Mangiferin: A xanthonoid with multipotent anti-inflammatory potential

Protective effects of mangiferin on cerebral ischemia–reperfusion injury and its mechanisms

(2016) Zhang Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mangiferin alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

(2016) Chen-wei Pan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Morin protects gastric mucosa from nonsteroidal anti-inflammatory drug, indomethacin induced inflammatory damage and apoptosis by modulating NF-κB pathway

(2015) Krishnendu Sinha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mangiferin Inhibits Renal Urate Reabsorption by Modulating Urate Transporters in Experimental Hyperuricemia

(2015) Hua Yang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Protective effect of polyphenols in an inflammatory process associated with experimental pulmonary fibrosis in mice

(2015) Daniela Impellizzeri et al.   BRITISH JOURNAL OF NUTRITION

Cytochrome P450s: Mechanisms and Biological Implications in Drug Metabolism and its Interaction with Oxidative Stress

(2015) Sudip Bhattacharyya et al.   CURRENT DRUG METABOLISM

Mango Polyphenols and Its Protective Effects on Diseases Associated to Oxidative Stress

(2015) Alberto Selles et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

A natural xanthone increases catalase activity but decreases NF-kappa B and lipid peroxidation in U-937 and HepG2 cell lines

(2015) Binay K. Sahoo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

(2015) Shatadal Ghosh et al.   FOOD AND CHEMICAL TOXICOLOGY

Mangiferin attenuates renal ischemia-reperfusion injury by inhibiting inflammation and inducing adenosine production

(2015) Bin Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Identification of Target Proteins of Mangiferin in Mice with Acute Lung Injury Using Functionalized Magnetic Microspheres Based on Click Chemistry

(2015) Jiajia Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In vitro studies on mangiferin protection against cadmium-induced human renal endothelial damage and cell death via the MAP kinase and NF-κB pathways

(2015) Peramaiyan Rajendran et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Mangiferin ameliorates aluminium chloride-induced cognitive dysfunction via alleviation of hippocampal oxido-nitrosative stress, proinflammatory cytokines and acetylcholinesterase level

(2015) Prajapati Kasbe et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Medicinal Properties of Mangiferin, Structural Features, Derivative Synthesis, Pharmacokinetics and Biological Activities

(2015) Outhiriaradjou Benard et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Modulation of Diabetes and Dyslipidemia in Diabetic Insulin-Resistant Rats by Mangiferin: Role of Adiponectin and TNF-α

(2015) SAMIRA SALEH et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Comparative Pharmacokinetic Study of Mangiferin After Oral Administration of Pure Mangiferin and US Patented Polyherbal Formulation to Rats

(2014) Ananth Kumar Kammalla et al.   AAPS PHARMSCITECH

Mangiferin Attenuate Sepsis-Induced Acute Kidney Injury via Antioxidant and Anti-Inflammatory Effects

(2014) Liyu He et al.   AMERICAN JOURNAL OF NEPHROLOGY

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Evidence of oxidative stress and mitochondrial respiratory chain dysfunction in an in vitro model of sepsis-induced kidney injury

(2014) C. Quoilin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Beneficial properties of natural phenols: Highlight on protection against pathological conditions associated with amyloid aggregation

(2014) Massimo Stefani et al.   BIOFACTORS

Mangiferin Regulates Interleukin-6 and Cystathionine-b-Synthase in Lipopolysaccharide-Induced Brain Injury

(2014) Yan-Yan Fu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mangiferin Stimulates Carbohydrate Oxidation and Protects Against Metabolic Disorders Induced by High-Fat Diets

(2014) Pasha Apontes et al.   DIABETES

Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-κB and MAPK pathways

(2014) Jin-Ju Jeong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice

(2014) Ashok Jangra et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation

(2014) Wei Dou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Advanced Glycation End Products Induce Lipogenesis: Regulation by Natural Xanthone through Inhibition of ERK and NF-κB

(2014) Sidhartha K. Mahali et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mangiferin in cancer chemoprevention and treatment: pharmacokinetics and molecular targets

(2014) Peramaiyan Rajendran et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Mangiferin: A promising therapeutic agent for rheumatoid arthritis treatment

(2014) P. Luczkiewicz et al.   MEDICAL HYPOTHESES

Genistein: A Phytoestrogen with Multifaceted Therapeutic Properties

(2014) Sukanya Saha et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Dual Mode Action of Mangiferin in Mouse Liver under High Fat Diet

(2014) Jihyeon Lim et al.   PLoS One

Mangiferin Attenuates Diabetic Nephropathy by Inhibiting Oxidative Stress Mediated Signaling Cascade, TNFα Related and Mitochondrial Dependent Apoptotic Pathways in Streptozotocin-Induced Diabetic Rats

