Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling

Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway

(2018) Bing-Gang Zhou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Liposomal Treatment of Cancer Cells Modulates Uptake Pathway of Polymeric Nanoparticles by Altering Membrane Stiffness

(2018) Shengnan Xiang et al.   Small

Matrine reduces the proliferation of A549 cells via the p53/p21/PCNA/eIF4E signaling pathway

(2017) Zhiyan Lu et al.   Molecular Medicine Reports

Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway

(2017) Xiaoling Wu et al.   ONCOLOGY REPORTS

Matrine derivate MASM uncovers a novel function for ribosomal protein S5 in osteoclastogenesis and postmenopausal osteoporosis

(2017) Xiao Chen et al.   Cell Death & Disease

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015

(2017) et al.   JAMA Oncology

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Matrine suppresses airway inflammation by downregulating SOCS3 expression via inhibition of NF-κB signaling in airway epithelial cells and asthmatic mice

(2016) Daqing Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Matrine: Bioactivities and Structural Modifications

(2016) Jiulin Huang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Matrine downregulates IL-33/ST2 expression in the central nervous system of rats with experimental autoimmune encephalomyelitis

(2016) Xiaoyu Zhao et al.   IMMUNOLOGY LETTERS

Matrine ameliorates spontaneously developed colitis in interleukin-10-deficient mice

(2016) Cong Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Matrine derivate MASM suppresses LPS-induced phenotypic and functional maturation of murine bone marrow-derived dendritic cells

(2016) Jing Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Matrine Derivate MASM Prolongs Survival, Attenuates Inflammation, and Reduces Organ Injury in Murine Established Lethal Sepsis

(2016) Jing Xu et al.   JOURNAL OF INFECTIOUS DISEASES

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Haidong Wang et al.   LANCET

MASM, a Matrine Derivative, Offers Radioprotection by Modulating Lethal Total-Body Irradiation-Induced Multiple Signaling Pathways in Wistar Rats

(2016) Jianzhong Li et al.   MOLECULES

Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy

(2015) Xinlei Yu et al.   Autophagy

Enhanced cellular uptake of nanoparticles by increasing the hydrophobicity of poly(lactic acid) through copolymerization with cell-membrane-lipid components

(2015) Mariam Samadi Moghaddam et al.   CHEMICAL COMMUNICATIONS

Anticancer Advances of Matrine and Its Derivatives

(2015) Jianping Yong et al.   CURRENT PHARMACEUTICAL DESIGN

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

(2015) Edgar Pérez-Herrero et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Matrine induces mitochondrial apoptosis in cisplatin-resistant non-small cell lung cancer cells via suppression of β-catenin/survivin signaling

(2015) HUAN-QIN WANG et al.   ONCOLOGY REPORTS

Matrine Reduces Proliferation of Human Lung Cancer Cells by Inducing Apoptosis and Changing miRNA Expression Profiles

(2014) Yong-Qi Liu et al.   Asian Pacific Journal of Cancer Prevention

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Chloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer

(2014) K. L. Cook et al.   CLINICAL CANCER RESEARCH

Bioactive compound reveals a novel function for ribosomal protein S5 in hepatic stellate cell activation and hepatic fibrosis

(2014) Wei-Heng Xu et al.   HEPATOLOGY

Differential uptake of nanoparticles by endothelial cells through polyelectrolytes with affinity for caveolae

(2014) J. Voigt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-tumor activities of matrine and oxymatrine: literature review

(2014) Yan Liu et al.   TUMOR BIOLOGY

Class III PI3K Vps34: essential roles in autophagy, endocytosis, and heart and liver function

(2013) Nadia Jaber et al.   Annals of the New York Academy of Sciences

ROS inhibitorN-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors

(2013) Marianna Halasi et al.   BIOCHEMICAL JOURNAL

Antiviral activity and underlying molecular mechanisms of Matrine against porcine reproductive and respiratory syndrome virus in vitro

(2013) Na Sun et al.   RESEARCH IN VETERINARY SCIENCE

Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF-κB signaling pathway

(2013) HONGMIN SHAO et al.   Oncology Letters

Hepatoprotective effect of Matrine salvianolic acid B salt on Carbon Tetrachloride-Induced Hepatic Fibrosis

(2012) Hong-Ying Gao et al.   Journal of Inflammation-London

Antiviral Effect of Matrine against Human Enterovirus 71

(2012) Yajun Yang et al.   MOLECULES

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

(2011) Subash C. Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Autophagy by Kinases

(2011) Savitha Sridharan et al.   Cancers

A matter of balance between life and death: Targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy

(2010) Spencer B. Gibson   Autophagy

Synthesis and in vitro inhibitory activity of matrine derivatives towards pro-inflammatory cytokines

(2010) Honggang Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-acetylcysteine, reactive oxygen species and beyond

(2010) Shi-Yong Sun   CANCER BIOLOGY & THERAPY

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells

(2008) Takashi Shingu et al.   INTERNATIONAL JOURNAL OF CANCER

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY