Review
Physics, Applied
Dayun Yan, Alex Horkowitz, Qihui Wang, Michael Keidar
Summary: Selective killing of cancer cells is a key feature of cold atmospheric plasma (CAP), and understanding its underlying mechanism is crucial for CAP-based cancer treatment. In addition, expanding the definition of selectivity from conventional single-cell line cases to coculture cases presents forward-looking perspectives for future development. The newly established physically based treatment strategy offers unprecedented visions to achieve selectivity beyond existing concepts based on reactive species and direct killing effects.
PLASMA PROCESSES AND POLYMERS
(2021)
Article
Materials Science, Multidisciplinary
Yong-Cheol Hong
Summary: The experiment utilized a hollow inner electrode covered with a dielectric tube inserted into an outer electrode to generate a plasma jet, with attributes evaluated through monitoring voltage and current behavior and investigating optical emissions. Discharge patterns in atmospheric-pressure air plasma jet in the form of striations were observed, and the striation mechanism was reported utilizing ion acoustic wave propagation through simple calculations.
Article
Food Science & Technology
Ruixia Chen, Dequan Zhang, Huan Liu, Zhenyu Wang, Teng Hui
Summary: The study demonstrated that using atmospheric nonthermal plasma treatment to replace nitrite can reduce nitrite content, inhibit lipid oxidation, and enhance sensory attributes of roasted lamb, with the optimal treatment duration being 30 minutes.
Article
Biochemistry & Molecular Biology
Pankaj Attri, Nagendra Kumar Kaushik, Neha Kaushik, Dietmar Hammerschmid, Angela Privat-Maldonado, Joey De Backer, Masaharu Shiratani, Eun Ha Choi, Annemie Bogaerts
Summary: This study demonstrates that modifying the lysozyme structure using cold atmospheric plasma can enhance its activity against cancer cells at neutral pH, while causing activity loss at acidic pH. Plasma treatment induced greater structural distortion at acidic pH due to more oxidation of amino acids, resulting in limited structural changes at neutral pH. The plasma-treated lysozyme was found to significantly induce apoptosis in cancer cells, suggesting its potential as a new anticancer drug.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Physics, Multidisciplinary
Nenad Selakovic, Nevenka Gligorijevic, Milena Cavic, Nevena Puac, Gordana Malovic, Sinisa Radulovic, Zoran Lj. Petrovic
Summary: Low temperature plasma sources can generate reactive oxygen and nitrogen species that can potentially induce cancer cell death. This study investigates a plasma needle with precise power control for direct treatment of biological samples. The results show that the plasma has cytotoxic potential against cancer cell lines with lower sensitivity towards normal cells. It can inhibit the proliferation of A549 lung adenocarcinoma cells and induce apoptosis.
EUROPEAN PHYSICAL JOURNAL PLUS
(2023)
Article
Physics, Applied
Hossam Saadawy, Esraa M. Fathi, Islam Elsayed, Janset S. Anzour, Ahmed Zaki, Mohamed El Shaer, Marwan Emara
Summary: Since the development of cold atmospheric plasma (CAP), significant progress has been made in the application of CAP in medicine. In this study, we developed two combined plasma sources to produce in situ plasma-activated air-driven water mist (PAAWM). The PAAWM showed effective antitumor efficacy against both chemosensitive and chemoresistant hepatocellular carcinoma cells, suggesting its potential use alone or in combination with other treatments.
PLASMA PROCESSES AND POLYMERS
(2023)
Article
Chemistry, Multidisciplinary
Yun-Hsuan Chen, Jang-Hsing Hsieh, I-Te Wang, Pei-Ru Jheng, Yi-Yen Yeh, Jyh-Wei Lee, Nima Bolouki, Er-Yuan Chuang
Summary: The study demonstrates that transferred cold atmospheric plasma effectively treats melanoma skin cancer cells without harming non-malignant cells. CAP shows a cytotoxic effect on cancer cells within a short timeframe, while causing minimal damage to non-malignant cells.