(2014) Pabitra Bikash Pal et al.   PLoS One

Mangiferin treatment inhibits hepatic expression of acyl-coenzyme A:diacylglycerol acyltransferase-2 in fructose-fed spontaneously hypertensive rats: a link to amelioration of fatty liver

(2014) Xiaomang Xing et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Resources and Biological Activities of Natural Polyphenols

(2014) An-Na Li et al.   Nutrients

Arjunolic acid: A new multifunctional therapeutic promise of alternative medicine

(2013) Jyotirmoy Ghosh et al.   BIOCHIMIE

Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson’s disease mice

(2013) Mani Kavitha et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Therapeutic and cosmetic applications of mangiferin: a patent review

(2013) Manasi Telang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

An update on oxidative stress-mediated organ pathophysiology

(2013) Kahkashan Rashid et al.   FOOD AND CHEMICAL TOXICOLOGY

Norathyriol suppresses transformation in JB6 P+ cells by the inhibition of Akt

(2013) Jixia Li et al.   Journal of Cancer Research and Therapeutics

Role of Nrf2 in protection against acute kidney injury

(2013) Luke M. Shelton et al.   KIDNEY INTERNATIONAL

Mangiferin, a Natural Xanthone, Protects Murine Liver in Pb(II) Induced Hepatic Damage and Cell Death via MAP Kinase, NF-κB and Mitochondria Dependent Pathways

(2013) Pabitra Bikash Pal et al.   PLoS One

Mangiferin Prevents Guinea Pig Tracheal Contraction via Activation of the Nitric Oxide-Cyclic GMP Pathway

(2013) Aline B. Vieira et al.   PLoS One

Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats

(2013) Yao-Wu Liu et al.   PSYCHOPHARMACOLOGY

Mangiferin exerts antitumor activity in breast cancer cells by regulating matrix metalloproteinases, epithelial to mesenchymal transition, and β-catenin signaling pathway

(2013) Hongzhong Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hypericin-photodynamic therapy leads to interleukin-6 secretion by HepG2 cells and their apoptosis via recruitment of BH3 interacting-domain death agonist and caspases

(2013) M Barathan et al.   Cell Death & Disease

Standardized butanol fraction of WIN-34B suppresses cartilage destruction via inhibited production of matrix metalloproteinase and inflammatory mediator in osteoarthritis human cartilage explants culture and chondrocytes

(2012) Jeong-Eun Huh et al.   BMC Complementary and Alternative Medicine

Evaluation of genotoxicity and DNA protective effects of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark extract

(2012) I. Rodeiro et al.   FOOD AND CHEMICAL TOXICOLOGY

Cancer Control in the Asia Pacific Region: Current Status and Concerns

(2012) H.-R. Shin et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1

(2012) Xia Gong et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Perspectives on Medicinal Properties of Mangiferin

(2012) A. Vyas et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Mangiferin Decreases Plasma Free Fatty Acids through Promoting Its Catabolism in Liver by Activation of AMPK

(2012) Yucun Niu et al.   PLoS One

Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2–NFκB pathways

(2012) Joydeep Das et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells

(2011) Kaori Shoji et al.   ARCHIVES OF PHARMACAL RESEARCH

Multifaceted link between cancer and inflammation

(2011) Gautam Sethi et al.   BIOSCIENCE REPORTS

Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells

(2011) Dagmar García-Rivera et al.   CANCER LETTERS

Mangiferin decreases inflammation and oxidative damage in rat brain after stress

(2011) Lucía Márquez et al.   EUROPEAN JOURNAL OF NUTRITION

D(+) galactosamine induced oxidative and nitrosative stress-mediated renal damage in rats via NF-κB and inducible nitric oxide synthase (iNOS) pathways is ameliorated by a polyphenol xanthone, mangiferin

(2011) Manoranjan Ghosh et al.   FREE RADICAL RESEARCH

Structure elucidation of in vivo and in vitro metabolites of mangiferin

(2011) Huihui Liu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Characterization and determination of the major constituents in Belamcandae Rhizoma by HPLC–DAD–ESI-MSn

(2011) Yuan-Yuan Zhang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Mangifera indicaL. extract (Vimang) and mangiferin reduce the airway inflammation and Th2 cytokines in murine model of allergic asthma

(2011) Dagmar García Rivera et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Photoprotection by honeybush extracts, hesperidin and mangiferin against UVB-induced skin damage in SKH-1 mice

(2011) Antoinette Petrova et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Sepsis and Acute Kidney Injury

(2011) A. Zarjou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters

(2011) Fuchuan Guo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cognition boosting effect of Canscora decussata (a South Indian Shankhpushpi)

