Article
Biochemistry & Molecular Biology
Ke Li
Summary: This study revealed that miR-509-3-5p regulates the malignancy of colon cancer by suppressing target gene GTSE1. Downregulation of miR-509-3-5p in CC and its overexpression can inhibit the proliferation, migration, and invasion of CC cells. MiR-509-3-5p targets GTSE1, identified as an oncogene in colon cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Hao Lin, Xiaojun Shi, Haoran Li, Jialiang Hui, Ruiyu Liu, Zihao Chen, Yuwen Lu, Wanlong Tan
Summary: The study identified miR-93-5p and miR-516a-5p in urinary exosomes as potential biomarkers for bladder cancer detection, showing promising diagnostic value in BC patients. Further validation demonstrated that the expression level of miR-93-5p was associated with the progression of bladder cancer.
Article
Biochemistry & Molecular Biology
Wei Kang, Jinglin Zhang, Tingting Huang, Yuhang Zhou, Chi Chun Wong, Ronald C. K. Chan, Yujuan Dong, Feng Wu, Bin Zhang, William K. K. Wu, Michael W. Y. Chan, Alfred S. L. Cheng, Jun Yu, Nathalie Wong, Kwok Wai Lo, Ka Fai To
Summary: Aberrant activation of NOTCH3 has been linked to poor clinical outcomes in gastric cancer, partially attributed to the silencing of tumor suppressor miRNAs miR-491-5p and miR-875-5p. PHLDB2 was identified as a functional downstream modulator of NOTCH3 in gastric carcinogenesis, with positive correlation with NOTCH3 and negative correlation with miR-491-5p. The NOTCH3-PHLDB2-Akt cascade acts oncogenically in gastric carcinogenesis and may serve as a potential therapeutic target.
Article
Biotechnology & Applied Microbiology
RongXin Xiao, Hong Wang, Biao Yang
Summary: The study showed that overexpression of miR-98-5p can inhibit the growth and spread of cervical cancer cells, and promote cell apoptosis, making it a potential target for future research in treating cervical cancer.
Article
Cell Biology
Yuan Chen, Shiben Ji, Jianxin Ying, Yongchang Sun, Jun Liu, Guohong Yin
Summary: This study identifies a novel biomarker, KRT6A, for early diagnosis of bladder tumors and reveals its role in promoting bladder tumor progression. Additionally, it uncovers the regulatory axis of KRT6A/miR-31-5p in bladder tumor growth.
Article
Medicine, General & Internal
Zhuo Gao, Jannan Jiang, Lijian Hou, Bin Zhang
Summary: This study reveals the upregulation of RNF187 in colorectal cancer (CRC) and its association with poor prognosis. Inhibition of RNF187 expression suppresses the proliferation, migration, and invasion while promoting apoptosis of CRC cells. miR-144-5p is identified as a direct target of RNF187, and its downregulation in CRC tissues is negatively correlated with RNF187 expression. Restoration of miR-144-5p significantly inhibits CRC cell progression, which can be abolished by overexpression of RNF187.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Ruliang Ding, Weiwen Hong, Liang Huang, Jinfan Shao, Wenfeng Yu, Xijuan Xu
Summary: MicroRNA-145-5p represses colon cancer cell cycle progression and cell proliferation by targeting PSAT1.
Article
Biotechnology & Applied Microbiology
Xiaoling Geng, Haoyu Wang, Lichen Xu, Yazhou Han, Yadong Liu
Summary: In osteosarcoma patients, plasma levels of microRNA-140-5p were significantly lower while plasma levels of GLUT-1 were significantly higher compared to healthy controls. The plasma levels of microRNA-140-5p were negatively correlated with GLUT-1 levels in osteosarcoma patients. The overexpression of microRNA-140-5p inhibited cancer cell proliferation, while the overexpression of GLUT-1 promoted cancer cell proliferation.
