RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives

Intrathecal RGS4 Inhibitor, CCG50014, Reduces Nociceptive Responses and Enhances Opioid-Mediated Analgesic Effects in the Mouse Formalin Test

(2015) Seo-Yeon Yoon et al.   ANESTHESIA AND ANALGESIA

Regulator of G-protein signalling 5 protects against atherosclerosis in apolipoprotein E-deficient mice

(2015) Wen-Lin Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

RGS2 and RGS4 proteins: New modulators of the κ-opioid receptor signaling

(2015) Maria-Pagona Papakonstantinou et al.   CELLULAR SIGNALLING

An Essential Role for RGS Protein/Gαi2Interactions in B Lymphocyte–Directed Cell Migration and Trafficking

(2015) Il-Young Hwang et al.   JOURNAL OF IMMUNOLOGY

RGS4 inhibits angiotensin II signaling and macrophage localization during renal reperfusion injury independent of vasospasm

(2015) Paul Pang et al.   KIDNEY INTERNATIONAL

Epidemiology of inflammatory bowel disease: Focus on Asia

(2014) Siew C. Ng   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Novel orally available salvinorin A analog PR-38 protects against experimental colitis and reduces abdominal pain in mice by interaction with opioid and cannabinoid receptors

(2014) Maciej Sałaga et al.   BIOCHEMICAL PHARMACOLOGY

Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT1A receptor-adenylyl cyclase axis

(2014) Adele Stewart et al.   FASEB JOURNAL

Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH)

(2014) M. Sałaga et al.   Journal of Crohns & Colitis

RGS13 Controls G Protein-Coupled Receptor-Evoked Responses of Human Mast Cells

(2014) G. Bansal et al.   JOURNAL OF IMMUNOLOGY

Vagal anandamide signaling via cannabinoid receptor 1 contributes to luminal 5-HT modulation of visceral nociception in rats

(2014) Chen-Chen Feng et al.   PAIN

Anti-inflammatory action of a novel orally available peptide 317 in mouse models of inflammatory bowel diseases

(2014) Marta Sobczak et al.   Pharmacological Reports

Vedolizumab for inflammatory bowel disease: Changing the game, or more of the same?

(2014) Tim Raine   United European Gastroenterology Journal

Effect of Ramosetron on Stool Consistency in Male Patients With Irritable Bowel Syndrome With Diarrhea

(2013) Shin Fukudo et al.   Clinical Gastroenterology and Hepatology

Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine

(2013) Kara Gross Margolis et al.   GUT

A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea

(2013) Klara Garsed et al.   GUT

RGS6, but Not RGS4, Is the Dominant Regulator of G Protein Signaling (RGS) Modulator of the Parasympathetic Regulation of Mouse Heart Rate

(2013) Nicole Wydeven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives

(2013) Marta Sobczak et al.   JOURNAL OF GASTROENTEROLOGY

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

(2013) Gary M. Mawe et al.   Nature Reviews Gastroenterology & Hepatology

Randomised clinical trial: alosetron improves quality of life and reduces restriction of daily activities in women with severe diarrhoea-predominant IBS

(2012) F. Cremonini et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A finer tuning of G-protein signaling through regulated control of RGS proteins

(2012) Jacob Kach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Brain-Gut Interactions in Inflammatory Bowel Disease

(2012) Bruno L. Bonaz et al.   GASTROENTEROLOGY

RGS16 Attenuates Pulmonary Th2/Th17 Inflammatory Responses

(2012) S. P. Shankar et al.   JOURNAL OF IMMUNOLOGY

The Loss of RGS Protein-G i2 Interactions Results in Markedly Impaired Mouse Neutrophil Trafficking to Inflammatory Sites

(2012) H. Cho et al.   MOLECULAR AND CELLULAR BIOLOGY

The Complex of G Protein Regulator RGS9-2 and G 5 Controls Sensitization and Signaling Kinetics of Type 5 Adenylyl Cyclase in the Striatum

(2012) K. Xie et al.   Science Signaling

RGS proteins in heart: brakes on the vagus

(2012) Adele Stewart   Frontiers in Physiology

Serotonin Activates Dendritic Cell Function in the Context of Gut Inflammation

(2011) Nan Li et al.   AMERICAN JOURNAL OF PATHOLOGY

A Nanomolar-Potency Small Molecule Inhibitor of Regulator of G-Protein Signaling Proteins

(2011) Levi L. Blazer et al.   BIOCHEMISTRY

Localization and Regulation of Fluorescently Labeled Delta Opioid Receptor, Expressed in Enteric Neurons of Mice