APPLIED SCIENCES-BASEL
(2021)
Article
Food Science & Technology
Emine Ozen, Govindaraj Dev Kumar, Abhinav Mishra, Rakesh K. Singh
Summary: Atmospheric cold plasma (ACP) is a non-thermal technology that has the potential to inactivate microorganisms in foods. In this study, ACP was used to investigate the inactivation of E. coli K12, acid-adapted E. coli K12, and E. coli O157:H7 in apple cider. The results showed that ACP could effectively reduce the populations of these bacteria within a short processing time. The pH value of the cider was significantly affected by longer processing times. The gas type had different effects on the inactivation, and ozone was found to play a key role in the process. The findings provide insights into the use of ACP for decontaminating fruit juices.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Engineering, Chemical
Tomasz Czapka, Irena Maliszewska, Angelika Winkler
Summary: The study found that the decontamination efficacy of surgical sutures' biofilms under atmospheric pressure nonthermal plasma treatment is time-dependent, with longer exposure times leading to better results. Combining plasma treatment with washing the biofilms with a phosphate buffered saline was proposed to be more effective than using plasma treatment alone.
PLASMA CHEMISTRY AND PLASMA PROCESSING
(2021)
Article
Plant Sciences
Jana Jiresova, Vladimir Scholtz, Jaroslav Julak, Bozena Sera
Summary: Recently, the use of low-temperature plasmas and plasma-activated water (PAW) in biological research has gained much attention. This article reviews the composition and properties of PAW prepared by different methods, and finds no significant difference between PAW prepared by plasma treatment and that prepared by mixing the active ingredients. The research also shows that PAW promotes germination and growth of wheat grains, and effectively decontaminates bacteria and yeast.
Article
Chemistry, Multidisciplinary
Darien K. Nguyen, Vibin Vargheese, Vinson Liao, Panagiotis Dimitrakellis, Sagar Sourav, Weiqing Zheng, Dionisios G. Vlachos
Summary: The study demonstrates that nonthermal, atmospheric He/O-2 plasma (NTAP) is an efficient and controllable method for removing organic ligands like PVP from nanoparticles, without altering the shape and size of the nanoparticles, making it a more efficient alternative to traditional calcination.
Article
Engineering, Multidisciplinary
Keita Shimada, Ryuki Morita, Masayoshi Mizutani, Tsunemoto Kuriyagawa
Summary: Powder jet deposition (PJD) is a spray coating method that can be done under atmospheric pressure and room temperature. By applying an atmospheric-pressure plasma jet (APPJ) assistance, the deposition rate of PJD can be increased.
PRECISION ENGINEERING-JOURNAL OF THE INTERNATIONAL SOCIETIES FOR PRECISION ENGINEERING AND NANOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Jin-Woo Lee, Kyungsook Kim, Minhyung Jung, Youngsun Kim
Summary: Nonthermal atmospheric pressure (NAP) plasmas have been developed for applications such as wound healing, blood coagulation, and cancer therapy. These plasmas can induce either cell proliferation or cell death depending on the dose, by generating reactive oxygen species. In human skin, the dermal papilla cells (DPCs) in the dermis play a key role in hair regeneration, and can be influenced by NAP-PAM treatment to increase proliferation and delay senescence.
Article
Engineering, Chemical
Hiresh Moradi, Dong-Su Kim, Jae-Kyu Yang, Yoon-Young Chang, Sam-Bae Park, Telma Kamranifard
Summary: Organic dyes, such as azo and xanthene dyes, are commonly used and discharged into wastewater. In order to reclaim dye-polluted wastewater, advanced oxidation processes (AOPs) combined with nonthermal atmospheric pressure plasma (NTAPP) have been utilized. The combined system of NTAPP and UV-C activated persulfate (PSUVP) showed the highest efficiency with over 80% degradation of both Rhodamine B and Congo red in 10 minutes and synergy factors of 2.55 and 5.71, respectively.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Polymer Science
Samira Elaissi, Norah A. M. Alsaif
Summary: A nonthermal atmospheric plasma reactor was used to sterilize polymer surfaces in a biological medium. The study analyzed the behavior of a dielectric barrier discharge (DBD) and its parameters, and found that increasing voltage or frequency increased ionization levels and sterilization efficiency. The study also identified the need for short gap width and oxygen admixture for effective bio-decontamination. These findings can benefit plasma-based pollutant degradation devices.