(2011) Neeraj K. Sethiya et al.   European Journal of Integrative Medicine

Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action

(2011) David Vauzour et al.   Nutrients

Biological Factors Influencing Production of Xanthones inAphloia theiformis

(2010) Pascal Danthu et al.   CHEMISTRY & BIODIVERSITY

Diabetes is an inflammatory disease: evidence from traditional Chinese medicines

(2010) W. Xie et al.   DIABETES OBESITY & METABOLISM

Mangiferin, a naturally occurring glucoxilxanthone improves long-term object recognition memory in rats

(2010) Gilberto L. Pardo Andreu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

New and Known Constituents from Iris unguicularis and Their Antioxidant Activity

(2010) _ Atta-ur-Rahman et al.   HETEROCYCLES

Antigenotoxic effect of mangiferin and changes in antioxidant enzyme levels of Swiss albino mice treated with cadmium chloride

(2010) E. Kasi Viswanadh et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Liver diseases associated with anti-tumor necrosis factor-alpha (TNF-α) use for inflammatory bowel disease

(2010) Carla S. Coffin et al.   INFLAMMATORY BOWEL DISEASES

The Apolipoprotein E-Mimetic Peptide COG112 Inhibits NF-κB Signaling, Proinflammatory Cytokine Expression, and Disease Activity in Murine Models of Colitis

(2010) Kshipra Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extraction of mangiferin from Mahkota Dewa (Phaleria macrocarpa) using subcritical water

(2010) Wan-Joo Kim et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

14-3-3 Epsilon Dynamically Interacts with Key Components of Mitogen-Activated Protein Kinase Signal Module for Selective Modulation of the TNF-α-Induced Time Course-Dependent NF-κB Activity

(2010) Shuai Zuo et al.   JOURNAL OF PROTEOME RESEARCH

Bioactive xanthones from the roots of Hypericum perforatum (common St John's wort)

(2010) Sara L Crockett et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

A Mangifera indica L. Extract Could Be Used to Treat Neuropathic Pain and Implication of Mangiferin

(2010) Bárbara B. Garrido-Suárez et al.   MOLECULES

Radioprotective activity of Gentiana lutea extract and mangiferin

(2010) Nebojsa Menkovic et al.   PHYTOTHERAPY RESEARCH

Prevention of tertiary butyl hydroperoxide induced oxidative impairment and cell death by a novel antioxidant protein molecule isolated from the herb, Phyllanthus niruri

(2010) Mrinal K. Sarkar et al.   TOXICOLOGY IN VITRO

Molecular mechanisms of neuroprotection by two natural antioxidant polyphenols

(2009) María Rosario Campos-Esparza et al.   CELL CALCIUM

Arsenic-induced oxidative cerebral disorders: Protection by taurine

(2009) Joydeep Das et al.   DRUG AND CHEMICAL TOXICOLOGY

Preparative isolation of neomangiferin and mangiferin fromRhizoma anemarrhenaeby high-speed countercurrent chromatography using ionic liquids as a two-phase solvent system modifier

(2009) Lili Xu et al.   JOURNAL OF SEPARATION SCIENCE

Mangifera indica L. extract attenuates glutamate-induced neurotoxicity on rat cortical neurons

(2009) Yeny Lemus-Molina et al.   NEUROTOXICOLOGY

Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice

(2009) Bomi Lee et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Mechanism of protective action of mangiferin on suppression of inflammatory response and lysosomal instability in rat model of myocardial infarction

(2009) S. Prabhu et al.   PHYTOTHERAPY RESEARCH

Mangiferin Inhibits Passive Cutaneous Anaphylaxis Reaction and Pruritus in Mice

(2009) Bomi Lee et al.   PLANTA MEDICA

Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells

(2008) Harsharan S. Bhatia et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Effect of mangiferin on the development of periodontal disease: Involvement of lipoxin A4, anti-chemotaxic action in leukocyte rolling

(2008) Roney Rick Carvalho et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Major Mango Polyphenols and Their Potential Significance to Human Health

(2008) Martin Masibo et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes

(2008) J. M. Forbes et al.   DIABETES

Effects of the Mango Components Mangiferin and Quercetin and the Putative Mangiferin Metabolite Norathyriol on the Transactivation of Peroxisome Proliferator-Activated Receptor Isoforms

(2008) Ashley S. Wilkinson et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Characterization and Quantitation of Polyphenolic Compounds in Bark, Kernel, Leaves, and Peel of Mango (Mangifera indicaL.)

(2008) Jacqueline C. Barreto et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Characterization of the mangiferin–human serum albumin complex by spectroscopic and molecular modeling approaches

(2008) Yuanyuan Yue et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Effect of mangiferin on benzo(a)pyrene induced lung carcinogenesis in experimental Swiss albino mice

(2008) P. Rajendran et al.   NATURAL PRODUCT RESEARCH

Ischemia/Reperfusion Injury in Kidney Transplantation: Mechanisms and Prevention

(2008) M. Kosieradzki et al.   TRANSPLANTATION PROCEEDINGS