Article
Oncology
Hao Lin, Xiaojun Shi, Haoran Li, Jialiang Hui, Ruiyu Liu, Zihao Chen, Yuwen Lu, Wanlong Tan
Summary: The study identified miR-93-5p and miR-516a-5p in urinary exosomes as potential biomarkers for bladder cancer detection, showing promising diagnostic value in BC patients. Further validation demonstrated that the expression level of miR-93-5p was associated with the progression of bladder cancer.
Article
Medicine, Research & Experimental
Liu-Jing Wen, Yue-Sheng Wang, Pei-Yi Tan
Summary: The study demonstrated that miR-515-5p inhibits breast cancer cell proliferation, migration, and invasion by directly targeting CBX4.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, General & Internal
Edyta M. Borkowska, Piotr Kutwin, Dorota Rolecka, Tomasz Konecki, Maciej Borowiec, Zbigniew Jablonowski
Summary: The study aimed to evaluate the clinical utility of miR-19a-3p and miR-99a-5p as diagnostic markers in non-invasive bladder cancer. Real-time PCR was used to assess the expression of microRNA. The results showed that miR-19a-3p and miR-99a-5p were significantly altered in bladder cancer samples and could serve as diagnostic markers.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Pengxu Shi, Yueting Li, Qingsheng Guo
Summary: The study identified the critical role of circular RNA circPIP5K1A in the stemness of osteosarcoma cells, with enhanced expression in clinical tissues. Knockdown of circPIP5K1A inhibited cell viabilities, induced apoptosis, and reduced invasion and migration capabilities. Mechanistically, circPIP5K1A enhanced YAP expression by targeting miR-515-5p, affecting the stemness of osteosarcoma cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Camila Meirelles S. Silva, Mateus C. Barros-Filho, Deysi Viviana T. Wong, Julia Bette H. Mello, Livia Maria S. Nobre, Carlos Wagner S. Wanderley, Larisse T. Lucetti, Heitor A. Muniz, Igor Kenned D. Paiva, Hellen Kuasne, Daniel Paula P. Ferreira, Maria Perpetuo S. S. Cunha, Carlos G. Hirth, Paulo Goberlanio B. Silva, Rosane O. Sant'Ana, Marcellus Henrique L. P. Souza, Josiane S. Quetz, Silvia R. Rogatto, Roberto Cesar P. Lima-Junior
Summary: By screening miRNAs in plasma, we identified four miRNAs as potential biomarkers for the early detection of colorectal cancer, presenting high performance and easy applicability in clinical practice.
Article
Oncology
Christos Miliotis, Frank J. Slack
Summary: In gastric cancer, miR-105-5p has been identified as a key regulator of PD-L1 expression, impacting T cell activation, and could serve as a potential biomarker and target for combination immunotherapy targeting PD-1/PD-L1 interactions.
Article
Genetics & Heredity
Damian Kolat, Zaneta Kaluzinska-Kolat, Katarzyna Kosla, Magdalena Orzechowska, Elzbieta Pluciennik, Andrzej K. Bednarek
Summary: This study aimed to construct an ncRNA-containing network with WWOX/AP-2 and investigate its relevance in bladder cancer cell lines and patients. Through high-throughput sequencing and various bioinformatics tools, a novel lncRNA/miRNA/mRNA axis involving LINC01137, WWOX, and miR-186-5p was discovered. Patient data confirmed the relationship between LINC01137, miR-186-5p, and WWOX, and provided a set of dependent genes. This study suggests that the WWOX-containing lncRNA/miRNA/mRNA axis may have implications for bladder cancer research and treatment.
FRONTIERS IN GENETICS
(2023)
Article
Cell Biology
Peng Wu, Chunxiang Li, Dong mei Ye, Kenan Yu, Yuxuan Li, Hailin Tang, Gaoshen Xu, Shuijing Yi, Zhiwei Zhan
Summary: In this study, circEPSTI1 was found to be significantly upregulated in cervical cancer and shown to impact cell ferroptosis. The circEPSTI1-miR-375/409-3P/515-5p-SLC7A11 axis was identified to affect proliferation in cervical cancer through the ceRNA mechanism and was linked to ferroptosis. The findings suggest circEPSTI1 as a potential new biomarker for monitoring and targeting treatment in cervical cancer.
Article
Medicine, Research & Experimental
Xuan He, He Xiao, Rui Yang, Hang Chen, Bin Wang
Summary: This study identified LOC339524 as a suppressor of cell proliferation in bladder cancer, possibly by regulating the miR-875-5p/COPS7A signaling axis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Guoliang Mao, Bing Zhou, Wuqin Xu, Nanlin Jiao, Zhihao Wu, Jiajia Li, Yinhua Liu
Summary: In CRC, circ_0040809 and DNMT1 expression are increased while miR-515-5p expression is decreased. circ_0040809 facilitates CRC cell proliferation and migration, and inhibits apoptosis through modulating the miR-515-5p/DNMT1 axis. Targeting circ_0040809 may be a potential therapeutic strategy for CRC treatment.
JOURNAL OF GENE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Aurora Eliana Merulla, Michele Stella, Cristina Barbagallo, Rosalia Battaglia, Angela Caponnetto, Giuseppe Broggi, Roberto Altieri, Francesco Certo, Rosario Caltabiano, Marco Ragusa, Giuseppe Maria Vincenzo Barbagallo, Cinzia Di Pietro, Michele Purrello, Davide Barbagallo
Summary: This study investigates the role of circSMARCA5 in controlling miRNAs 126-3p and 515-5p in GBM cells, revealing a new subnetwork regulated by circSMARCA5 which affects downstream mRNA targets IGFBP2 and NRAS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Kuang-Yu Chou, An-Chen Chang, Te-Fu Tsai, Yi-Chia Lin, Hung-En Chen, Chao-Yen Ho, Po-Chun Chen, Thomas I-Sheng Hwang
Summary: hsa-miR-34a plays a role in inhibiting cell migration and invasion in bladder cancer by silencing matrix metalloproteinase-2 (MMP-2) expression, thus interrupting MMP-2-mediated cell motility.
Article
Oncology
Z. Wen, G. Huang, Y. Lai, L. Xiao, X. Peng, K. Liu, C. Zhang, X. Chen, R. Li, X. Li, Y. Lai, L. Ni
Summary: This study successfully identified a diagnostic panel of serum miRNAs for early detection of bladder cancer, showing high sensitivity and specificity. The panel of three miRNAs represents a potential non-invasive method for early detection of BC.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Yi Du, Xudong Zhang, Hongwei Zhang, Yiding Chen, Shuying Zhu, Jinjun Shu, Hui Pan
Summary: Propofol has been found to significantly suppress the proliferation, migration, and invasion of bladder cancer cells in vitro, largely through the upregulation of miR-145-5p expression. Silencing the direct target of miR-145-5p, TOP2A, reversed the effects of propofol treatment in bladder cancer cells. Additionally, propofol was shown to suppress tumor xenograft growth, with partial attenuation by miR-145-5p knockdown.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Andrology
Guangwen Wang, Haiyang Zhao, Xiaohong Duan, Zhiqiang Ren
Summary: The abundance of circular RNA circ-PAPPA is increased in prostate cancer cells, leading to elevated malignant phenotypes by negatively regulating miR-515-5p and modulating the expression of FKBP1A.