Article
Engineering, Biomedical
Mian Wang, Pelagie Favi, Xiaoqian Cheng, Negar H. Golshan, Katherine S. Ziemer, Michael Keidar, Thomas J. Webster
ACTA BIOMATERIALIA
(2016)
Article
Biology
Xiaoqian Cheng, Kenan Rajjoub, Alexey Shashurin, Dayun Yan, Jonathan H. Sherman, Ka Bian, Ferid Murad, Michael Keidar
BIOELECTROMAGNETICS
(2017)
Article
Physics, Applied
Zhitong Chen, Xiaoqian Cheng, Li Lin, Michael Keidar
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2017)
Article
Physics, Applied
Zhitong Chen, Li Lin, Xiaoqian Cheng, Eda Gjika, Michael Keidar
PLASMA PROCESSES AND POLYMERS
(2016)
Article
Biophysics
Zhitong Chen, Li Lin, Xiaoqian Cheng, Eda Gjika, Michael Keidar
Article
Oncology
Zhitong Chen, Hayk Simonyan, Xiaoqian Cheng, Eda Gjika, Li Lin, Jerome Canady, Jonathan H. Sherman, Colin Young, Michael Keidar
Article
Chemistry, Physical
Xiuqi Fang, Xiaoqian Cheng, Yuerou Zhang, Lijie Grace Zhang, Michael Keidar
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2018)
Article
Multidisciplinary Sciences
Alan Siu, Olga Volotskova, Xiaoqian Cheng, Siri S. Khalsa, Ka Bian, Ferid Murad, Michael Keidar, Jonathan H. Sherman
Article
Multidisciplinary Sciences
Dayun Yan, Annie Talbot, Niki Nourmohammadi, Xiaoqian Cheng, Jerome Canady, Jonathan Sherman, Michael Keidar
SCIENTIFIC REPORTS
(2015)
Article
Biochemistry & Molecular Biology
Xiaoqian Cheng, Saravana R. K. Murthy, Taisen Zhuang, Lawan Ly, Olivia Jones, Giacomo Basadonna, Michael Keidar, Yasmine Kanaan, Jerome Canady
Summary: Cold atmospheric plasma treatment affects breast cancer cells by inhibiting cell proliferation, inducing apoptosis, and disrupting the cell cycle, leading to cancer cell death through oxidation and degradation of histone mRNA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Annisa Elbedour, Xiaoqian Cheng, Saravana R. K. Murthy, Taisen Zhuang, Lawan Ly, Olivia Jones, Giacomo Basadonna, Michael Keidar, Jerome Canady
Summary: Cold atmospheric plasma (CAP) is a promising tool in modern medicine with potential applications in oncology, regenerative medicine, and immunotherapy. This study investigates the causal relationships between intracellular reactive oxygen species (ROS), caspase activity, Ki-67 expression, G1 activity, and cell proliferation and death after Canady Helios Cold Plasma (CHCP) treatment. The results show that there is a Granger causal relationship between all variables after 5 mins CHCP treatment, but not all variables are causal in the 3 mins models. Causal modeling is needed to optimize the application of cold plasma in cancer treatment.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Lawan Ly, Xiaoqian Cheng, Saravana R. K. Murthy, Olivia Z. Jones, Taisen Zhuang, Steven Gitelis, Alan T. Blank, Aviram Nissan, Mohammad Adileh, Matthew Colman, Michael Keidar, Giacomo Basadonna, Jerome Canady
Summary: This study evaluates the efficacy of cold atmospheric plasma (CAP) in multiple soft tissue sarcoma (STS) cell lines, and the results show that CAP treatment reduces the viability of STS cells by inhibiting proliferation, disrupting cell cycle, and inducing apoptosis-like cell death.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhitong Chen, Li Lin, Eda Gjika, Xiaoqian Cheng, Jerome Canady, Michael Keidar
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2018)
Meeting Abstract
Biochemistry & Molecular Biology
Hayk Simonyan, Zhitong Chen, Jonathan Sherman, Xiaoqian Cheng, Michael Keidar, Colin N. Young
