Article
Oncology
Xiaoting Zhang, Xiaofeng Li, Xian Fu, Mengli Yu, Guicheng Qin, Guihong Chen, Chenchen Huang
Summary: Bladder cancer (BCa) is the most common malignant tumor of the urinary system. Circular RNA TAF4B (circTAF4B) was identified as significantly upregulated in BCa and correlated with poor prognosis. Downregulation of circTAF4B inhibited growth, metastasis, and the EMT process in BCa cells by sponging miR-1298-5p to facilitate the expression of transforming growth factor A (TGFA). CircTAF4B may be a diagnostic and therapeutic target for BCa.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jie Zhang, Chenyang Hu, Dawei Hu, Zhimin Fan
Summary: miR-1298-5p exhibits tumor-suppressive functions in breast cancer by inhibiting cell proliferation, adhesion, and migration while promoting apoptosis through downregulation of E2F1.
Article
Medicine, Research & Experimental
Xuan He, He Xiao, Rui Yang, Hang Chen, Bin Wang
Summary: This study identified LOC339524 as a suppressor of cell proliferation in bladder cancer, possibly by regulating the miR-875-5p/COPS7A signaling axis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ke Li
Summary: This study revealed that miR-509-3-5p regulates the malignancy of colon cancer by suppressing target gene GTSE1. Downregulation of miR-509-3-5p in CC and its overexpression can inhibit the proliferation, migration, and invasion of CC cells. MiR-509-3-5p targets GTSE1, identified as an oncogene in colon cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Hao Lin, Xiaojun Shi, Haoran Li, Jialiang Hui, Ruiyu Liu, Zihao Chen, Yuwen Lu, Wanlong Tan
Summary: The study identified miR-93-5p and miR-516a-5p in urinary exosomes as potential biomarkers for bladder cancer detection, showing promising diagnostic value in BC patients. Further validation demonstrated that the expression level of miR-93-5p was associated with the progression of bladder cancer.
Article
Biotechnology & Applied Microbiology
RongXin Xiao, Hong Wang, Biao Yang
Summary: The study showed that overexpression of miR-98-5p can inhibit the growth and spread of cervical cancer cells, and promote cell apoptosis, making it a potential target for future research in treating cervical cancer.
Article
Cell Biology
Yuan Chen, Shiben Ji, Jianxin Ying, Yongchang Sun, Jun Liu, Guohong Yin
Summary: This study identifies a novel biomarker, KRT6A, for early diagnosis of bladder tumors and reveals its role in promoting bladder tumor progression. Additionally, it uncovers the regulatory axis of KRT6A/miR-31-5p in bladder tumor growth.
Article
Medicine, General & Internal
Zhuo Gao, Jannan Jiang, Lijian Hou, Bin Zhang
Summary: This study reveals the upregulation of RNF187 in colorectal cancer (CRC) and its association with poor prognosis. Inhibition of RNF187 expression suppresses the proliferation, migration, and invasion while promoting apoptosis of CRC cells. miR-144-5p is identified as a direct target of RNF187, and its downregulation in CRC tissues is negatively correlated with RNF187 expression. Restoration of miR-144-5p significantly inhibits CRC cell progression, which can be abolished by overexpression of RNF187.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Wei Zeng, Li Fu, Hongfang Xu
Summary: Research has shown that radiation therapy may alleviate neuroinflammation by regulating miR-206 to target Cx43; this could offer a novel avenue for clinical treatment of inflammation-associated neuronal injury post-irradiation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Yan-Jun Zong, Xiao-Zhou Liu, Lei Tu, Yu Sun
Summary: This review discusses the contribution of the connexin gene family to hearing loss, focusing on the GJB2, GJB6, and GJA1 genes. Mutations in these genes can lead to comprehensive or non-comprehensive genetic deafness in newborns. The precise regulation of connexin biosynthesis, structural composition, and degradation is crucial for proper functioning of gap junctions. This review provides insights into the etiological principles of connexin mutations and offers potential therapeutic strategies for hereditary deafness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jian Ma, Li-Yun Xu, Qiu-Hong Sun, Xiao-Yu Wan, BingLi
Summary: Sepsis is a major cause of morbidity and mortality, with acute lung injury being a significant complication. Research on exosomal miRNAs in sepsis and sepsis lung injury is limited, but a study found that miR-1298-5p in exosomes from sepsis lung injury patients targeted SOCS6 via the STAT3 pathway, leading to increased cell permeability and inflammation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Ruliang Ding, Weiwen Hong, Liang Huang, Jinfan Shao, Wenfeng Yu, Xijuan Xu
Summary: MicroRNA-145-5p represses colon cancer cell cycle progression and cell proliferation by targeting PSAT1.
Article
Biotechnology & Applied Microbiology
Xiaoling Geng, Haoyu Wang, Lichen Xu, Yazhou Han, Yadong Liu
Summary: In osteosarcoma patients, plasma levels of microRNA-140-5p were significantly lower while plasma levels of GLUT-1 were significantly higher compared to healthy controls. The plasma levels of microRNA-140-5p were negatively correlated with GLUT-1 levels in osteosarcoma patients. The overexpression of microRNA-140-5p inhibited cancer cell proliferation, while the overexpression of GLUT-1 promoted cancer cell proliferation.
ONCOTARGETS AND THERAPY
(2021)
Article
Medicine, General & Internal
Edyta M. Borkowska, Piotr Kutwin, Dorota Rolecka, Tomasz Konecki, Maciej Borowiec, Zbigniew Jablonowski
Summary: The study aimed to evaluate the clinical utility of miR-19a-3p and miR-99a-5p as diagnostic markers in non-invasive bladder cancer. Real-time PCR was used to assess the expression of microRNA. The results showed that miR-19a-3p and miR-99a-5p were significantly altered in bladder cancer samples and could serve as diagnostic markers.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Oncology
Guanghui Cao, Chan Zhang, Xiangyong Tian, Gaopeng Jing, Xiaolin Zhou, Tianzhong Yan
Summary: The study found that circCEP128 is highly expressed in bladder cancer, and its knockdown can inhibit the proliferation, migration, and invasion of bladder cancer cells while promoting apoptosis. circCEP128 restrains the malignant progression of bladder cancer by regulating the miR-515-5p/SDC1 axis.
CANCER MANAGEMENT AND RESEARCH
(2021)