ONCOTARGETS AND THERAPY
(2021)
Article
Medicine, General & Internal
Edyta M. Borkowska, Piotr Kutwin, Dorota Rolecka, Tomasz Konecki, Maciej Borowiec, Zbigniew Jablonowski
Summary: The study aimed to evaluate the clinical utility of miR-19a-3p and miR-99a-5p as diagnostic markers in non-invasive bladder cancer. Real-time PCR was used to assess the expression of microRNA. The results showed that miR-19a-3p and miR-99a-5p were significantly altered in bladder cancer samples and could serve as diagnostic markers.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Oncology
Guanghui Cao, Chan Zhang, Xiangyong Tian, Gaopeng Jing, Xiaolin Zhou, Tianzhong Yan
Summary: The study found that circCEP128 is highly expressed in bladder cancer, and its knockdown can inhibit the proliferation, migration, and invasion of bladder cancer cells while promoting apoptosis. circCEP128 restrains the malignant progression of bladder cancer by regulating the miR-515-5p/SDC1 axis.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Reproductive Biology
Yinling Zhao, Donglan Yuan, Dandan Zhu, Tianhui Xu, Aihua Huang, Li Jiang, Chiwen Liu, Hua Qian, Xinhua Bu
Summary: In this study, it was found that MSC-AS1 and miR-425-5p were aberrantly expressed in ovarian cancer, with MSC-AS1 inhibiting ovarian cancer progression by modulating the levels of miR-425-5p. These findings may provide a promising therapeutic target for the treatment of ovarian cancer.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Xu Zhang, Hao Xiong, Yong Zhao, Shengqiang Lin, Xiang Huang, Cheng Lin, Shihui Mao, Demin Chen
Summary: This research identifies the circLONP2/miR-584-5p/YAP1 axis as a novel regulatory module in the progression of bladder cancer. The study shows that circLONP2 plays an oncogenic role by regulating the miR-584-5p/YAP1 axis, and targeting this interaction could be a potential strategy for treating bladder cancer.
Article
Oncology
Yongbao Wei, Zhensheng Chen, Ruochen Zhang, Bangkui Wu, Le Lin, Qingguo Zhu, Liefu Ye, Tao Li, Feng Li
Summary: This study investigated the role of circulating exosomal microRNA-423-5p in the progression of prostate cancer (PCa) and its molecular mechanism. The findings showed that microRNA-423-5p was highly expressed in PCa peripheral blood samples and its expression in serum exosomes of PCa patients was significantly higher than healthy individuals. Overexpression of microRNA-423-5p was found to promote the progression of PCa cells. Further analysis revealed that microRNA-423-5p targeted FRMD3 and down-regulated its expression. Exosomes carrying microRNA-423-5p could internalize into PCa cells and enhance cell proliferation, migration, and invasion in vivo.
Article
Oncology
Songbo Fu, Songquan Fu, Xiaoni Ma, Xiaomei Yang, Jizu Ling
Summary: The study revealed that miR-875-5p levels were reduced while TXNRD1 levels were increased in GDM rats compared to normal pregnancy rats. miR-875-5p regulates insulin resistance and inflammation by targeting TXNRD1, suggesting they may serve as potential therapeutic targets for GDM.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Multidisciplinary Sciences
Xiangke Cao, Qinghua Ma, Bin Wang, Qingqiang Qian, Yinan Xi
Summary: Circ-E2F3 is upregulated in cervical cancer tissues and cell lines, correlating with clinicopathological features and poor prognosis of patients. It promotes proliferation, invasion, migration of cancer cells, and tumor growth in vivo, by inhibiting miR-296-5p to facilitate nuclear translocation of STAT3 and affect cyclin D1 expression.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Oncology
Bin Wang, Shu Chen, He Xiao, Jiao Zhang, Dandan Liang, Jinlu Shan, Hua Zou
Summary: In this study, clinical risk factors for tumor metastasis in lung cancer patients were retrospectively analyzed, revealing age and PLT level as independent risk factors for bone metastasis and distal metastasis. The RB1 gene mutation was significantly associated with bone metastasis.
Article
Biochemistry & Molecular Biology
Rui Yang, Hang Chen, Lei Xing, Bin Wang, Mengting Hu, Xiaoqiang Ou, Hong Chen, Yumei Deng, Dawei Liu, Rong Jiang, Junxia Chen
Summary: This study identified a novel hypoxia-responsive circRNA named circWSB1, which could interact with USP10 and promote the progression of BC. It may serve as a prognostic biomarker and therapeutic target for BC patients.
Article
Cell Biology
Bin Wang, He Xiao, Xin Yang, Ying Zeng, Zhimin Zhang, Rui Yang, Hang Chen, Chuan Chen, Junxia Chen
Summary: Immune microenvironment and microRNAs have important predictive roles in tumor prognosis. This study presents a novel immune-related microRNA signature for assessing the prognosis of thymoma.