Journal
JOURNAL OF PHYSICS D-APPLIED PHYSICS
Volume 50, Issue 1, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1361-6463/50/1/015208
Keywords
cold atmospheric plasma; underwater plasma; cancer therapy
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Funding
- National Science Foundation [1465061]
- Department of Biochemistry and Molecular Medicine at George Washington University
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Cold atmospheric plasma (CAP) has emerged as a novel technology for cancer treatment. CAP can directly treat cells and tissue but such direct application is limited to skin or can be invoked as a supplement during open surgery. In this study we report indirect plasma treatment using CAP discharged in deionized (DI) water using three gases as carriers (argon (Ar), helium (He), and nitrogen (N-2)). Plasma stimulated water was applied to the human breast cancer cell line (MDA-MB-231). MTT (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay tests showed that using Ar plasma had the strongest effect on inducing apoptosis in cultured human breast cancer cells. This result is attributed to the elevated production of reactive oxygen species and reactive nitrogen species in water.
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