressed CSC behavior and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
So-Yeon Park, Jee-Heun Kim, Jang-Hyun Choi, Choong-Jae Lee, Won-Jae Lee, Sehoon Park, Zee-Yong Park, Jeong-Heum Baek, Jeong-Seok Nam
Summary: This study highlights the important role of lipid rafts (LRs) in colorectal cancer, where an LR-disrupting alkylphospholipid drug can suppress CSC populations and their self-renewal activities. By inhibiting the LR/CHEK1 axis, the drug forces CSCs to enter inappropriate mitosis, leading to catastrophic cell death.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Hyung Cheoul Shim, Juho Kim, So Yeon Park, Bong Sung Kim, Bongkyun Jang, Hak-Joo Lee, Areum Kim, Seungmin Hyun, Jae-Hyun Kim
Summary: In this study, color conversion layers (CCLs) for full-color micro-LED display were successfully fabricated using a perovskite quantum dot (PQD)/siloxane composite. The PQD was ligand exchanged with a silane compound and then surface activated using a halide-anion containing salt, allowing non-polar organic solvents to be used without damaging the PQD. The ligand-exchanged PQD exhibited high dispersibility and excellent atmospheric stability in the siloxane matrix. The resulting full-color micro-LED display achieved a resolution of about 25.4 pixels per inch (PPI) with a 1 mm pixel pitch, and demonstrated the possibility of a flexible display that can be operated without damage even with a bending radius of 5 mm.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jang-Hyun Choi, So-Yeon Park, Choong-Jae Lee, Jee-Heun Kim, Tae -Young Jang, So -El Jeon, Youngsoo Jun, Jeong-Seok Nam
Summary: Autophagy has both pro-survival and pro-death functions in cancer, depending on the context. In this study, the researchers investigated the expression patterns of SNAREs, a family of proteins involved in autophagy, in colorectal cancer (CRC) tissues. They found that SEC22B, a vesicle SNARE, was highly expressed in tumor tissues, especially in metastatic tissues. Knocking down SEC22B inhibited CRC cell survival and growth, particularly under stressful conditions, and reduced the number of stress-induced autophagic vacuoles. Furthermore, SEC22B knockdown attenuated liver metastasis in a CRC cell xenograft mouse model. This study suggests that SEC22B plays a crucial role in enhancing the aggressiveness of CRC cells and may be a potential therapeutic target.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Jee Heon Rhee, Brian Schermer, Gisung Han, So Yeon Park, Kyung Hoon Lee
Summary: This study examines the effects of natural exposure in indoor environments on restoration quality and cognitive ability. The results show that indoor environments with nature have restorative and cognitive benefits compared to baseline conditions.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
So Yeon Park, Sung-Hwan Choi, Hyung-Seog Yu, Su-Jung Kim, Hoon Kim, Ki Beom Kim, Jung-Yul Cha
Summary: This study compared the thickness and gap width of thermoformed and 3D-printed clear aligners using micro-CT, and evaluated their translucency using spectrophotometer. The results showed that the translucency of the 3D-printed CAs varied depending on the cleaning methods, with the PC group having higher translucency than the PA group. Thermoformed CAs had a decrease in thickness after the manufacturing process, while 3D-printed CAs had an increase in thickness.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Gabriele Colozza, So-Yeon Park, Bon-Kyoung Koo
Summary: Tumors gain a competitive edge over intestinal stem cells by exploiting the self-renewal processes of the stem cells. The dynamics of stem cells in the intestines are regulated by a network of molecular signals and competition for limited space. The Wnt signaling pathway and its inhibitors play a crucial role in maintaining the balance between self-renewal and differentiation. Intestinal cancer cells bypass these regulatory mechanisms, allowing them to outcompete normal cells.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jee-Heun Kim, So-Yeon Park, So-El Jeon, Jang-Hyun Choi, Choong-Jae Lee, Tae-Young Jang, Hyeon-Ji Yun, Yuno Lee, Pilho Kim, Sang Hee Cho, Ji Shin Lee, Jeong-Seok Nam
Summary: This study identifies a novel mechanism by which DCLK1 regulates the aggressiveness of colorectal cancer (CRC). The researchers found that DCLK1 binds and phosphorylates XRCC5, which leads to the activation of cyclooxygenase-2 and enhanced prostaglandin E2 production, resulting in an inflammatory tumor microenvironment and increased aggressiveness of CRC cells. The inhibition of DCLK1 kinase activity was shown to impair tumor seeding and growth in CRC mouse models. This study expands the understanding of the biological function of DCLK1 in CRC.
Article
Medicine, Research & Experimental
So-Yeon Park, Choong-Jae Lee, Jang-Hyun Choi, Jee-Heun Kim, Won-Jae Lee, Tae-Young Jang, So-El Jeon, Jae-Hyun Kim, Sang-Hee Cho, Ji-Shin Lee, Jeong-Seok Nam
Summary: This study reveals the role of Dysadherin in the progression of colorectal cancer (CRC) by regulating the mechanotransduction pathway, promoting cancer cell growth, migration, and invasion. It highlights Dysadherin as a potential therapeutic target for CRC.
Article
Medicine, Research & Experimental
So-Yeon Park, Ji-Young Kim, Gyu-Beom Jang, Jang-Hyun Choi, Jee-Heun Kim, Choong-Jae Lee, Sunjae Lee, Jeong-Heum Baek, Kwan-Kyu Park, Jin-Man Kim, Hee Jin Chang, Nam-Chul Cho, Jeong-Seok Nam
Summary: This study identified an increased expression of CD45 in CRC (EpCAM+) epithelial cells after CRT treatment. High CD45 expression promoted CRC cell survival upon 5-fluorouracil or radiation treatment, while CD45 depletion sensitized CRC cells to CRT. CD45 was found to be preferentially expressed in cancer stem-like cells (CSCs) and played a crucial role in CSC functions such as cancer initiation, repopulation, and metastasis.
