Vascular and inflammatory mineralocorticoid receptors in kidney disease

Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration

(2019) Min Zhao et al.   Nature Communications

Mineralocorticoid receptor antagonists and kidney diseases: pathophysiological basis

(2019) Jonatan Barrera-Chimal et al.   KIDNEY INTERNATIONAL

Emerging therapeutic strategies for transplantation-induced acute kidney injury: protecting the organelles and the vascular bed

(2019) Nicolas Melis et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Diet-Induced Obesity Promotes Kidney Endothelial Stiffening and Fibrosis Dependent on the Endothelial Mineralocorticoid Receptor

(2019) Annayya R. Aroor et al.   HYPERTENSION

Recent advances in acute kidney injury and its consequences and impact on chronic kidney disease

(2019) Anna Zuk et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

The Absence of Endothelial Sodium Channel α (αENaC) Reduces Renal Ischemia/Reperfusion Injury

(2019) Antoine Tarjus et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Short- and long-term administration of the non-steroidal mineralocorticoid receptor antagonist finerenone opposes metabolic syndrome-related cardio-renal dysfunction

(2018) Marianne Lachaux et al.   DIABETES OBESITY & METABOLISM

Smooth Muscle Cell–Mineralocorticoid Receptor as a Mediator of Cardiovascular Stiffness With AgingNovelty and Significance

(2018) Seung Kyum Kim et al.   HYPERTENSION

Epithelial Sodium Channel in Aldosterone-Induced Endothelium Stiffness and Aortic Dysfunction

(2018) Guanghong Jia et al.   HYPERTENSION

SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling

(2018) Jakob Voelkl et al.   JOURNAL OF CLINICAL INVESTIGATION

Mineralocorticoid receptor antagonism improves diastolic dysfunction in chronic kidney disease in mice

(2018) Benjamin Bonnard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling

(2018) Jonatan Barrera-Chimal et al.   KIDNEY INTERNATIONAL

Mineralocorticoid receptor antagonists in kidney transplantation: time to consider?

(2018) Sophie Girerd et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion

(2018) Krister Bamberg et al.   PLoS One

Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling

(2018) Aurelie Nguyen Dinh Cat et al.   Scientific Reports

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

(2018) Vincenzo Marzolla et al.   Jove-Journal of Visualized Experiments

Macrophage Mineralocorticoid Receptor Is a Pleiotropic Modulator of Myocardial Infarct Healing

(2018) Daniela Fraccarollo et al.   HYPERTENSION

Endothelial Mineralocorticoid Receptor Mediates Parenchymal Arteriole and Posterior Cerebral Artery Remodeling During Angiotensin II–Induced HypertensionNovelty and Significance

(2017) Janice M. Diaz-Otero et al.   HYPERTENSION

Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone Protects Against Acute Kidney Injury–Mediated Chronic Kidney DiseaseNovelty and Significance

(2017) Lionel Lattenist et al.   HYPERTENSION

Essential role of ICAM-1 in aldosterone-induced atherosclerosis

(2017) Vincenzo Marzolla et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1

(2017) Jonatan Barrera-Chimal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Novel Aldosterone Antagonist Limits Renal Injury in 5/6 Nephrectomy

(2017) Clarice K. Fujihara et al.   Scientific Reports

Deletion of the Mineralocorticoid Receptor in Myeloid Cells Attenuates Central Nervous System Autoimmunity

(2017) Elena Montes-Cobos et al.   Frontiers in Immunology

Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells

(2017) Ioana Alesutan et al.   Scientific Reports

Nanomechanics of the endothelial glycocalyx contribute to Na+-induced vascular inflammation

(2017) Florian Schierke et al.   Scientific Reports

MicroRNA-34b/c inhibits aldosterone-induced vascular smooth muscle cell calcification via a SATB2/Runx2 pathway

(2016) Jianbing Hao et al.   CELL AND TISSUE RESEARCH

Cardiac Tissue Injury and Remodeling Is Dependent Upon MR Regulation of Activation Pathways in Cardiac Tissue Macrophages

(2016) Jimmy Z. Shen et al.   ENDOCRINOLOGY

Vascular Smooth Muscle Mineralocorticoid Receptor Contributes to Coronary and Left Ventricular Dysfunction After Myocardial InfarctionNovelty and Significance

(2016) Alexandre Gueret et al.   HYPERTENSION

Re-Epithelialization of Pathological Cutaneous Wounds Is Improved by Local Mineralocorticoid Receptor Antagonism

(2016) Van Tuan Nguyen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Deletion of mineralocorticoid receptors in smooth muscle cells blunts renal vascular resistance following acute cyclosporine administration

(2016) Cristian A. Amador et al.   KIDNEY INTERNATIONAL

Deoxycorticosterone Acetate/Salt–Induced Cardiac But Not Renal Injury Is Mediated By Endothelial Mineralocorticoid Receptors Independently From Blood PressureNovelty and Significance

(2015) Achim Lother et al.   HYPERTENSION

Endothelial Mineralocorticoid Receptors Differentially Contribute to Coronary and Mesenteric Vascular Function Without Modulating Blood PressureNovelty and Significance

