Diet-Induced Obesity Promotes Kidney Endothelial Stiffening and Fibrosis Dependent on the Endothelial Mineralocorticoid Receptor

Targeting renal fibrosis: Mechanisms and drug delivery systems

(2018) Madalina V. Nastase et al.   ADVANCED DRUG DELIVERY REVIEWS

Cellular mechanisms underlying obesity-induced arterial stiffness

(2018) Annayya R. Aroor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mechanisms of Renal Fibrosis

(2018) Benjamin D. Humphreys   Annual Review of Physiology

Association of Pulse Wave Velocity With Chronic Kidney Disease Progression and MortalityNovelty and Significance

(2018) Raymond R. Townsend et al.   HYPERTENSION

Cellular and molecular mechanisms of kidney fibrosis

(2018) Sonja Djudjaj et al.   MOLECULAR ASPECTS OF MEDICINE

Endothelial mineralocorticoid receptor ablation does not alter blood pressure, kidney function or renal vessel contractility

(2018) Sidsel B. Laursen et al.   PLoS One

The Role of Dendritic and Endothelial Cells in Cardiorenal Syndrome

(2018) Grazia Maria Virzì et al.   CardioRenal Medicine

Sex‐Specific Mechanisms of Resistance Vessel Endothelial Dysfunction Induced by Cardiometabolic Risk Factors

(2018) Ana P. Davel et al.   Journal of the American Heart Association

Mechanisms and Subclinical Consequences of Aortic Stiffness

(2017) Gary L. Pierce   HYPERTENSION

Obesity and kidney disease: from population to basic science and the search for new therapeutic targets

(2017) Adam Whaley-Connell et al.   KIDNEY INTERNATIONAL

The third path of tubulointerstitial fibrosis: aberrant endothelial secretome

(2017) Mark Lipphardt et al.   KIDNEY INTERNATIONAL

Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update

(2017) Hua Su et al.   Frontiers in Immunology

Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in FemalesNovelty and Significance

(2016) Guanghong Jia et al.   CIRCULATION RESEARCH

Regular Exercise Reduces Endothelial Cortical Stiffness in Western Diet–Fed Female MiceNovelty and Significance

(2016) Jaume Padilla et al.   HYPERTENSION

Trends in Obesity Prevalence Among Children and Adolescents in the United States, 1988-1994 Through 2013-2014

(2016) Cynthia L. Ogden et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sex Differences in Associations Among Obesity, Metabolic Abnormalities, and Chronic Kidney Disease in Japanese Men and Women

(2016) Masaru Sakurai et al.   JOURNAL OF EPIDEMIOLOGY

Endostatin and transglutaminase 2 are involved in fibrosis of the aging kidney

(2016) Chi Hua Sarah Lin et al.   KIDNEY INTERNATIONAL

The Central Role of Endothelial Dysfunction in Cardiorenal Syndrome

(2016) Jun Zhang et al.   CardioRenal Medicine

Arterial Stiffening in Western Diet-Fed Mice Is Associated with Increased Vascular Elastin, Transforming Growth Factor-β, and Plasma Neuraminidase

(2016) Christopher A. Foote et al.   Frontiers in Physiology

Arterial Stiffness: A Novel Cardiovascular Risk Factor in Kidney Disease Patients

(2015) Panagiotis Georgianos et al.   Current Vascular Pharmacology

M2 Macrophage Polarization Mediates Anti-inflammatory Effects of Endothelial Nitric Oxide Signaling

(2015) Woo Je Lee et al.   DIABETES

Endothelial Mineralocorticoid Receptor Deletion Prevents Diet-Induced Cardiac Diastolic Dysfunction in Females

(2015) Guanghong Jia et al.   HYPERTENSION

Endothelial Mineralocorticoid Receptors Differentially Contribute to Coronary and Mesenteric Vascular Function Without Modulating Blood PressureNovelty and Significance

(2015) Katelee Barrett Mueller et al.   HYPERTENSION

Low-Dose Mineralocorticoid Receptor Blockade Prevents Western Diet–Induced Arterial Stiffening in Female MiceNovelty and Significance

(2015) Vincent G. DeMarco et al.   HYPERTENSION

Mediation Analysis of Aortic Stiffness and Renal Microvascular Function

(2014) T. Woodard et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Myeloid Mineralocorticoid Receptor Activation Contributes to Progressive Kidney Disease

(2014) L. L. Huang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The obligatory role of the actin cytoskeleton on inward remodeling induced by dithiothreitol activation of endogenous transglutaminase in isolated arterioles

(2013) Jorge A. Castorena-Gonzalez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Obesity and Insulin Resistance Induce Early Development of Diastolic Dysfunction in Young Female Mice Fed a Western Diet

(2013) Camila Manrique et al.   ENDOCRINOLOGY

Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity

(2013) Nicola Schäfer et al.   EUROPEAN HEART JOURNAL

Renal cell neoplasias: reversion-inducing cysteine-rich protein with Kazal motifs discriminates tumor subtypes, while extracellular matrix metalloproteinase inducer indicates prognosis

(2013) Anja Rabien et al.   Journal of Translational Medicine

Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage

(2013) Thian Kui Tan et al.   LABORATORY INVESTIGATION

Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis

(2013) Nancy J. Brown   Nature Reviews Nephrology

C-Peptide Prevents Hyperglycemia-Induced Endothelial Apoptosis Through Inhibition of Reactive Oxygen Species–Mediated Transglutaminase 2 Activation

(2012) Mahendra Prasad Bhatt et al.   DIABETES

Nitric oxide regulates tissue transglutaminase localization and function in the vasculature

(2011) Simran K. Jandu et al.   AMINO ACIDS

The Redox State of Transglutaminase 2 Controls Arterial Remodeling

(2011) Jeroen van den Akker et al.   PLoS One

Functional consequences of the collagen/elastin switch in vascular remodeling in hyperhomocysteinemic wild-type, eNOS−/−, and iNOS−/− mice

(2010) Mesia M. Steed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice

(2010) Michael G. Usher et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue Transglutaminase Contributes to Interstitial Renal Fibrosis by Favoring Accumulation of Fibrillar Collagen through TGF-β Activation and Cell Infiltration

(2008) Nasim Shweke et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage

(2008) Gary F. Mitchell   JOURNAL OF APPLIED PHYSIOLOGY

Association between obesity and kidney disease: A systematic review and meta-analysis

(2007) Y. Wang et al.   KIDNEY INTERNATIONAL