(2011) Daniel P. Poole et al.   GASTROENTEROLOGY

Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors*

(2011) Jakub Fichna et al.   INFLAMMATORY BOWEL DISEASES

Cutting Edge: Regulator of G Protein Signaling-1 Selectively Regulates Gut T Cell Trafficking and Colitic Potential

(2011) D. L. Gibbons et al.   JOURNAL OF IMMUNOLOGY

A Unique Role of RGS9-2 in the Striatum as a Positive or Negative Regulator of Opiate Analgesia

(2011) K. Psigfogeorgou et al.   JOURNAL OF NEUROSCIENCE

Impact of fusion to Gαi2and co-expression with RGS proteins on pharmacological properties of human cannabinoid receptors CB1R and CB2R

(2011) Sarah Sutor et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease

(2011) A Di Sabatino et al.   Mucosal Immunology

R7BP Modulates Opiate Analgesia and Tolerance but not Withdrawal

(2011) Dimitra Terzi et al.   NEUROPSYCHOPHARMACOLOGY

Regulators of G-Protein Signaling and Their G  Substrates: Promises and Challenges in Their Use as Drug Discovery Targets

(2011) A. J. Kimple et al.   PHARMACOLOGICAL REVIEWS

SUMO-SIM Interactions Regulate the Activity of RGSZ2 Proteins

(2011) Javier Garzón et al.   PLoS One

Gβ5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems

(2011) Keqiang Xie et al.   PSYCHOPHARMACOLOGY

Small Molecule Inhibitors of Regulators of G Protein Signaling (RGS) Proteins

(2011) Emma M. Turner et al.   ACS Medicinal Chemistry Letters

Non-canonical functions of RGS proteins

(2010) Nan Sethakorn et al.   CELLULAR SIGNALLING

RGS6/Gβ5 Complex Accelerates I KACh Gating Kinetics in Atrial Myocytes and Modulates Parasympathetic Regulation of Heart Rate

(2010) Ekaterina Posokhova et al.   CIRCULATION RESEARCH

RGS6, a Modulator of Parasympathetic Activation in Heart

(2010) Jianqi Yang et al.   CIRCULATION RESEARCH

Thinking Outside of the "RGS Box": New Approaches to Therapeutic Targeting of Regulators of G Protein Signaling

(2010) B. Sjogren et al.   MOLECULAR PHARMACOLOGY

Allosteric Inhibition of the Regulator of G Protein Signaling-G  Protein-Protein Interaction by CCG-4986

(2010) D. L. Roman et al.   MOLECULAR PHARMACOLOGY

Reversible, Allosteric Small-Molecule Inhibitors of Regulator of G Protein Signaling Proteins

(2010) L. L. Blazer et al.   MOLECULAR PHARMACOLOGY

Cannabinoids and the gut: New developments and emerging concepts

(2010) Angelo A. Izzo et al.   PHARMACOLOGY & THERAPEUTICS

RGS16 Is a Marker for Prognosis in Colorectal Cancer

(2009) Norikatsu Miyoshi et al.   ANNALS OF SURGICAL ONCOLOGY

Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate μ- and δ-opioid receptor signaling

(2009) Leonidas J. Leontiadis et al.   CELLULAR SIGNALLING

Serotonin Has a Key Role in Pathogenesis of Experimental Colitis

(2009) Jean–Eric Ghia et al.   GASTROENTEROLOGY

Cloning and characterization of rabbit Rgs4 promoter in gut smooth muscle

(2009) Fang Li et al.   GENE

Differential Modulation of μ- and δ-Opioid Receptor Agonists by Endogenous RGS4 Protein in SH-SY5Y Cells

(2009) Qin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Gα subtype dependent

(2009) Jeffery N. Talbot et al.   JOURNAL OF NEUROCHEMISTRY

A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen

(2009) Rebecca A Roof et al.   BMC Pharmacology & Toxicology

Interleukin-1β up-regulates RGS4 through the canonical IKK2/IκBα/NF-κB pathway in rabbit colonic smooth muscle

(2008) Wenhui Hu et al.   BIOCHEMICAL JOURNAL

RGS4 Regulates Parasympathetic Signaling and Heart Rate Control in the Sinoatrial Node

(2008) Carlo Cifelli et al.   CIRCULATION RESEARCH

Regulators of G-protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide

(2008) Sabine Riekenberg et al.   FEBS Journal

Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors

(2008) Martin A. Storr et al.   JOURNAL OF MOLECULAR MEDICINE-JMM