(2015) Katelee Barrett Mueller et al.   HYPERTENSION

Sulfenic Acid Modification of Endothelin B Receptor is Responsible for the Benefit of a Nonsteroidal Mineralocorticoid Receptor Antagonist in Renal Ischemia

(2015) J. Barrera-Chimal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling

(2015) Marcondes A. B. Silva et al.   Frontiers in Physiology

Endothelial Cell Mineralocorticoid Receptors Regulate Deoxycorticosterone/Salt-Mediated Cardiac Remodeling and Vascular Reactivity But Not Blood Pressure

(2014) Amanda J. Rickard et al.   HYPERTENSION

Spironolactone Decreases DOCA–Salt–Induced Organ Damage by Blocking the Activation of T Helper 17 and the Downregulation of Regulatory T Lymphocytes

(2014) Cristián A. Amador et al.   HYPERTENSION

Pretreatment with mineralocorticoid receptor blocker reduces intestinal injury induced by ischemia and reperfusion: involvement of inhibition of inflammatory response, oxidative stress, nuclear factor κB, and inducible nitric oxide synthase

(2014) Hale Sayan Ozacmak et al.   JOURNAL OF SURGICAL RESEARCH

Myeloid Mineralocorticoid Receptor Activation Contributes to Progressive Kidney Disease

(2014) L. L. Huang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Impact of Aldosterone on Osteoinductive Signaling and Vascular Calcification

(2014) Florian Lang et al.   NEPHRON PHYSIOLOGY

Myeloid Mineralocorticoid Receptor Deficiency Inhibits Aortic Constriction-Induced Cardiac Hypertrophy in Mice

(2014) Chao Li et al.   PLoS One

Smooth Muscle Cell Mineralocorticoid Receptors Are Mandatory for Aldosterone–Salt to Induce Vascular Stiffness

(2013) Guillaume Galmiche et al.   HYPERTENSION

Galectin-3 Mediates Aldosterone-Induced Vascular Fibrosis

(2012) Laurent Calvier et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Aldosterone Inactivates the Endothelin-B Receptor via a Cysteinyl Thiol Redox Switch to Decrease Pulmonary Endothelial Nitric Oxide Levels and Modulate Pulmonary Arterial Hypertension

(2012) Bradley A. Maron et al.   CIRCULATION

Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy

(2012) Min Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis

(2012) Danping Qin et al.   JOURNAL OF NEPHROLOGY

Spironolactone prevents chronic kidney disease caused by ischemic acute kidney injury

(2012) Jonatan Barrera-Chimal et al.   KIDNEY INTERNATIONAL

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors

(2012) Amy McCurley et al.   NATURE MEDICINE

Antihypertensive and Cardiorenal Protective Effects of SM-368229, a Novel Mineralocorticoid Receptor Antagonist, in Aldosterone/Salt-Treated Rats

(2012) Tetsuro Nariai et al.   PHARMACOLOGY

Aldosterone-Induced Fibrosis in the Kidney: Questions and Controversies

(2011) Andrew S. Brem et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Aldosterone Regulates Vascular Gene Transcription via Oxidative Stress–Dependent and –Independent Pathways

(2011) Brenna G. Newfell et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ménage à trois: Aldosterone, sodium and nitric oxide in vascular endothelium

(2010) Johannes Fels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

11β-Hydroxysteroid Dehydrogenase Type 2 Deficiency Accelerates Atherogenesis and Causes Proinflammatory Changes in the Endothelium inApoe−/−Mice

(2010) Graeme A. Deuchar et al.   ENDOCRINOLOGY

The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure

(2010) Aurelie Nguyen Dinh Cat et al.   FASEB JOURNAL

Placental growth factor mediates aldosterone-dependent vascular injury in mice

(2010) Iris Z. Jaffe et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice

(2010) Michael G. Usher et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloid-Specific Deletion of the Mineralocorticoid Receptor Reduces Infarct Volume and Alters Inflammation During Cerebral Ischemia

(2010) Ryan A. Frieler et al.   STROKE

Deletion of Mineralocorticoid Receptors From Macrophages Protects Against Deoxycorticosterone/Salt-Induced Cardiac Fibrosis and Increased Blood Pressure

(2009) Amanda J. Rickard et al.   HYPERTENSION

Aldosterone Increases Oxidant Stress to Impair Guanylyl Cyclase Activity by Cysteinyl Thiol Oxidation in Vascular Smooth Muscle Cells

(2009) Bradley A. Maron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Mineralocorticoid Receptors in Human Vascular Endothelial Cells Regulate Intercellular Adhesion Molecule-1 Expression and Promote Leukocyte Adhesion

(2008) Massimiliano Caprio et al.   CIRCULATION RESEARCH

The Role of Mineralocorticoid Receptor Expression in Brain Remodeling after Cerebral Ischemia

(2008) Naofumi Oyamada et al.   ENDOCRINOLOGY

Spironolactone suppresses inflammation and prevents L-NAME–induced renal injury in rats

(2008) Hirofumi Ikeda et al.   KIDNEY INTERNATIONAL

Aldosterone Induces Superoxide Generation via Rac1 Activation in Endothelial Cells

(2007) Fumiko Iwashima et al.   ENDOCRINOLOGY